Sol–Gel Phosphate-based Glass for Drug Delivery Applications

Development of controlled, targeted drug delivery systems represents one of the frontier areas of biomaterials science, where a multidisciplinary approach is of direct benefit to human healthcare. We demonstrate herein the potential of sol–gel derived phosphate-based glass for use in drug delivery applications. Our low-temperature sol–gel synthesis of phosphate-based glasses has made it possible to incorporate relatively unstable functional molecules for controlled release. We demonstrate the potential of this approach by incorporating the chemotherapy agent cisplatin in a CaO–Na₂O–P₂O₅ glass. X-ray absorption spectroscopy is used to show that the chlorine ligands of cisplatin undergo exchange with oxygen during the synthesis, consistent with binding to the phosphate groups of the sol–gel. UV–visible spectroscopy reveals the subsequent release of cisplatin into an aqueous medium.