In vitro and in vivo chemo-phototherapy of magnetic TiO 2 drug delivery system formed by pH-sensitive coordination bond

Abstract

To achieve tumor-specific delivery of doxorubicin, TiO₂@Fe₃O₄/PEI/delivery of doxorubicin conjugates were designed and synthesized. Fe₃O₄ could act as magnetically responsive carriers and enhance the visible light photodynamic activities of TiO₂. Delivery of doxorubicin was conjugated via coordination bond. The drug release rate at pH 5.2 was much faster than that at pH 7.4, due to pH-sensitive coordination bond. Besides, TiO₂@Fe₃O₄/PEI/delivery of doxorubicin showed high antitumor efficacy combining with phototherapy, good bio-safety, higher cellular uptake with an external magnetic field, and less toxicity in vitro and in vivo. These results suggested that TiO₂@Fe₃O₄/PEI/delivery of doxorubicin may be promising for high tumor treatment efficacy with minimal side effects in future.

Keywords

pH-Sensitive phototherapy tumor targeting

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