The aim of this study was to investigate the effect of beta-tricalcium phosphate (β-TCP) particles in combination with acellular dermal matrix (ADM) allograft in gingival recession. Experimental gingival recession defects were created in beagle dogs and randomly assigned to one of the following groups: ADM, ADM + β-TCP, or coronally positioned flap (CPF; control). Tissues were histologically examined at 4, 8, or 16 weeks following treatment. A greater thickness of gingiva was observed at the sites treated in both the ADM + β-TCP and ADM groups than in the CPF group. The ADM + β-TCP group showed a statistically significant increase in both new bone and cementum formations compared to the ADM group. The results suggest that the combination of β-TCP and ADM is more effective in promoting new bone and cementum formations than ADM graft alone.
WennströmJL. Mucogingival therapy. Ann Periodontol1996; 1(1): 671–701.
2.
CordioliGMortarinoCChiericoAGrusovinMGMajzoubZ. Comparison of 2 techniques of subepithelial connective tissue graft in the treatment of gingival recessions. J Periodontol2001; 72(11): 1470–1476.
3.
TalHMosesOZoharRMeirHNemcovskyC. Root coverage of advanced gingival recession: A comparative study between acellular dermal matrix allograft and subepithelial connective tissue grafts. J Periodontol2002; 73(12): 1405–1411.
4.
LiuCLWeisgoldAS. Connective tissue graft: A classification for incision design from the palatal site and clinical case reports. Int J Periodontics Restorative Dent2002; 22(4): 373–379.
5.
HarrisRJ. A comparative study of root coverage obtained with an acellular dermal matrix versus a connective tissue graft: Results of 107 recession defects in 50 consecutively treated patients. Int J Periodontics Restorative Dent2000; 20(1): 51–59.
6.
HendersonRDGreenwellHDriskoCRegennitterFJLambJWMehlbauerMJ. Predictable multiple site root coverage using an acellular dermal matrix allograft. J Periodontol2001; 72(5): 571–582.
7.
PaolantonioMDolciMEspositoPD'ArchivioDLisantiLDi LuccioA. Subpedicle acellular dermal matrix graft and autogenous connective tissue graft in the treatment of gingival recessions: A comparative 1-year clinical study. J Periodontol2002; 73(11): 1299–1307.
8.
EppleyBL. Experimental assessment of the revascularization of acellular human dermis for soft-tissue augmentation. Plast Reconstr Surg2001; 107(3): 757–762.
9.
WainwrightDJ. Use of an acellular allograft dermal matrix (AlloDerm) in the management of full-thickness burns. Burns1995; 21(4): 243–248.
10.
GoreDC. Utility of acellular allograft dermis in the care of elderly burn patients. J Surg Res2005; 125(1): 37–41.
11.
BatistaEL JrBatistaFCNovaesAB Jr. Management of soft tissue ridge deformities with acellular dermal matrix. Clinical approach and outcome after 6 months of treatment. J Periodontol2001; 72(2): 265–273.
12.
BarrosRRNovaesABGrisiMFSouzaSLTabaMJPaliotoDB. A 6-month comparative clinical study of a conventional and a new surgical approach for root coverage with acellular dermal matrix. J Periodontol2004; 75(10): 1350–1356.
13.
de Queiroz CôrtesASallumAWCasatiMZNocitiFH JrSallumEA. A two-year prospective study of coronally positioned flap with or without acellular dermal matrix graft. J Clin Periodontol2006; 33(9): 683–689.
14.
FelipeMEAndradePFGrisiMFSouzaSLTabaMPaliotoDB. Comparison of two surgical procedures for use of the acellular dermal matrix graft in the treatment of gingival recessions: A randomized controlled clinical study. J Periodontol2007; 78(7): 1209–1217.
15.
WeiPCLaurellLGeivelisMLingenMWMaddalozzoD. Acellular dermal matrix allografts to achieve increased attached gingiva. Part 1. A clinical study. J Periodontol2000; 71(8): 1297–1305.
16.
HarrisRJ. Clinical evaluation of 3 techniques to augment keratinized tissue without root coverage. J Periodontol2001; 72(7): 932–938.
17.
BuduneliEIlgenliTBuduneliNOzdemirF. Acellular dermal matrix allograft used to gain attached gingiva in a case of epidermolysis bullosa. J Clin Periodontol2003; 30(11): 1011–1015.
18.
CummingsLCKaldahlWBAllenEP. Histologic evaluation of autogenous connective tissue and acellular dermal matrix grafts in humans. J Periodontol2005; 76(2): 178–186.
19.
SallumEANogueira-FilhoGRCasatiMZPimentelSPSaldanhaJBNocitiFH Jr. Coronally positioned flap with or without acellular dermal matrix graft in gingival recessions: A histometric study. Am J Dent2006; 19(2): 128–132.
20.
TalH. Subgingival acellular dermal matrix allograft for the treatment of gingival recession: A case report. J Periodontol1999; 70(9): 1118–1124.
21.
RosaALBrenteganiLGGrandiniSA. Hydroxylapatite and tricalcium phosphate implants in the dental alveolus of rats. A histometric study. Braz Dent J1995; 6(2): 103–109.
22.
HossainMZKyomenSTanneK. Biologic responses of autogenous bone and beta-tricalcium phosphate ceramics transplanted into bone defects to orthodontic forces. Cleft Palate Craniofac J1996; 33(4): 277–283.
23.
OhsawaKNeoMMatsuokaHAkiyamaHItoHKohnoH. The expression of bone matrix protein mRNAs around beta-TCP particles implanted into bone. J Biomed Mater Res2000; 52(3): 460–466.
24.
PorterBDOldhamJBHeSLZobitzMEPayneRGAnKN. Mechanical properties of a biodegradable bone regeneration scaffold. J Biomech Eng2000; 122(3): 286–288.
25.
DongJUemuraTShirasakiYTateishiT. Promotion of bone formation using highly pure porous beta-TCP combined with bone marrow-derived osteoprogenitor cells. Biomaterials2002; 23(23): 4493–4502.
26.
TrisiPRaoWRebaudiAFioreP. Histologic effect of pure-phase beta-tricalcium phosphate on bone regeneration in human artificial jawbone defects. Int J Periodontics Restorative Dent2003; 23(1): 69–77.
27.
BuserDHoffmannBBernardJPLussiAMettlerDSchenkRK. Evaluation of filling materials in membrane-protected bone defects. A comparative histomorphometric study in the mandible of miniature pigs. Clin Oral Implants Res1998; 9(3): 137–150.
28.
OgoseAHottaTHatanoHKawashimaHTokunagaKEndoN. Histological examination of beta-tricalcium phosphate graft in human femur. J Biomed Mater Res2002; 63(5): 601–604.
29.
OgoseAKondoNUmezuHHottaTKawashimaHTokunagaK. Histological assessment in grafts of highly purified beta-tricalcium phosphate (OSferion) in human bones. Biomaterials2006; 27(8): 1542–1549.
30.
BowersGMChadroffBCarnevaleRMellonigJCorioREmersonJ. Histologic evaluation of new attachment apparatus formation in humans. Part III. J Periodontol1989; 60(12): 683–693.
31.
RalisZAWatkinsG. Modified tetrachrome method for osteoid and defectively mineralized bone in paraffin sections. Biotech Histochem1992; 67(6): 339–345.
32.
CasatiMZSallumEACaffesseRGNocitiFH JrSallumAWPereiraSL. Guided tissue regeneration with a bioabsorbable polylactic acid membrane in gingival recessions. A histometric study in dogs. J Periodontol2000; 71(2): 238–248.
33.
MacedoNLMatudaFSMacedoLGonzalezMBOuchiSMCarvalhoYR. Bone defect regeneration with bioactive glass implantation in rats. J Appl Oral Sci2004; 12: 137–143.
34.
VillaçaJHNovaesAB JrSouzaSLTabaM JrMolinaGOCarvalhoTL. Bioactive glass efficacy in the periodontal healing of intrabony defects in monkeys. Braz Dent J2005; 16(1): 67–74.
35.
LiveseySAHerndonDNHollyoakMAAtkinsonYHNagA. Transplanted acellular allograft dermal matrix. Potential as a template for the reconstruction of viable dermis. Transplantation1995; 60(1): 1–9.
