Fabrication of Poly-(DL-Lactic Acid)—Wollastonite Composite Films with Surface Modified β-CaSiO 3 Particles

Abstract

Bioactive poly-(DL-lactic acid) (PDLLA)—wollastonite composite films are successfully fabricated using surface modified wollastonite (mβ-CaSiO₃) particles through solvent casting-evaporation method. The surface modification of β-CaSiO₃ particles are conducted by reaction of the ceramic particles with dodecyl alcohol. Surface morphology, tensile strength, and bioactivity of the composite films are investigated. The results show that the particle distribution and tensile strength of the composite films with modified β-CaSiO₃ particles are significantly improved while the bioactivity is retained. As a result, the maximum tensile strength is enhanced 52.2% when compared with the PDLLA—β-CaSiO₃ composite films prepared using unmodified β-CaSiO₃ particles when the inorganic filler content is 15wt%. Scanning electron microscopy (SEM) observation suggests that the modified mβ-CaSiO₃ particles are homogeneously dispersed in the PDLLA matrix. The bioactivity of the composite films is evaluated by soaking in a simulated body fluid (SBF) and the result suggests that the modified composite film is still bioactive and can induce the formation of HAp on its surface after the immersion in SBF, despite the bonded dodecyl alkyl on the surface of the inorganic particles. All these results imply that the surface modification of β-CaSiO₃ with dodecyl alcohol is an effective approach to prepare PDLLA—β-CaSiO₃ composite with improved properties.

Keywords

dodecyl alcohol wollastonite PDLLA composite film surface modification.

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References

Vaz, C.M. , Reis, R.L. and Cunha, A.M. (2002). Use of Coupling Agents to Enhance the Interfacial Interactions in Starch-EVOH/Hydroxylapatite Composites , Biomaterials, 23(2): 629—635.

Li, H. and Chang, J. (2004). Fabrication and Characterization of Bioactive Wollastonite/PHBV Composite Scaffolds , Biomaterials, 25(24): 5473—5480.

Pitt, G.G. , Gratzl, M.M. , Kimmel, G.L. , Surles, J. and Sohindler, A. (1981). Aliphatic Polyesters II. The Degradation of Poly (DL-lactide) , Poly (ε-caprolactone), and their Copolymers in vivo, Biomaterials, 2(4): 215—220.

Schliephake, H. , Neukam, F.W. , Hutmacher, D. and Becker, J. (1994). Enhancement of Bone Ingrowth into a Porous Hydroxyapatite Matrix using a Resorbable Polyactic Membrane-An Experimental Pilot-study , J. Oral Maxillofac. Surg., 52(1): 57—63.

Kikuchi, M. , Suetsugu, Y. , Tanaka, J. and Akao, M. (1997). Preparation and Mechanical Properties of Calcium Phosphate/Copoly L-lactide Composites , J. Mater. Sci. Mater. Med., 8(6): 361—364.

Shikinami, Y. and Okuno, M. (1999). Bioresorbable Devices Made of Forged Composites of Hydroxyapatite (HA) Particles and Poly L-lactide (PLLA): Part I. Basic Characteristics, Biomaterials, 20(9): 859—877.

Verrier, S. , Blaker, J.J. , Maquet, V. , Hench, L.L. and Boccaccini, A.R. (2004). PDLLA/Bioglass Composites for Soft-tissue and Hard-tissue Engineering: An in vitro Cell Biology Assessment , Biomaterials, 25(15): 3013—3021.

Hench, L.L. , Splinter, R.J. , Allen, W.C. and Greenlee, T.K. (1971). Bonding Mechanisms at the Interface of Ceramic Prosthetic Materials , J. Biomed. Mater. Res. Symp., 36(2): 117—124.

Hench, L.L. and Paschall, H.A. (1973). Direct Chemical Bond of Bioactive Glass Ceramic Materials to Bone and Muscle , J. Biomed. Mater. Res., 7(3): 25—42.

10.

Siriphannon, P. , Kameshima, Y. , Yasumori, A. , Okada, K. and Hayashi, S. (2002). Formation of Hydroxyapatite on CaSiO3 Powders in Simulated Body Fluid , J. Eur. Ceram. Soc., 22(4): 511—520.

11.

Liu, X. , Ding, C. and Wang, Z. (2001). Apatite Formed on the Surface of Plasma-sprayed Wollastonite Coating Immersed in Simulated Body Fluid , Biomaterials, 22(14): 2007—2012.

12.

Li, H. and Chang, J. (2004). Preparation and Characterization of Bioactive and Biodegradable Wollastonite/poly(D,L-lactic acid) Composite Scaffolds , J. Mater. Sci.: Mater. in Med., 15(10): 1089—1095.

13.

Sada, E. , Kumazawa, H. and Murakami, Y. (1991). Hydrothermal Synthesis of Crystalline Hydroxyapatite Ultrafine Particles , Chem. Eng. Communi., 103(1): 57—64.

14.

Fang, Y. , Agrawal, D.K. , Roy, D.M. , Roy, R. and Brown, P.W. (1992) Ultrasonically Accelerated Synthesis of Hydroxyapatite , J. Mater. Res., 7(8): 2294 .

15.

Ballard, C.C. , Broge, E.C. , John, D.S. and McWhorter , J.R. (1961). Esterification of the Surface of Amorphous Silica , J. Phys. Chem., 65(1): 20—25.

16.

Van Helden, A.K. , Jansen, J.W. and Vrij, A. (1981). Preparation and Characterization of Spherical Monodisperse Silica Dispersions in Nonaqueous Solvents , J. Colloid. Interface Sci., 81(2): 354—368.

17.

Naylor, D.L. (1992). Development of Suspensions of Rod-shaped β-FeOOH Particles in Infrared Transmitting Solvents for Use as Artificial Kerr Media , J. Mater. Res., 7(8): 2288—2293.

18.

Borum-Nicholas, L. and Wilson Jr., O.C. (2003). Surface Modification of Hydroxyapatite. Part I. Dodecyl Alcohol , Biomaterials, 24(21): 3671—3679.

19.

Cheng, W. and Chang, J. (2006). Fabrication and Characterization of Polysulfone/Dicalcium Silicate Composite Films , J. Biomater. Applic., 20(4): 361—376.

20.

Dzhigit, O.M. , Kiselev, A.V. , Mikos-Avgul, N.N. and Shcherbakova , K.D. (1950). Poisoning and Regeneration of the Surface of Silica Gel in the Adsorption of Vapors , Doklady Akademii Nauk SSSR, 70(1): 441—444.

21.

Kokubo, T. (1990). Surface Chemistry of Bioactive Glass-ceramics , J. Non-Cryst. Solids, 120(1—3): 138—151.

22.

Kolesov, B.A. and Geiger, C.A. (2006). Behavior of H2O Molecules in the Channels of Natrolite and Scolecite: A Raman and IR Spectroscopic Investigation of Hydrous Microporous Silicates , American Mineralogist, 91(7): 1039—1048.

23.

Weiss, P. , Lapkowski, M. and Legeros, R.Z. (1997). Fourier Transform Infrared Spectroscopy Study of an Organic-mineral Composite for Bone and Dental Substitute Materials , J. Mater. Sci. Mater. Med., 8(10): 621—629.

24.

Ossenkamp, G.C. , Kemmitt, T. and Johnston, J.H. (2002). Toward Functionalized Surfaces through Surface Esterification of Silica , Langmuir , 18(15): 5749—5754.

25.

Salinas, A.J. , Vallet-Regi, M. and Izquierdo-Barba , I. (2001). Biomimetic Apatite Deposition on Calcium Silicate Gel Glasses , J. Sol. Gel. Sci. Technol., 21(1—2): 13—25.

26.

Zhang, K. , Ma, Y. and Lorraine, F.F. (2002). Porous Polymer/Bioactive Glass Composites for Soft-to-Hard Tissue Interfaces , J. Biomed. Mater. Res., 61(4): 551—563.

27.

Van Wachem, P.B. , Beugeling, T. and Feijen, J. (1985). Interaction of Cultured Human Endothelial Cells with Polymeric Surfaces of Different Wettabilities , Biomaterials, 6(6): 403—408.

28.

Shioji, S. , Kawaguchi, M. , Hayashi, Y. , Tokami, K. and Yamamoto, H. (2001). Rates of Alkoxylation and Hydrolysis of Alkoxyl Groups on Silica Surfaces , Adv. Powder Technol., 12(3): 343—359.

29.

Tanahashi, M. and Matsuda, T. (1997). Surface Functional Group Dependence on Apatite Formation on Self-assembled Monolayers in a Simulated Body Fluid , J. Biomed. Mater. Res., 34(3): 305—315.

30.

Lin, K.l. , Chang, J. , Zeng, Y. and Qian, W.J. (2004). Preparation of Macroporous Calcium Silicate Ceramics , Materials Letters, 58(15): 2109—2113.