The present study aimed to investigate whether the response variability of infants to modified constraint-induced movement therapy and bimanual therapy are associated with different types of brain lesions.
Method:
Infants with unilateral cerebral palsy (N = 22) ages 8-15 months (mean = 10.95, standard deviation = 2.15 months) were grouped according to having either a periventricular brain lesion or a middle cerebral artery infarct lesion. Improvement in hand function was analyzed based on the mini–Assistive Hand Assessment results.
Results:
Infants with periventricular brain lesion displayed greater positive response to upper limb treatment compared to those with middle cerebral artery infarct (P = .02). A significant difference in improvement according to type of treatment was found in the middle cerebral artery infarct group but not in the periventricular brain lesion.
Conclusion:
The present study showed an association between the type of brain lesion and the efficacy of upper limb treatment in infants. Infants with periventricular brain lesions displayed greater positive responses than those with middle cerebral artery infarct.
RosenbaumPPanethNLevitonA. A report: the definition and classification of cerebral palsy April 2006. Dev Med Child Neurol. 2007;49:8–14.
2.
AshwalSRussmanBSBlascoPA. Practice parameter: diagnostic assessment of the child with cerebral palsy: report of the Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society. Neurology. 2004;62:851–863.
BrownMGordonWA. Impact of impairment on activity patterns of children. Arch Phys Med Rehabil. 1987;68(12):828–832.
5.
EliassonACForssbergHIkutaK. Development of human precision grip. Exp Brain Res. 1995;106:425–433.
6.
SteenbergenBVerrelJGordonAM. Motor planning in congenital hemiplegia. Disabil Rehabil. 2007;29(1):13–23.
7.
SteenbergenBGordonAM. Activity limitation in hemiplegic cerebral palsy: Evidence for disorder in motor planning. Dev Med Child Neurol. 2006;48:780–783.
8.
MaegakiYMaeokaYIshiiS. Mechanisms of central motor reorganization in pediatric hemiplegic patients. Neuropediatrics. 1997;28(3):168–174.
9.
HolmefurMKrumlinde-SundholmLBergstromJEliassonA. Longitudinal development of hand function in children with unilateral cerebral palsy. Dev Med Child Neurol. 2009;52:413–421.
10.
InguaggiatoESgandurraGPerazzaS. Brain reorganization following intervention in children with congenital hemiplegia: a systematic review. Neural Plast. 2013;2013:356275.
11.
EyreJASmithMDabydeenL. Is hemiplegic cerebral palsy equivalent to amblyopia of the corticospinal system?Ann Neurol. 2007;62(5):493–503.
12.
Krägeloh-MannI. Imaging of early brain injury and cortical plasticity. Exp Neurol. 2004;190(1):84–90.
13.
van der AaNEVerhageCHGroenendaalF. Neonatal neuroimaging predicts recruitment of contralesional corticospinal tracts following perinatal brain injury. Dev Med Child Neurol. 2013;55(8):707–712.
14.
CioniGSalesBPaolicelliPB. MRI and clinical characteristics of children with hemiplegic cerebral palsy. Neuropediatrics. 1999;30(05):249–255.
15.
FeysHEyssenMJaspersE. Relation between neuroradiological findings and upper limb function in hemiplegic cerebral palsy. Eur J Paediatr Neurol. 2010;14(2):169–177.
16.
HolmefurMKitsABergströmJ. Neuroradiology can predict the development of hand function in children with unilateral cerebral palsy. Neurorehabil Neural Repair. 2013;27(1):72–78.
17.
StaudtMGerloffCGroddW. Reorganization in congenital hemiparesis acquired at different gestational ages. Ann Neurol. 2004;56(6):854–863.
18.
JaspersEByblowWDFeysHWenderothN. The corticospinal tract: a biomarker to categorize upper limb functional potential in unilateral cerebral palsy. Front Pediatr. 2016;3:112.
19.
CarrLJHarrisonLMEvansALStephensJA. Patterns of central motor reorganization in hemiplegic cerebral palsy. Brain. 1993;116(5):1223–1247.
20.
HolmströmLVollmerBTedroffK. Hand function in relation to brain lesions and corticomotor-projection pattern in children with unilateral cerebral palsy. Dev Med Child Neurol. 2009;52(2):145–152.
21.
ChenYPPopeSTylerDWarrenGL. Effectiveness of constraint-induced movement therapy on upper-extremity function in children with cerebral palsy: a systematic review and meta-analysis of randomized controlled trials. Clin Rehabil. 2014;28(10):939–953.
22.
ChiuHCAdaL. Constraint-induced movement therapy improves upper limb activity and participation in hemiplegic cerebral palsy: a systematic review. J Physiother. 2016;62(3):130–137.
23.
ChenHCKangLJChenCL. Younger children with cerebral palsy respond better than older ones to therapist-based constraint-induced therapy at home on functional outcomes and motor control. Phys Occup Ther Pediatr. 2016;36(2):171–185.
24.
EliassonACKrumlinde-SundholmLShawKWangC. Effects of constraint-induced movement therapy in young children with hemiplegic cerebral palsy: an adapted model. Dev Med Child Neurol. 2005;47:266–275.
25.
GordonAMCharlesJWolfSL. Efficacy of constraint-induced movement therapy on involved upper-extremity use in children with hemiplegic cerebral palsy is not age-dependent. Pediatrics. 2006;117(3):e363–e373.
26.
SakzewskiLZivianiJBoydRN. Best responders after intensive upper-limb training for children with unilateral cerebral palsy?Arch Phys Med Rehabil. 2011;92(4):578–584.
27.
KuhnkeNJuengerHWaltherM. Do patients with congenital hemiparesis and ipsilateral corticospinal projections respond differently to constraint-induced movement therapy?Dev Med Child Neurol. 2008;50(12):898–903.
28.
JuengerHKuhnkeNBraunC. Two types of exercise-induced neuroplasticity in congenital hemiparesis: a transcranial magnetic stimulation, functional MRI, and magnetoencephalography study. Dev Med Child Neurol. 2013;55(10):941–951.
29.
RoccaMATurconiACStrazzerS. MRI predicts efficacy of constraint-induced movement therapy in children with brain injury. Neurotherapeutics. 2013;10(3):511–519.
30.
StaudtMBerweckS. Is constraint-induced movement therapy harmful in unilateral spastic cerebral palsy with ipsilateral cortico-spinal projections?Dev Med Child Neurol. 2014;56(3):202–203.
31.
ChamudotRParushSRigbiA. Effectiveness of modified-constraint induced movement therapy compared to bimanual therapy home programs for infants with hemiplegia: a randomized controlled trial. Am J Occup Ther. 72 (6).
32.
CokerPLebkicherCHarrisLSnapeJ. The effects of constraint-induced movement therapy for a child less than one year of age. NeuroRehabilitation. 2009;24(3):199–208.
33.
CopeSMForstHCBibisDLiuXC. Modified constraint-induced movement therapy for a 12-month-old child with hemiplegia: a case report. Am J Occup Ther. 2008;62(4):430–437.
34.
DeLucaSCEcholsKRameySLTaubE. Pediatric constraint-induced movement therapy for a young child with cerebral palsy: two episodes of care. Phys Ther. 2003;83(11):1003–1013.
35.
FergusABucklerJFarrellJ. Constraint-induced movement therapy for a child with hemiparesis: a case report. Pediatr Phys Ther. 2008;20(3):271–283.
36.
LowesLPMayhanMOrrT. Pilot study of the efficacy of constraint-induced movement therapy for infants and toddlers with cerebral palsy. Phys Occup Ther Pediatr. 2014;34(1):4–21.
37.
GreavesSKrumlinde-SundholmL. Mini–Assisting Hand Assessment (AHA), English version: 1. Melbourne/Stockholm; 2013.
38.
GreavesSImmsCDoddKKrumlinde-SundholmL. Development of the mini-Assisting Hand Assessment: evidence for content and internal scale validity. Dev Med Child Neurol. 2013;5(11):1030–1037.
39.
EliassonACKrumlinde-SundholmLGordonAM. Guidelines for future research in constraint-induced movement therapy for children with unilateral cerebral palsy: an expert consensus. Dev Med Child Neurol. 2014;56(2):125–137.
40.
IslamMNordstrandLHolmstromL. Is outcome of constraint-induced movement therapy in unilateral cerebral palsy dependent on corticomotor projection pattern and brain lesion characteristics?Dev Med Child Neurol. 2014;56(3):252–258.
41.
HoltRLMikatiMA. Care for child development: basic science rationale and effects of interventions. Pediatr Neurol. 2011;44(4):239–253.
42.
FrielKMWilliamsPTSerradjN. Activity-based therapies for repair of the corticospinal system injured during development. Front Neurol. 2014;5:229.
43.
SutcliffeTLGaetzWCLoganWJ. Cortical reorganization after modified constraint-induced movement therapy in pediatric hemiplegic cerebral palsy. J Pediatr Neurol. 2007;22(11):1281–1287.
44.
FrielKMKuoHCCarmelJB. Improvements in hand function after intensive bimanual training are not associated with corticospinal tract dysgenesis in children with unilateral cerebral palsy. Exp Brain Res. 2014;232(6):2001–2009.
45.
Soltirovska SalamonAGroenendaalFHaastertIC. Neuroimaging and neurodevelopmental outcome of preterm infants with a periventricular haemorrhagic infarction located in the temporal or frontal lobe. Dev Med Child Neurol. 2014;56(6):547–555.
