Surface functionalization of polypropylene devices with hemocompatible DMAAm and NIPAAm grafts for norfloxacin sustained release

Abstract

To improve the hemocompatibility and elution of antimicrobial agents for medical devices, N,N′-dimethylacrylamide (DMAAm) and N-isopropylacrylamide (NIPAAm) were sequentially grafted onto polypropylene (PP) films. Various (PP-g-DMAAm)-g-NIPAAm grafts were prepared using different time periods of irradiation while keeping the radiation dose constant. The hydrogel layer that formed on the surface of the PP was temperature-responsive (shifted from 32°C for NIPAAm to 37°C for the copolymer). The (PP-g-DMAAm)-g-NIPAAm films adsorbed serum albumin but not fibrinogen and had significantly lower hemolytic and thrombogenic activity. The DMAAm promoted the loading of norfloxacin (13.3 μg cm^—2) when the hydrogel layer was swollen; as the NIPAAm shrank, a sustained delivery (∼6 h) occurred at body temperature. These functionalized PP films have potential as hemo- and cyto-compatible materials for medical devices and drug delivery products.

Keywords

N N′-dimethylacrylamide N-isopropylacrylamide polypropylene films γ-ray irradiation polymer grafted surfaces drug-eluting drug delivery norfloxacin medical device hemolysis thrombogenicity

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