Assessing Cognition in Parkinson Disease: Use of the Cognitive Linguistic Quick Test

Abstract

Objective: To evaluate the Cognitive Linguistic Quick Test (CLQT) as a cognitive screening tool in Parkinson disease (PD). Methods: A total of 93 patients with PD were evaluated with the Mini-Mental State Examination (MMSE) and the CLQT. The CLQT provides separate ratings for 5 cognitive domains. Descriptive statistics, correlations between the tests, and diagnostic value for dementia were analyzed. Results: Cognitive Linguistic Quick Test correlated well with MMSE. Diagnostic values for dementia were similar for the 2 instruments. Unlike the MMSE, the CLQT also provided domain-specific information on cognitive deficits. Cognitive domains were differentially affected between and within the demented and nondemented patient groups with PD: memory was the weakest domain in the demented group and attention in the nondemented. Conclusions: The CLQT is a valuable instrument in assessing cognitive dysfunction in PD. The CLQT is superior to the MMSE as it also provides cognitive domain-specific information.

Keywords

Parkinson disease cognitive impairment cognitive screening dementia MMSE

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References

Brown RG , Marsden CD Cognitive function in Parkinson’s disease: from description to theory . Trends Neurosci. 1990;13(1):21-29.

Levin BE , Tomer R. , Rey GJ Cognitive impairments in Parkinson’s disease. Neurol Clin. 1992;10(2):471-485.

Bosboom JLW , Stoffers D. , Wolters EC Cognitive dysfunction and dementia in Parkinson’s disease. J Neural Transm. 2004;111(10-11):1303-1315.

Lees AJ Parkinson’s disease and dementia. Lancet. 1985;1(8419):43-44.

Mayeux R. , Stern Y. , Rosenstein R. , et al. An estimate of the prevalence of dementia in idiopathic Parkinson’s disease. J Neurol Neurosurg Psychiatry. 1988 ;45(3):260-262.

Girotti F. , Solvieri P. , Carella F. , et al. Dementia and cognitive impairment in Parkinson’s disease . J Neurol Neurosurg Psychiatry. 1988;51(12):1498-1502.

Ebmeier KP , Calder SA , Crawford JR , Stewart L. , Besson JA , Mutch WJ Clinical features predicting dementia in idiopathic Parkinson’s disease: a follow-up study. Neurology. 1990 ;40(8):1222-1224.

Giladi N. , Treves TA , Paleacu D. , et al. Risk factors for dementia, depression and psychosis in long-standing Parkinson’s disease. J Neural Transm. 2000;107(1):59-71.

Aarsland D. , Andersen K. , Larsen JP , Lolk A. , Nielsen H. , Kragh-Sorensen P. Risk of dementia in Parkinson’s disease: a community-based, prospective study. Neurology. 2001;56(6):730-736.

10.

Hobson P. , Meara J. Risk and incidence of dementia in a cohort of older subjects with Parkinson’s disease in the United Kingdom. Mov Disord . 2004;19(9):1043-1049.

11.

Parashos SA , Maraganore DM , O’Brien PC , Rocca WA Medical services utilization and prognosis in Parkinson’s disease: a population-based study. Mayo Clin Proc. 2002 ;77(9):918-925.

12.

Wielinski CL , Erickson-Davis C. , Wichmann R. , Walde-Douglas M. , Parashos SA Falls and injuries resulting from falls among patients with Parkinson’s disease and other parkinsonian syndromes . Mov Disord. 2005; 20(4):410-415.

13.

Devos H. , Vandenberghe W. , Nieuwboer A. , Tant M. , Baten G. , De Weerdt W. Predictors of fitness to drive in people with Parkinson disease. Neurology. 2007; 69(14):1434-1441.

14.

Bronnick K. , Ehrt U. , Emre M. , et al. Attentional deficits affect activities of daily living in dementia associated with Parkinson’s disease. J Neurol Neurosurg Psychiatry. 2006;77(10):1136-1142.

15.

Nieuwboer A. , De Weerdt W. , Dom R. , Bogaerts K. Prediction of outcome of physiotherapy in advanced Parkinson’s disease. Clin Rehabil. 2002; 16(8): 886-893.

16.

Helm-Estabrooks N. Cognitive Linguistic Quick Test (CLQT): Examiner’s Manual. The Psychological Corporation, San Antonio, TX; 2001.

17.

Folstein MF , Folstein SE , McHugh PR ‘‘ Mini-Mental State ’’: a practical method for grading the cognitive state of patients for the clinician . J Psychiatr Res. 1975 ;12(3): 189-198.

18.

Gelb DJ , Oliver E. , Gilman S. Diagnostic criteria for Parkinson Disease. Arch Neurol . 1999;56(1):33-39.

19.

Tangalos EG , Smith GE , Ivnik RJ , et al. The Mini-Mental State Examination in general medical practice: clinical utility and acceptance . Mayo Clin Proc. 1996; 71(9):829-837.

20.

Hoehn MM , Yahr MD Parkinsonism: onset, progression, and mortality. Neurology . 1967;17(5):427-442.

21.

Beard CM , Kokmen E. , O’Brien PC , Kurland LT The prevalence of dementia is changing over time in Rochester, Minnesota . Neurology. 1995;45(1):75-79.

22.

Stam CJ , Visser SL , Op de Coul AA , et al. Disturbed frontal regulation of attention in Parkinson’s disease. Brain. 1993;116(pt 5):1139-1158.

23.

Woodward TS , Bub DN , Hunter MA Task switching deficits associated with Parkinson’s disease reflect depleted attentional resources . Neuropsychologia . 2002; 40(12):1948-1955.

24.

Hocherman S. , Moont R. , Schwartz M. Recruitment of attentional resources during visuomotor tracking: effects of Parkinson’s disease and age. Brain Res Cogn Brain Res. 2004;21(1):77-86.

25.

Owen AM , Doyon J. , Dagher A. , Sadikot A. , Evans AC Abnormal basal ganglia outflow in Parkinson’s disease identified with PET. Implications for higher cortical functions. Brain . 1998;121(pt 5):949-965.

26.

Brück A. , Kurki T. , Kaasinen V. , Vahlberg T. , Rinne JO Hippocampal and prefrontal atrophy in patients with early non-demented Parkinson’s disease is related to cognitive impairment. J Neurol Neurosurg Psychiatry . 2004;75(10):1467-1469.

27.

Owen AM Cognitive dysfunction in Parkinson’s disease: the role of frontostriatal circuitry. Neuroscientist. 2004; 10(6):525-537.

28.

Cooper JA , Sagar HJ , Jordan N. , Harvey NS , Sullivan EV Cognitive impairment in early, untreated Parkinson’s disease and its relationship to motor disability. Brain. 1991 ;114(pt 5):2095-2122.

29.

Lange KW , Robbins TW , Marsden CD , James M. , Owen AM , Paul GM l-Dopa withdrawal in Parkinson’s disease selectively impairs cognitive performance in tests sensitive to frontal lobe dysfunction. Psychopharmacology. 1992;107(2-3):394-404.

30.

Levy G. , Jacobs DM , Tang MX , et al. Memory and executive function impairment predict dementia in Parkinson’s disease. Mov Disorders. 2002;17(6):1221-1226.

31.

Henry JD , Crawford JR Verbal fluency deficits in Parkinson’s disease: a meta-analysis . J Int Neuropsychol Soc. 2004;10(4):608-622.

32.

Brown RG , Marsden CD How common is dementia in Parkinson’s disease? Lancet . 1984;1(8414):71-83.

33.

Braak H. , Ghebremedhin E. , Rub U. , Bratzke H. , Del Tredici K. Stages in the development of Parkinson’s disease-related pathology . Cell Tissue Res. 2004; 318(1):121-134.

34.

Tam CW , Burton EJ , McKeith IG , Burn DJ , O’Brien JT Temporal lobe atrophy on MRI in Parkinson disease with dementia: a comparison with Alzheimer disease and dementia with Lewy bodies. Neurology . 2005; 64(5): 861-865.