Mixture designs to assess composition–structure–property relationships in SiO 2 –CaO–ZnO–La 2 O 3 –TiO 2 –MgO–SrO–Na 2 O glasses: Potential materials for embolization

Embolization with micron-sized particulates is widely applied to treat uterine fibroids. The objective of this work was to develop mixture designs to predict materials composition–structure–property relationships for the SiO₂–CaO–ZnO–La₂O₃–TiO₂–MgO–SrO–Na₂O glass system and compare its fundamental materials properties (density and cytocompatibility), against a state-of-the-art embolic agent (contour polyvinyl alcohol) to assess the potential of these materials for embolization therapies. The glass structures were evaluated using ²⁹Si MAS NMR to identify chemical shift and line width; the particulate densities were determined using helium pycnometry and the cell viabilities were assessed via MTT assay. ²⁹Si MAS NMR results indicated peak maxima for each glass in the range of −82.3 ppm to −89.9 ppm; associated with Q² to Q³ units in silicate glasses. All experimental embolic compositions showed enhanced in vitro compatibility in comparison to Contour PVA with the exceptions of ORP9 and ORP11 (containing no TiO₂). In this study, optimal compositions for cell viability were obtained for the following compositional ranges: 0.095–0.188 mole fraction ZnO; 0.068–0.159 mole fraction La₂O₃; 0.545–0.562 mole fraction SiO₂ and 0.042–0.050 mole fraction TiO₂. To ensure ease of producibility in obtaining good melts, a maximum loading of 0.068 mole fraction La₂O₃ is required. This is confirmed by the desirability approach, for which the only experimental composition (ORP5) of the materials evaluated was presented as an optimum composition; combining high cell viability with ease of production (0.188 mole fraction ZnO; 0.068 mole fraction La₂O₃; 0.562 mole fraction SiO₂ and 0.042 mole fraction TiO₂).