We report a patient with dementia and Klüver-Bucy syndrome who presented 17 years after radiotherapy for nasopharyngeal carcinoma. Computerized tomography of the brain revealed bilateral temporal lobe atrophy. The possibility of delayed effects of radiation brain injury in causing the human Klüver-Bucy syndrome is discussed.
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References
1.
KlüverHBucyPC. Preliminary analysis of functions of the temporal lobes in monkeys. Arch Neurol Psychiatry1939; 42: 9791000
2.
TerzianHDalleOre G.Syndrome of Klüver and Bucy reproduced in man by bilateral removal of the removal of the temporal lobes. Neurology1955; 5: 373380
3.
MarlowWBMancallELThomasTJ. Complete Klüver-Bucy syndrome in man. Cortex1975; 11: 53–59
4.
LillyRCummingsJLBensonFFrankelM. The human Klüver-Bucy syndrome. Neurology1983; 33: 11411145
5.
WooELamKYuYLCerebral radionecrosis: is surgery necessary?J Neurol Neurosurg Psychiatry1987; 50: 14071414
6.
LeeAWM. Complications of radiotherapy. In, van HasseltCAGibbAG, eds. Nasopharyngeal carcinoma. 1st Ed.Hong Kong: The Chinese University Press, 1991: 221233
7.
LeeAWMNgSHHoJHCClinical diagnosis of late temporal lobe necrosis following radiation therapy for nasopharyngeal carcinoma. Cancer1988; 61: 15351542
8.
LeungSFKreelLTsaoSY. Asymptomatic temporal lobe injury after radiotherapy for nasopharyngeal carcinoma: incidence and determinants. Br J Radiology1992; 65: 710714
9.
ParkinAJHunkinNM. Memory loss following radiotherapy for nasopharyngeal carcinoma — an unusual presentation of amnesia. Br J Clin Psychol1991; 30: 349357
10.
ChuCCHuangCCChenHJ. Klüver-Bucy syndrome: report of a case with nasopharngeal cancer after irradiation and chemotherapy. Chin Med J (Taipei)1994; 54: 432435
11.
FolsteinMFFolsteinSEMcHughPR. ‘Mini-mental state’: a practical method for grading the cognitive state of patients of the clinician. J Psychiatr Res1975; 12: 189198
12.
TranelDDamasioAR. Neurobiological foundations of human memory. In: BaddeleyADWilsonBAWattsFN eds. Handbook of memory disorders. 1st Ed.London: John, Wiley and Sons, 1995: 2752
13.
DuffeyPChariGCartlidgeNEFShawPJ. Progressive deterioration of intellect and motor function occurring several decades after cranial irradiation — a new facet in the clinical spectrum of radiation encephalopathy. Arch Neurol1996; 53: 814818
