Controlled Release of Newer Quinolones from Biodegradable Systems Based on Poly(Lactic Acid)

Abstract

The release of newer quinolones (such as pefloxacin, ofloxacin, and ciprofloxacin) from biodegradable poly(DL lactic acid) has been investigated. The in vitro study showed that drug delivery takes place for about two months and a maximum in concentration was recorded after fifteen days. The release from poly(lactic acid) slabs seemed to give high drug doses that are adequate for the treatment of infections caused by common pathogens.

Keywords

controlled release biodegradable quinolones resomer oflox-acin pefloxacin ciprofloxacin

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References

1. Beck, L. R. , D. R. Cowsar, D. H. Lewis, R. J. Cosgrave, C. T. Riddle, S. L. Lowry and T. E. Epperly . 1979. Fertility and Sterility 5:545-551.

2. Genta, I. , F. Pavanetto, B. Conti and P. Giunchedi . 1991. Proceed. Intern. Control. Rel. Bioact. Mater., Controlled Release Society, Inc., 18:676-677.

3. Bottenberg, P. , C. DeMuynck, S. Bouckaert, D. Coomans, D. Slop and J. P. Remon . 1991. Proceed. Intern. Control. Ret Bioact. Mater., Controlled Release Society, Inc., 18:631-632.

4. Pitt, C. G. , M. M. Gratzl, G. L. Kimmer, J. Surles and A. Schindler . 1981. Biomaterials, 2:215-219.

5. Leenslag, J. W. , A. J. Pennings, R. R. M. Bos , F. R. Rozema and G. Boering . 1987. Biomaterials, 8:311-314.

6. Shih, C. , T. Higuchi and K. J. Himmelstein . 1984. Biomaterials, 5:237-240.

7. Bodmeier, R. , K. H. Oh and H. Chen . 1989. Internat. J. Pharm., 51:1-8.

8. Omelczuk, M. O. and J. W. McGinity . 1992. Pharm. Res., 9:26-32.

9. Wada, R. , S.-H. Hyon and Y. Ikada . 1990. J. Pharm. Sci., 79:919-924.

10.

10. Kishida, A. , J. B. Dressman, S. Yoshioka, Y. Aso and Y. Takeda . 1990. J. of Controlled Release, 13:83-89.

11.

11. Bruhn, B. W. and B. W. Muller . 1991. Proceed. Intern. Control. Rel. Bioact. Mater., Controlled Release Society, Inc., 18:668-669.

12.

12. Tice, T. R. , R. M. Gilley, D. F. Love, F. Labrie and D. W. Mason . 1991. Proceed. Intern. Control. Rel. Bioact. Mater., Controlled Release Society, Inc., 18:467-468.

13.

13. Wei, G. , Y. Kotoura, M. Oka, T. Yamamuro, R. Wada, S.-H. Hyon and J. Ikada . J. Bone Joint Surgery (Br), 73-B:246-252.

14.

14. Bodmeier, R. and H. Chen . 1989. J. Pharm. Sci., 78:819-822.

15.

15. Avgoustakis, K. and J. R. Nixon . 1991. Internat. J. Pharm., 70:77-85.

16.

16. Demirdere, A. , T. Kissel, U. Siemann and H. Sucker . 1991. Eur J. Pharm. Biopharm., 37:42-48.

17.

17. Park, T. G. , S. Cohen and R. Langer . 1992. Pharm. Res., 9:37-39.

18.

18. Dunn, R. L. , A. J. Tipton and E. M. Menardi . 1991. Controlled Release Society, Inc-, 18:465-466.

19.

19. Andreopoulos, A. G. Clinical materials, to appear.

20.

20. Zhou, Z. , M. Zhou, Z. Shen and W. Shen . 1993. Biomat, Art. Cells and Immob. Biotech., 21:475-486.