The increasing demand for sustainable and eco-friendly solutions in the medical industry has driven the exploration of new materials and technologies. Waste-based textile biosensors hold significant promise due to their biocompatibility, low immunogenicity, and potential for disease monitoring and diagnostics. This article discusses the characteristics and utilization of three biopolymers: silk, cellulose, and chitosan. These polymers have unique structures that make them appropriate for applications as natural, lightweight, low-density polymers with advantageous chemical and easily degradable properties. The incorporation of biosensors, particularly those integrated into textiles, has become integral for non-invasive medical monitoring. Recent advances in biopolymer-based sensors are highlighted, underscoring their potential for continuous health monitoring and personalized healthcare. The inherent advantages of these sustainable materials, combined with their sensing capabilities, position biopolymer textile waste-based biosensors as a promising solution for wearable and implantable biomedical devices.
PandeyRMathurG.Biopolymer-based biosensors: fabrication and properties. In: KrupanidhiSBSharmaASinghA, et al. (eds) Recent advances in functional materials and devices. Singapore: Springer, 2024, pp.1–10, 3 Vol. 37.
2.
JummaatFYahyaEBKhalilHPSA, et al. The role of biopolymer-based materials in obstetrics and gynecology applications: a review. Polymers2021; 13(4): 633.
3.
NathNChakrobortySVishwakarmaDP, et al. Recent advances in sustainable nature-based functional materials for biomedical sensor technologies. Environ Sci Pollut Res2023; 1–25.
4.
HolzingerMBuzzettiPHMCosnierS.Polymers and nano-objects, a rational combination for developing health monitoring biosensors. Sens Actuators B Chem2021; 348: 130700.
5.
RajkumarRRajamJAKarpagavinayagamP, et al. Future sustainability and sensitivity of nanostructured material–based electrochemical biosensors over other technologies. In: Jamballi GM (ed.) Novel nanostructured materials for electrochemical bio-sensing applications. Amsterdam, Netherland: Elsevier Publisher, 2023, pp.575–595.
6.
BeheraAMahapatraSRMajhiS, et al. Gold nanoparticle assisted colorimetric biosensors for rapid polyethylene terephthalate (PET) sensing for sustainable environment to monitor microplastics. Environ Res2023; 234: 116556.
7.
KummariSPanickerLRRao BommiJ, et al. Trends in paper-based sensing devices for clinical and environmental monitoring. Biosensors2023; 13(4): 420.
8.
DeyasiABasakASarkarA. Application of nanomaterial-based biosensors for healthcare diagnostic. In: Dutta G and Biswas A (eds) Next generation smart nano-bio-devices, smart innovation, systems and technologies. Singapore: Springer, 2022, Vol. 322, pp.103–122.
9.
KamitaGFrka-PetesicBAllardA, et al. Biocompatible and sustainable optical strain sensors for large-area applications. Adv Opt Mater2016; 4(12): 1950–1954.
10.
LiXDingCLiX, et al. Electronic biopolymers: from molecular engineering to functional devices. Chem Eng J2020; 397: 1–17.
11.
LingSChenWFanY, et al. Biopolymer nanofibrils: structure, modeling, preparation, and applications. Prog Polym Sci2018; 85: 1–56.
12.
OmenettoFGKaplanDL.New opportunities for an ancient material. Science2010; 329(5991): 528–531.
13.
NiuQHuangXLvS, et al. Natural polymer-based bioabsorbable conducting wires for implantable bioelectronic devices. J Mater Chem A2020; 8(47): 25323–25335.
14.
YangHFanFRXiY, et al. Bio-Derived natural materials based triboelectric devices for Self-Powered ubiquitous wearable and implantable intelligent devices. Adv Sustain Syst2020; 4(9): 1–22.
15.
TuwalskaAGrabska-ZielińskaSSionkowskaA. Chitosan/silk fibroin materials for biomedical applications—a review. Polymers2022; 14(7).
16.
WangCXiaKWangH, et al. Advanced carbon for flexible and wearable electronics. Adv Mater2019; 31(9): 1–37.
17.
WangCXiaKZhangY, et al. Recent progress in silk fibroin-based flexible electronics. Account Chem Res2019; 52(10): 2916.
18.
ChakravartySGogoiBMandalBB, et al. Silk fibroin as a platform for dual sensing of vitamin B12 using photoluminescence and electrical techniques. Biosens Bioelectron2018; 112: 18–22.
19.
YangNQiPRenJ, et al. Polyvinyl alcohol/silk fibroin/borax hydrogel ionotronics: a highly stretchable, self-healable, and biocompatible sensing platform. ACS Appl Mater Interfaces2019; 11(26): 23632–23638.
20.
KhalidAPengLArmanA, et al. Silk: a bio-derived coating for optical fiber sensing applications. Sens Actuators B Chem2020; 311: 1.
21.
SongYHuCWangZ, et al. Silk-based wearable devices for health monitoring and medical treatment. IScience2024; 27(5): 109604.
22.
KadumudiFBHasanyMPierchalaMK, et al. The manufacture of unbreakable bionics via multifunctional and self-healing silk-graphene hydrogels. Adv Mater2021; 33(35): 1–14.
23.
HeFYouXGongH, et al. Stretchable, biocompatible, and multifunctional silk fibroin-based hydrogels toward wearable strain/pressure sensors and triboelectric nanogenerators. ACS Appl Mater Interfaces2020; 12(5): 6442–6450.
24.
LiuXLiuJWangJ, et al. Bioinspired, microstructured silk fibroin adhesives for flexible skin sensors. ACS Appl Mater Interfaces2020; 12(5): 5601–5609.
25.
RahighiRPanahiMAkhavanO, et al. Pressure-engineered electrophoretic deposition for gentamicin loading within osteoblast-specific cellulose nanofiber scaffolds. Mater Chem Phys2021; 272: 125018.
26.
KalkaSHuberTSteinbergJ, et al. Biodegradability of all-cellulose composite laminates. Compos Part A Appl Sci Manuf2014; 59: 37–44.
27.
NechyporchukOYuJNierstraszVA, et al. Cellulose nanofibril-based coatings of woven cotton fabrics for improved inkjet printing with a potential in e-textile manufacturing. ACS Sustain Chem Eng2017; 5(6): 4793–4801.
28.
ZhengQCaiZMaZ, et al. Cellulose nanofibril/reduced graphene oxide/carbon nanotube hybrid aerogels for highly flexible and all-solid-state supercapacitors. ACS Appl Mater Interfaces2015; 7(5): 3263–3271.
29.
WangZCarlssonDOTammelaP, et al. Surface modified nanocellulose fibers yield conducting polymer-based flexible supercapacitors with enhanced capacitances. ACS Nano2015; 9(7): 7563–7571.
30.
ZhuBWangHLeowWR, et al. Silk fibroin for flexible electronic devices. Adv Mater2016; 28(22): 4250–4265.
31.
ZhangTYangLYanX, et al. Recent advances of cellulose-based materials and their promising application in sodium-ion batteries and capacitors. Small2018; 14(47): 1–20.
32.
DuttaSKimJIdeY, et al. 3D network of cellulose-based energy storage devices and related emerging applications. Mater Horiz2017; 4(4): 522–545.
33.
NeubauerovaKCarneiroMCCGRodriguesLR, et al. Nanocellulose- based biosensor for colorimetric detection of glucose. Sens Biosensing Res2020; 29: 100368.
34.
WangMLiRFengX, et al. Cellulose nanofiber-reinforced ionic conductors for multifunctional sensors and devices. ACS Appl Mater Interfaces2020; 12(24): 27545–27554.
35.
ChenZHuYZhuoH, et al. Compressible, elastic, and pressure-sensitive carbon aerogels derived from 2D titanium carbide nanosheets and bacterial cellulose for wearable sensors. Chem Mater2019; 31(9): 3301–3312.
36.
KistlerSS.Coherent expanded Aerogels and Jellies. Nature1931; 127(3211): 741–741.
37.
KhalilHPSAdnanASYahyaEB, et al. A review on plant cellulose nanofibre-based aerogels for biomedical applications. Polymers2020; 12(8): 1759.
38.
WengLBodaSKWangH, et al. Novel 3D Hybrid nanofiber aerogels coupled with BMP-2 peptides for cranial bone regeneration. Adv Healthc Mater2018; 7(10): 1–16.
39.
SalgadoMSantosFRodríguez-RojoS, et al. Development of barley and yeast β-glucan aerogels for drug delivery by supercritical fluids. J CO2 Util2017; 22: 262–269.
40.
EdwardsJVFontenotKRPrevostNT, et al. Protease biosensors based on peptide-nanocellulose conjugates: from molecular design to dressing interface. Int J Med Res2016; 3(1): 018.
41.
WeishauptRSiqueiraGSchubertM, et al. A protein-nanocellulose paper for sensing copper ions at the nano- to micromolar level. Adv Funct Mater2017; 27(4): 1–10.
BonarddSMoralesNGenceL, et al. Doped poly(3-hexylthiophene) coatings onto chitosan: a novel approach for developing a bio-based flexible electronic. ACS Appl Mater Interfaces2020; 12(11): 13275–13286.
44.
TongRChenGPanD, et al. Highly stretchable and compressible cellulose ionic hydrogels for flexible strain sensors. Biomacromolecules2019; 20(5): 2096–2104.
45.
WangLWangDWangK, et al. Biocompatible mxene/chitosan-based flexible bimodal devices for real-time pulse and respiratory rate monitoring. Mater Lett2021; 3(7): 921–929.
46.
HosseiniESManjakkalLShakthivelD, et al. Glycine–chitosan-based flexible biodegradable piezoelectric pressure sensor. ACS Appl Mater Interfaces2020; 12(8): 9008–9016.
47.
HroncekovaSBertokTHiresM, et al. Ultrasensitive Ti3C2TX MXene/chitosan nanocomposite-based amperometric biosensor for detection of potential prostate cancer marker in urine samples. Processes2020; 8(5): 580.
48.
JangJKangKRaeis-HosseiniN, et al. Self-powered humidity sensor using chitosan-based plasmonic metal–hydrogel–metal filters. Adv Opt Mater2020; 8: 1901932.
49.
WuSWuSZhangX, et al. Chitosan-based hydrogels for bioelectronic sensing: recent advances and applications in biomedicine and food safety. Biosensors2023; 13(1): 93.
50.
ShiXWuP.A smart patch with on-demand detachable adhesion for bioelectronics. Small2021; 17(26), 2101220.
PangCLiFHuX, et al. Degradable silk fibroin based piezoresistive sensor for wearable biomonitoring. Discov Nano2024; 19(1): 55.
53.
RizalSH. P. SAKOyekanmiAA, et al. Cotton wastes functionalized biomaterials from micro to nano: a cleaner approach for a sustainable environmental application. Polymers2021; 13(7): 1006.
54.
HemmatiFJafariSMTaheriRA.Optimization of homogenization-sonication technique for the production of cellulose nanocrystals from cotton linter. Int J Biol Macromol2019; 137: 374–381.
55.
RizalSLaiTKMuksinU, et al. Properties of macroalgae biopolymer films reinforcement with polysaccharide microfibre. Polymers2020; 12(11): 2554.
56.
SubbaiahMPSankaranM.Synthesis and modification strategies of chitosan and its interaction with metal ions. In: JayakumarRPrabaharanM (eds) Chitosan for biomaterials III. Advances in polymer science. Cham: Springer, 2021, Vol. 287, pp.75–104.
57.
AmirthalingamSRangasamyJ.Chitosan-based biosensor fabrication and biosensing applications. In: JayakumarRPrabaharanM (eds) Chitosan for biomaterials III. Advances in polymer science. Cham: Springer, 2021, Vol. 287, pp.203–232.
58.
RamphulHGimiéFAndriesJ, et al. Sugar-cane bagasse cellulose-based scaffolds promote multi-cellular interactions, angiogenesis and reduce inflammation for skin tissue regeneration. Int J Biol Macromol2020; 157: 296–310.
59.
VartiainenJPöhlerTSirolaK, et al. Health and environmental safety aspects of friction grinding and spray drying of microfibrillated cellulose. Cellulose2011; 18(3): 775–786.
60.
PetersonDR.Biomaterials: principles and practices. Edited by WongJYBronzinoJDPetersonDR. Boca Raton, FL: CRC Press, 2012.
61.
HiorthMNilsenSThoI.Bioadhesive mini-tablets for vaginal drug delivery. Pharmaceutics2014; 6(3): 494–511.
62.
RebeloRFernandesMFangueiroR.Biopolymers in medical implants: a brief review. Procedia Eng2017; 200: 236–243.
63.
PattanashettiNAHeggannavarGBKariduraganavarMY.Smart biopolymers and their biomedical applications. Procedia Manuf2017; 12: 263–279.
64.
SionkowskaAKaczmarekBMichalskaM, et al. Preparation and characterization of collagen/chitosan/hyaluronic acid thin films for application in hair care cosmetics. Pure Appl Chem2017; 89(12): 1829–1839.
65.
YahyaEAbdulsamadMA.In-vitro antibacterial activity of carbopol-essential oils hydrogels. J Appl Sci Process Eng2020; 7(2): 564–571.
66.
CanUTuncerMNarterF, et al. Ureteral stent insertion in pregnants with intractable flank pain: a clinical experience. South Clin Istanb Eurasia2018; 29(4): 285–289.
67.
ŠkrlováKMalachováKMuñoz-BonillaA, et al. Biocompatible polymer materials with antimicrobial properties for preparation of stents. Nanomater2019; 9(11): 1548.
68.
Cazorla-LunaRNotario-PérezFMartín-IllanaA, et al. Development and in vitro/ex vivo characterization of vaginal mucoadhesive bilayer films based on ethylcellulose and biopolymers for vaginal sustained release of tenofovir. Biomacromolecules2020; 21(6): 2309–2319.
69.
Tugcu-DemirözF.Development of in situ poloxamer-chitosan hydrogels for vaginal drug delivery of benzydamine hydrochloride: textural, mucoadhesive and in vitro release properties. Marmara Pharm J2017; 21(4): 762–770.
70.
KunaMWallerJPLogueOC, et al. A biopolymer-delivered, maternally sequestered NF-κB inhibitory peptide for treatment of preeclampsia. Placenta2018; 20: 193–201.
71.
CookHDaviesKJHardingKG, et al. Defective extracellular matrix reorganization by chronic wound fibroblasts is associated with alterations in TIMP-1, TIMP-2, and MMP-2 activity. J Investig Dermatol2000; 115(2): 225–233.
72.
NormanGWestbyMJStubbsN, et al. A ‘test and treat’ strategy for elevated wound protease activity for healing in venous leg ulcers. Cochrane Database Syst Rev2016; 2016(1): CD011753.
73.
EdwardsJVFontenotKRPrevostNT, et al. Preparation, characterization and activity of a peptide-cellulosic aerogel protease sensor from Cotton. Sensors2016; 16(11): 1789.
74.
DabiriGDamstetterEPhillipsT.Choosing a wound dressing based on common wound characteristics. Adv Wound Care2016; 5(1): 32–41.
75.
TarltonJFMunroHS.Use of modified superabsorbent polymer dressings for protease modulation in improved chronic wound care. Wounds2013; 25(2): 51–57.
76.
EdwardsJVFontenotKLiebnerF, et al. Structure/function analysis of cotton-based peptide-cellulose conjugates: spatiotemporal/kinetic assessment of protease aerogels compared to nanocrystalline and paper cellulose. Int J Mol Sci2018; 19(3): 840.
77.
EdwardsJVFontenotKRLiebnerF, et al. Peptide-cellulose conjugates on cotton-based materials have protease sensor/sequestrant activity. Sensors2018; 18(7): 2334.
78.
ZhouSXieMSuJ, et al. New insights into balancing wound healing and scarless skin repair. J Tissue Eng2023; 14: 1–28. DOI: 10.1177/20417314231185848
79.
YoussefKUllahARezaiP, et al. Recent advances in biosensors for real time monitoring of pH, temperature, and oxygen in chronic wounds. Mater Today Bio2023; 22: 1–18.
80.
BandodkarAJMolinnusDMirzaO, et al. Epidermal tattoo potentiometric sodium sensors with wireless signal transduction for continuous non-invasive sweat monitoring. Biosens Bioelectron2014; 54: 603–609.
81.
BandodkarAJWangJ.Non-invasive wearable electrochemical sensors: a review. Trends Biotechnol2014; 32(7): 363–371.
82.
KhattabTADacrorySAbou-YousefH, et al. Smart microfibrillated cellulose as swab sponge-like aerogel for real-time colorimetric naked-eye sweat monitoring. Talanta2019; 211: 120166.
GlennonTO’QuigleyCMcCaulM, et al. SWEATCH’: A wearable platform for harvesting and analysing sweat sodium content. Electroanalysis2016; 28(6): 1283–1289.
85.
HoekstraRBlondeauPAndradeFJ.IonSens: a wearable potentiometric sensor patch for monitoring total ion content in Sweat. Electroanalysis2018; 30(7): 1536–1544.
86.
DolanKRouenDKimberJ.An overview of the use of urine, hair, sweat and saliva to detect drug use. Drug Alcohol Rev2004; 23(2): 213–217.
87.
KhattabTAFoudaMMGAllamAA, et al. Selective colorimetric detection of Fe (III) using metallochromic tannin-impregnated silica strips. Chem2018; 3(43): 12065–12071.
88.
GalePACaltagironeC.Fluorescent and colorimetric sensors for anionic species. Coord Chem Rev2018; 354: 2–27.
89.
ZhuHFanJWangB, et al. Fluorescent, MRI, and colorimetric chemical sensors for the first-row d-block metal ions. Chem Soc Rev2015; 44(13): 4337–4366.
90.
VilelaDGonzálezMCEscarpaA. Sensing colorimetric approaches based on gold and silver nanoparticles aggregation: chemical creativity behind the assay. A review. Anal Chim Acta2012; 751: 24–43.
91.
ZarlaidaFAdlimM.Gold and silver nanoparticles and indicator dyes as active agents in colorimetric spot and strip tests for mercury(II) ions: a review. Microchimica Acta2017; 184(1): 45–58.
92.
SaravananDVasanthiNSRamachandranT.A review on influential behaviour of biopolishing on dyeability and certain physico-mechanical properties of cotton fabrics. Carbohydr Polym2009; 76(1): 1–7.
93.
AbdelrahmanMSFoudaMMGAjaremJS, et al. Development of colorimetric cotton swab using molecular switching hydrazone probe in calcium alginate. J Mol Struct2020; 1216: 1–9.
94.
WangZSiYZhaoC, et al. Flexible and washable poly(ionic liquid) nanofibrous membrane with moisture proof pressure sensing for real-life wearable electronics. ACS Appl Mater Interfaces2019; 11(30): 27200–27209.
95.
LiYSamadYALiaoK.From cotton to wearable pressure sensor. J Mater Chem A2015; 3(5): 2181–2187.
96.
WanCChenGFuY, et al. An artificial sensory neuron with tactile perceptual learning. Adv Mater2018; 30(30): 1–7.
97.
SongYXXuWMRongMZ, et al. A sunlight self-healable fibrous flexible pressure sensor based on electrically conductive composite wool yarns. Express Polym Lett2020; 14(11): 1089–1104.
98.
ChengYWangRSunJ, et al. A stretchable and highly sensitive graphene-based fiber for sensing tensile strain, bending, and torsion. Adv Mater2015; 27(45): 7365–7371.
99.
PanLChortosAYuG, et al. An ultra-sensitive resistive pressure sensor based on hollow-sphere microstructure induced elasticity in conducting polymer film. Nat Commun2014; 5(1): 3002.
100.
BaeGYPakSWKimD, et al. Linearly and highly pressure-sensitive electronic skin based on a bioinspired hierarchical structural array. Adv Mater2016; 28(26): 5300–5306.
101.
JhaVGarcia-GarciaGIsekiK, et al. Chronic kidney disease: global dimension and perspectives. Lancet2013; 382(9888): 260–272.
102.
LeveyASEckardtK-UTsukamotoY, et al. Definition and classification of chronic kidney disease: a position statement from kidney disease: Improving Global Outcomes (KDIGO). Kidney Int2005; 67(6): 2089–2100.
103.
WebsterACNaglerEVMortonRL, et al. Chronic kidney disease. Lancet2017; 389(10075): 1238.
104.
ChaeHKSiberio-PérezDYKimJ, et al. A route to high surface area, porosity and inclusion of large molecules in crystals. Nature2004; 427(6974): 523–527.
105.
DuncanBLeNDBAlexanderC, et al. Sensing by smell: nanoparticle-enzyme sensors for rapid and sensitive detection of bacteria with olfactory output. ACS Nano2017; 11(6): 5339–5343.
106.
KhattabTAFoudaMMGAbdelrahmanMS, et al. Co-encapsulation of enzyme and tricyanofuran hydrazone into alginate microcapsules incorporated onto cotton fabric as a biosensor for colorimetric recognition of urea. React Funct Polym2019; 142: 199–206.
