Abstract
Background
Patients with end-stage renal disease (ESRD) suffer from markedly increased cardiovascular morbidity and mortality. Common carotid artery (CCA) intima-media thickness (IMT) assessment and CCA plaque identification using ultrasound are well-recognized tools for identification and monitoring of atherosclerosis. A new method for monitoring the inflammatory status of plaque, namely radiolabeled interleukin-2 (IL-2) scintigraphy, was proposed recently. The aim of this pilot study was to perform 123I-labeled-IL-2 carotid plaque scintigraphy in ESRD patients treated with peritoneal dialysis and to correlate obtained results with ultrasound assessment of CCA and selected inflammatory markers.
Methods
CCA-IMT was measured and CCA plaques were identified by ultrasound in 10 patients (5 women, 5 men; mean age 62.4 ± 10.4 years; median peritoneal dialysis duration 32.5 months, range 12 – 55 months) with advanced cardiovascular comorbidity. Following CCA ultrasound, 123I-labeled IL-2 carotid plaque scintigraphy was performed. Several biomarkers of inflammation and atherosclerosis were also measured in all patients.
Results
Mean target/non-target ratio for focal 123I-IL-2 uptake within the plaque was 3.15 ± 0.54, and mean IMT from the site of the scintigraphy analysis was 0.975 ± 0.337 mm. Highly significant correlation was found between CCA-IMT and a target/non-target ratio for focal 123I-IL-2 uptake in a corresponding artery (R = 0.92, p = 0.01). However, no significant correlations were found between target/non-target ratio for focal 123I-IL-2 uptake and levels of measured biomarkers.
Conclusions
Our preliminary results suggest potential for identification of an inflamed (vulnerable) plaque using IL-2 scintigraphy in ESRD patients with cardiovascular comorbidities.
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