Chitosan gel beads were prepared as a model for new chitosan materials and their blood compatibility was evaluated in vitroin human pool plasma and in human whole blood. The one-stage method for the preparation of monolithic beads consisted of performing a template polymerization of 2-acryloylamido-2-methylpropanesulfonic acid (AMPS) or copolymerization of AMPS and acrylic acid. Monolithic beads of semi-interpenetrating networks chitosan/copolymer were prepared in the presence of a cross-linking agent. The equilibrium degree of swelling of the beads was dependent on the composition. Reservoir-type beads consisting of a chitosan core and a coating of polyelectrolyte complex with anticoagulant activity and chitosan were also prepared. The reservoir-type beads and the monolithic beads showed improved compatibility with blood in comparison with the uncoated chitosan beads.
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