Is Cerebral Palsy Changing in High Resource Settings? Data From the Quebec Cerebral Palsy Registry

Abstract

Advances in maternal and perinatal care in developed countries have led to improved health outcomes for children. These changes may have impacted the profile of children with a cerebral palsy (CP) and groups at risk for CP over time. Using data from the Canadian CP Registry, the objectives of this retrospective cohort study were to describe the profile of children with CP in Quebec born between 1999 and 2010 and identify possible temporal variation in CP risk factors and phenotypic profile. Our sample consisted of 662 children with CP in Quebec. No change in profile or associated risk factors was observed across the birth cohorts 1999 to 2010. Prematurity remains the largest risk factor for CP in Quebec, and children with CP have multiple comorbidities that contribute to overall CP burden. CP registries offer a unique platform to study spectrum disorders and their longitudinal changes over time.

Keywords

cerebral palsy pediatric risk factors developmental disability outcome

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References

McIntyre

Taitz

Keogh

Goldsmith

Badawi

Blair

. A systematic review of risk factors for cerebral palsy in children born at term in developed countries. Dev Med Child Neurol. 2013;55(6):499–508.

Shah

McDonald

Barrett

et al. The Canadian Preterm Birth Network: a study protocol for improving outcomes for preterm infants and their families. CMAJ Open. 2018;6(1):E44–E49.

Gunby

Bissonnette

Librach

Cowan

. Assisted reproductive technologies (ART) in Canada: 2006 results from the Canadian ART Register. Fertil Steril. 2010;93(7):2189–2201.

Briana

Malamitsi-Puchner

. Twins and neurodevelopmental outcomes: the effect of IVF, fetal growth restriction, and preterm birth. J Matern Fetal Neonatal Med. 2019;32:2256–2261.

Reid

Meehan

McIntyre

Goldsmith

Badawi

Reddihough

. Temporal trends in cerebral palsy by impairment severity and birth gestation. Dev Med Child Neurol. 2016;58(suppl 2):25–35.

Rosenbaum

Paneth

Leviton

et al. A report: the definition and classification of cerebral palsy April 2006. Dev Med Child Neurol Suppl. 2007;109:8–14.

Garfinkle

Wintermark

Shevell

Platt

Oskoui

; Canadian Cerebral Palsy Register. Cerebral palsy after neonatal encephalopathy: how much is preventable? J Pediatr. 2015;167(1):58–63.e51.

Smilga

Garfinkle

et al. Neonatal infection in children with cerebral palsy: a registry-based cohort study. Pediatr Neurol. 2018;80:77–83.

Schneider

Zhang

et al. The association between maternal age and cerebral palsy risk factors. Pediatr Neurol. 2018;82:25–28.

10.

Institut de la statistique du Quebec. Le bilan demographique du Quebec. Quebec2017.

11.

Statistics Canada. 2016 Census of the Population, Statistics Canada Catalogue no. 98-400-X2016189. 2016.

12.

Hayley

S-S

Sarah

Catherine

et al. A special supplement: findings from the Australian Cerebral Palsy Register, birth years 1993 to 2006. Dev Med Child Neurol. 2016;58(suppl 2):5–10.

13.

Meehan

Freed

Reid

et al. Tertiary paediatric hospital admissions in children and young people with cerebral palsy. Child Care Health Dev. 2015;41(6):928–937.

14.

Buonocore

Perrone

Turrisi

Kramer

Balduini

. New pharmacological approaches in infants with hypoxic-ischemic encephalopathy. Curr Pharm Des. 2012;18(21):3086–3100.