Physicochemical,molecular,and biological properties of complexes formed between aminoglycoside antibiotics and some anionic copolymers of acrylic series: Part II
Restricted accessResearch articleFirst published online November, 2015
Physicochemical,molecular,and biological properties of complexes formed between aminoglycoside antibiotics and some anionic copolymers of acrylic series: Part II
Physicochemical and molecular properties of complexes formed by aminoglycoside antibiotics, including neomycin, gentamicin, kanamycin, and amikacin, in the form of bases and carboxyl- or sulfo-comprising copolymers of acrylamide or N-(2-hydroxypropyl)methacrylamide have been studied. The toxicity of complexes in vitro and their antimicrobial activity are matched to their behavior in solutions. Direct dependency of toxic and antibacterial properties of polymer complexes of aminoglycoside antibiotics on their molecular characteristics and stability opens up perspectives of targeting control over their antimicrobial activity by changing the microstructure of their polymer carrier chains.
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