Thermal and Spectroscopic Characterization of Interactions between 2-Nonyl-1,3-Dioxolane and Stratum Corneum Components

Abstract

The effect of 2-nonyl-1,3-dioxolane (SEPA™) on the structure of human stratum corneum was investigated by FT-IR spectroscopy at variable temperature, differential scanning calorimetry and scanning electron microscopy. A significant influence of SEPA™ treatment on position and intensity of IR absorption bands and DSC thermal transitions of SC lipids was detected. An appreciable loosening of SC cell packing was also observed by SEM analysis. These modifications are reversed after SEPA™ is removed from the site of application. The results clearly demonstrate that SEPA™ is able to modify the structure of the lipid matrix in which corneocytes are embedded, thus suggesting a possible use of SEPA™ to increase the permeability of the stratum corneum to lipophilic drugs.

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References

1. Barry, B. W. Journal of Controlled Release 1991, 15, 237.

2. McKenzie, A. W. , Stougthon, R. B. Arch. Dermatol. 1962, 86, 608.

3. Stougthon, R. B. Arch. Dermatol. 1965, 91, 657.

4. Hou, S. Y. E. , Flynn, G. L. Pharm. Res. 1986, 3(suppl.), 525.

5. Friberg, S. E. , Ma, Z. N. J. Dispers. Sci. Tech. 1993, 14, 481.

6. Nolan, L. M. A. , Corish, J. , Corrigan, O. I. J. Chem. Soc. Faraday Trans. 1993, 89, 2839.

7. Dinh, S. M. , Comfort, A. R. , Shevchuk, I. , Berner, B. J. Membrane Sci. 1994, 89, 245.

8. Lin, S. Y. , Liang, R. C. , Lin, T. C. J. Chin. Chem. Soc. 1994, 41, 425.

9. Friberg, S. E. J. Dispers. Sci. Tech. 1994, 15, 359.

10.

10. Nerella, N. G. , Drennen, J. K. Appl. Spectrosc. 1996, 50, 285.

11.

11. Bezema, F. R. , Marttin, E. , Roemele, P. E. H. , Brussee, J. , Bodde, H. E. , Degroot, H. J. M. Spectrochim. Acta Pt. A-Mol. Bio. 1996, 52, 785.

12.

12. Lin, S. Y. , Duan, K. J. , Lin, T. C. Spectrochim. Acta Pt. A-Mol. Bio. 1996, 52, 1671.

13.

13. Giese, K. , Harendt, N. , Kolmel, K. Prog. Nat. Sci. 1996, 6, S581.

14.

14. Giese, K. , Harendt, N. , Kolmel, K. Prog. Nat. Sci. 1996, 6, S585.

15.

15. Iwai, H. , Fukasawa, J. , Suzuki, T. J. Colloid Interface Sci. 1997, 189, 288.

16.

16. Tanojo, H. , BosvanGeest, A. , Bouwstra, J. A. , Junginger, H. E. , Bodde, H. E. Thermochim. Acta 1997, 293, 77.

17.

17. Parra, J. L. , Coderch, L. , Yuste, I. , delaMaza, A. Colloid Surface A 1997, 123, 115.

18.

18. Bouwstra, J. A. Colloid Surface A 1997, 123, 403.

19.

19. Lopez, O. , delaMaza, A. , Coderch, L. , Parra, J. L. Colloid Surface A 1997, 123, 415.

20.

20. Ahmed, S. , Imai, T. , Otagiri, M. Enantiomer 1997, 2, 181.

21.

21. Moore, D. J. , Rerek, M. E. , Mendelsohn, R. J. Phys. Chem. B 1997, 101, 8933.

22.

22. Ongpipattanakul, B. , Burnette, R. R. , Potts, R. O. , Fracoeur, M. L. Pharm. Res. 1991, 8, 350.

23.

23. Surewicz, W. K. , Mantsch, H. H. Biochim. Biophys. Acta 1988, 952, 115.

24.

24. Krimm, S. , Bandekar, J. Adv. Protein Chem. 1986, 38, 181.

25.

25. Chirgadze, Y. N. , Fedorov, O. V. , Trushina, N. P. Biopolymers 1975, 14, 679.

26.

26. Kato, K. , Matsui, T. , Tanaka, S. Appl. Spectr. 1987, 141, 861.

27.

27. Müller, M. Biopolymers 1993, 33, 1185.

28.

28. Goodman, M. , Barry, B. W. Anal. Proc. 1986, 23, 397.

29.

29. Bouwstra, J. A. , Peschier, L. J. C. , Russe J. , Bodde, H. E. Int. J. Pharm. 1989, 52, 47.