Fatal Cardiac Dysrhythmia Following a Bupropion Overdose in an Adolescent

Bupropion is an antidepressant that is currently used in the treatment of depression, attention deficit-hyperactive disorder, and bipolar diseases; as well as an aid in smoking cessation. Although its neurotoxicity and propensity to cause seizures are well described in the literature, bupropion has been suggested to be a more desirable antidepressant when compared to the tricyclic antidepressants due to its lack of cardiotoxicity. To date, there are limited reports with regard to cardiac toxicity. The authors present a 15-year-old boy who developed torsades de pointes and cardiac arrest as a result of a bupropion overdose. Other reports of potential cardiac toxicity related to bupropion are reviewed.