Alternatives to Standard Status Asthmaticus Therapy

Even with the currently available treatment, morbidity and mortality from asthma continues to rise. Patients with status asthmaticus who do not respond to standard therapy are at risk for respiratory failure and possible mechanical ventilation. Treatment options for refractory status asthmaticus remain limited and alternative and controversial therapies may need to be considered. Alternative therapies include continuous nebulized beta-agonists, ipratropium bromide, intravenous magnesium sulfate, ketamine, or heliox. Morbidity and mortality may be decreased by increased utilization of these alternative therapies. Pharmacists can play a key role in monitoring and recommending new and alternate therapies.