Changes in the Peritoneal Interstitium and Their Effect on Peritoneal Transport

Transperitoneal transport is a complicated process that includes diffusion and convection across the walls of blood microvessels into tissue interstitium, transport through the interstitium, and final passage across the peritoneum to the dialysis solution in the cavity. The purpose of this paper is to briefly review the normal physiology of this process and then to summarize the events that occur in response to inflammation within the cavity. These events begin with stimulation of macrophages, which in turn secrete cytokines. The cytokines stimulate mesothelial cells and fibroblasts in the tissue to synthesize and secrete other mediators. Those mediators initiate the complex events through which leukocytes migrate from blood vessel lumens through the interstitium and into the cavity. Much of the available data is from model in vitro systems, and therefore in vivo events must be deduced or hypothesized.