In order to confirm the immuno-stimulating activity of fractionated and hydrophobized poly(maleic acid-alt-7,12-dioxaspiro-[5,61-dodec-9-ene) [poly(MA-CDA)], we evaluated exo-vivo cytokine inducing activity of the polymers using peripheral whole blood cells. The highest inducing activity of interleukin 6 (IL-6) and tumor necrosis factor-α(TNF-α) was found with the polymer with a molecular weight of ~5,000 and containing 10 mol% aniline moiety.
Get full access to this article
View all access options for this article.
References
1.
1. Rietschel E. T., L. Brade, B. Lindner and U. Zhringer. 1992. In: Bacterial Endotoxic Lipopolysaccharides. Vol. I Molecular Biochemistry and Cellular Biology. D. C. Morrison and J. L. Ryan, eds., Boca Raton, FL: CRC Press, pp. 3-41.
2.
2. Suda, Y., H. Yamamoto, M. Sumi, N. Oku, F. Ito, S. Yamashita, T. Nadai and R. M. Ottenbrite. 1992. J. Bioact. Compat. Polym., 7:15-24.
3.
3. Suda, Y., S. Kusumoto, N. Oku, H. Yamamoto, M. Sumi, F. Ito and R. M. Ottenbrite. 1992. J. Bioact. Compat. Polym., 7:275-287.
4.
4. Suda, Y., H. Tochio, K. Kawano, H. Takada, T. Yoshida, S. Kotani and S. Kusumoto. 1995. FEMS Immunology and Medical Microbiology, 12:97-112.
5.
5. Hirano, T., T. Thga, N. Nakano, K. Yasukawa, S. Kashiwamura, K. Shimizu, K. Nakajima, K. H. Pyun and T. Kishimoto. 1985. Proc. Natl. Acad. Sci. USA, 82:5490-5494.
6.
6. Ding, J.-L. and R. M. Ottenbrite. 1993. Polymer Preprints, 34(2):508-509.
