Background: Recent data demonstrate that moderate consumption of alcohol may be beneficial to cognition. Design: Longitudinal growth curve analyses controlling for variables related to cognition were used to examine the relationship between alcohol consumption, ethnic differences, gender, and cognition over a 4-year-follow-up period. Sample: The sample included 1,836 Japanese American and 2,581 Non-Hispanic White American community-dwelling adults age 65 and older who were cognitively intact at baseline and participated in at least one follow-up examination. Measurement: Cognitive performance was measured using the Cognitive Abilities Screening Instrument (CASI) and reaction time. Results: Current drinkers scored significantly higher on CASI over time than past drinkers or abstainers. The same association between alcohol and CASI was observed in both genders and both ethnic groups. Conclusion: This study provides support regarding the potential beneficial outcomes associated with alcohol consumption and cognition and that these benefits were not modified by gender or ethnicity.
American Psychiatric Association. (1994). Diagnostic and statistical manual of mental disorders (4th ed.). Washington, DC: Author.
2.
Barrett-Connors, E. (1991). Postmenopausal estrogen and prevention bias. Annuals of Internal Medicine, 115, 455-456.
3.
Blazer, D. (1982). The epidemiology of late life depression. Journal of the American Geriatrics Society, 30, 987-992.
4.
Bond, G. E., Burr, R., McCurry, S. M., Rice, M. M., Borenstein-Graves, A., Teri, L., et al. (2003). Alcohol, aging, and cognitive performance: A cross-cultural comparison. Journal of Aging and Health, 15, 371-390.
5.
Bond, G. E., Burr, R. M., McCurry, S. M., Borenstein, A., & Larson, E. B. (2001). Alcohol, aging, and cognition performance in a cohort of Japanese-Americans aged 65 and older: The Kame Project. International Psychogeriatrics, 13, 207-223.
6.
Bretsky, P., Guralnik, J. M., Launer, L., Albert, M., & Seeman, T. E. (2003). The role of APOE-epsilon4 in longitudinal cognitive decline: MacArthur studies of successful aging. Neurology, 60, 1077-1081.
7.
Bryk, A. S., & Raudenbush, S. W. (1992). Hierarchical linear models: Applications and data analysis methods. Newbury Park, CA: Sage.
8.
Carmelli, D., Swan, G. E., Reed, T., Schellenberg, G. D., & Christian, J. C. (1999). The effects of apolipoprotein E epsilon4 in the relationships of smoking and drinking to cognitive function. Neuroepidemiology, 18, 125-133.
9.
Christian, J. C., Reed, T., Carmelli, D., Page, W. F., Norton, J. A., & Breitner, J. S. (1995). Self-reported alcohol intake and cognition in aging twins. Journal of Studies on Alcohol, 56, 414-416.
10.
Correa-Leite, M. L., Nicolosi, A., Cristina, S., Hauser, W. A., & Nappi, G. (2001). Nutrition and cognitive deficit in the elderly: A population study. Journal of Clinical Nutrition, 55, 1053-1058.
11.
Dawson, D. A., Grant, B. F., Chou, S. P., & Pickering, R. P. (1995). Subgroup variation in U.S. drinking patterns: Results of the 1992 National Longitudinal Alcohol Epidemiologic Study. Journal of Substance Abuse, 7, 331-344.
12.
Dent, O. F., Sulway, M. R., Broe, G. A., Creasey, H., Kos, S. C., Jorm, A. F., et al. (1997). Alcohol consumption and cognitive performance in a random sample of Australian soldiers who served in the Second World War. British Medical Journal, 314, 1655-1657.
13.
Dufouil, C., Ducimetiere, P., & Alperovitch, A. (1997). Sex differences in the association between alcohol consumption and cognitive performance. American Journal of Epidemiology, 146, 405-412.
14.
Dufouil, C., Tzourio, C., Brayne, C., Berr, C., Amouyel, P., & Alperovitch, A. (2000). Influence of apolipoprotein E genotype on the risk of cognitive deterioration in moderate drinkers and smokers. Epidemiology, 11, 280-284.
15.
Eckardt, M. J., File, S. E., Gessa, G. L., Grant, K. A., Guerris, C., Hoffman, P. L., et al. (1998). Effects of moderate alcohol consumption on the central nervous system. Alcoholism: Clinical and Experimental Research, 22, 998-1040.
16.
Elias, P. K., Elias, M. F., D’Agostino, R. B., Silbershatz, H., & Wolf, P. A. (1999). Alcohol consumption and cognitive performance in the Framingham Heart Study. American Journal of Epidemiology, 6, 580-589.
17.
Elwood, P. C., Gallacher, E. J., Hopkinson, C. A., Pickering, J., Rabbitt, B., Stollery, B., et al. (1999). Smoking, drinking, and other lifestyle factors and cognitive function in men in the Caerphilly cohort. Journal of Epidemiology and Community Health, 53, 9-14.
18.
Farrer, L. A., Cupples, L. A., Haines, J. L., Hyman, B., Kukull, W. A., Mayeux, R. H., et al. (1997). Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. Journal of the American Medical Association, 278, 1349-1356.
19.
Feskens, E. J., Havekes, L. M., Kalmijn, S., de Knijff, P., Launer, L. J., & Kromhout, D. (1994). Apolipoprotein E allele and cognitive decline in elderly men. British Medical Journal, 309, 1202-1206.
20.
Foote, J. A., Murphy, S. P., Wilkens, L. R., Hankin, J. H., Henderson, B. E., & Kolonel, L. N. (2003). Factors associated with dietary supplement use among healthy adults of five ethnicities: The Multiethnic Cohort Study. American Journal of Epidemiology, 157, 888-897.
21.
Forette, F., Seux, M. L., Thijs, L., Divenah, A. L., Perol, M. B., Rigaud, A. S., et al. (1998). Detection of cerebral aging, an absolute need: Predictive value of cognitive status. European Neurology, 39(Suppl. 1), 2-6.
22.
Frezza, M., DiPadova, C., Pozzato, G., Terpin, M., Baraona, E., & Lieber, C. S. (1990). High blood alcohol levels in women: The role of decreased gastric alcohol dehydrogenase activity and first-pass metabolism. New England Journal of Medicine, 322, 95-99.
23.
Galanis, D. J., Joseph, C. L., Masaki, K. H., Petrovitch, H., Ross, G. W., & White, L. (2000). A longitudinal study of drinking and cognitive performance in elderly Japanese-American men: The Honolulu Asia Aging Study. American Journal of Public Health, 90(110), 1254-1259.
24.
Gilbert, J., & Collins, L. (1997). Ethnic variation in women’s and men’s drinking. In R. W. Wilsnack & S. C. Wilsnack (Eds.), Gender and alcohol: Individual and social perspectives. (pp. 357-378). New Brunswick, NJ: Rutgers Center of Alcohol Studies.
25.
Graves, A. B., Larson, E. B., Edland, S. D., Bowan, J. D., McCormick, W. C., McCurry, S. M., et al. (1996). Prevalence of dementia and its subtypes in the Japanese American population of King County, Washington State: The Kame Project. American Journal of Epidemiology, 144, 760-771.
26.
Graves, A. B., Larson, E. B., Kukull, W. A., White, L. R., & Teng, E. L. (1993). Screening for dementia in the community in cross-national studies: Comparison between the Cognitive Abilities Screening Instrument and the Mini-Mental State Examination. In B. Corain, K. Iqbal, M. Nicolini, B. Winblad, B. Wisniewski, & P. Zatta (Eds.). Alzheimer’s Disease: Advances in clinical and basic research (pp. 114-119). New York: John Wiley.
27.
Graves, A. B., Rajaram, L., Bowen, J. D., McCormick, W. C., McCurry, S. M., & Larson, E. B. (1999). Cognitive decline and Japanese culture in a cohort of older Japanese Americans in King County, WA: the Kame Project. Journal of Gerontology B Psychological Social Sciences, 3, 154-161.
28.
Hebert, L. E., Scherr, P. A., Beckett, L. A., Albert, M. S., Rosner, B., Taylor, J. O., et al. (1993). Relation of smoking and low to moderate alcohol consumption to change in cognitive function: A longitudinal study in a defined community of older persons. American Journal of Epidemiology, 137, 881-891.
29.
Heien, D. (1996). The relationship between alcohol consumption and earnings. Journal of Studies of Alcohol, 57, 536-542.
30.
Hendrie, H. C., Gao, S., Hall, K. S., Hui, S. L., & Unverzagt, F. W. (1996). The relationship between alcohol consumption, cognitive performance, and daily functioning in an urban sample of older Black Americans. Journal of American Geriatrics Society, 44, 1158-1165.
31.
Howard, B. V., Gidding, S. S., & Liu, K. (1998). Association of apolipoproteinE phenotype with plasma lipoproteins in African-American and White young adults: The CARDIA Study: Coronary Artery Risk Development in Young Adults. American Journal of Epidemiology, 148, 859-868.
32.
Huijbregts, P. P., Feskens, E. J., Rasanen, L., Alberti-Fidanza, A., Nissinen, A., Giampaoli, S., et al. (1998). Dietary patterns and cognitive function in elderly men in Finland, Italy, and the Netherlands. European Journal of Clinical Nutrition, 11, 826-831.
33.
Jepson, R. G., Fowkes, F. G., Donnan, P. T., & Housley, E. (1995). Alcohol intake as a risk factor for peripheral arterial disease in the general population in the Edinburgh Artery Study. European Journal of Epidemiology, 11, 9-14.
34.
Kohout, F. J., Berkman, L. F., Evans, D. A., & Cornoni-Huntley, J. (1993). Two shorter forms of the CES-D depression symptoms index. Journal of Aging and Health, 5(2), 179-193.
35.
Kolonel, L. N., Henderson, B. E., Hankin, J. H., Nomura, A. M. Y., Wilkens, L. R., Pike, M. C., et al. (2000). A multiethnic cohort in Hawaii and Los Angeles: Baseline characteristics. American Journal of Epidemiology, 151, 346-357.
36.
Kukull, W. A., Higdon, R., Bowen, J. D., McCormick, W. C., Teri, L., Schellenberg, G. D., et al. (2002). Dementia and Alzheimer disease incidence. Archives of Neurology, 59, 1737-1746.
37.
Laforge, R., Williams, G. D., & Dufour, M. C. (1990). Alcohol consumption, gender, and self-reported hypertension. Drug and Alcohol Dependence, 26, 235-249.
38.
Lezak, M. D. (1995). Neuropsychological Assessment (3rd ed.). New York: Oxford University Press.
39.
Liu, H. C., Chou, P., Lin, K. N., Wang, S. J., Fuh, J. L., Lin, H. C., et al. (1994). Assessing cognitive abilities and dementia in a predominantly illiterate population of older individuals in Kinmen. Psychological Medicine, 24, 763-770.
40.
Mann, K., Batra, A., Gunthner, A., & Schroth, G. (1992). Do women develop alcoholic brain more readily than men?Alcohol and Clinical Experimental Research, 16, 1052-1056.
41.
Massman, P. J., Delis, D. C., Butters, N., Dupont, R. M., & Gillin, J. C. (1992). The subcortical dysfunction model of memory deficits in depression: Neuropsychological validation on a subgroup of patients. Journal of Clinical and Experimental Neuropsychology, 12, 729-744.
42.
McCurry, S. M., Edland, S. D., Teri, L., Kukull, W. A., Bowen, J. D., McCormick, W. C., et al. (1999). The cognitive abilities screening instrument (CASI): Data from a cohort of 2,524 cognitively intact elderly. International Journal of Geriatric Psychiatry, 14, 882-888.
43.
Mukamal, K. J., Kuller, L. H., Fitzpatrick, A. L., Longstreth, W. T., Mittleman, M. A., & Siscovick, D. S. (2003). Prospective study of alcohol consumption and risk of dementia in older adults. Journal of the American Medical Association, 289, 1405-1413.
44.
National Institute on Alcohol Abuse and Alcoholism. (1997). Alcohol and health (Ninth special report to the U.S. Congress). Washington, DC: U.S. Department of Health and Human Services.
45.
Parker, E. S., & Noble, E. P. (1977). Alcohol consumption and cognitive functioning in social drinkers. Journal of Studies on Alcohol, 38, 1224-1232.
46.
Parker, E. S., Parker, D. A., & Harford, T. C. (1991). Specifying the relationship between alcohol use and cognitive loss: The effects of frequency of consumption and psychological distress. Journal of Studies on Alcohol, 52, 366-373.
47.
Ruitenberg, A., van Swieten, J. C., Witteman, J. C., Mehta, K. M., van Duijn, C. M., Hofman, A., et al. (2002). Alcohol consumption and risk of dementia: The Rotterdam Study. Lancet, 359, 281-286.
48.
Schinka, J. A., Vanderploeg, R. D., Rogish, M., Graves, A. B., Mortimer, J. A., & Ordoric, P. I. (2003). Effects of the use of alcohol and cigarettes on cognition in elderly Africian-American adults. Journal of International Neuropsychology Society, 9, 690-697.
49.
Teng, E. L. (1990a, March). The 3RT Test. Paper presented at the Fourth Japan-U.S. Workshop on Methods for Cross Cultural Research on Dementia conference, Honolulu, HI.
50.
Teng, E. L. (1990b). The 3RT Test: Three reaction time tasks for IBM PC computers. Behavior Research Methods, Instruments, and Computers, 22, 389-392.
51.
Teng, E. L., Chui, H. C., & Saperia, D. (1990). Senile dementia: Performance on a neuropsychological test battery. Recent Advances in Cardiovascular Diseases, 11 (Suppl. 1), 27-34.
52.
Teng, E. L., Hasegawa, K., Homma, A., Imai, Y., Larson, E., Graves, A., et al. (1994). The Cognitive Abilities Screening Instrument (CASI): A practical test for cross-cultural epidemiological studies of dementia. International Psychogeriatrics, 6, 45-58.
53.
van Buuren, S., & Oudshoorn, C. G. M. (June, 2000). Multivariate imputation by chained equations: MICE V1.0 user’s manual (Netherlands Organization for Applied Scientific Research TNO Prevention and Health Report, PG/VGZ/00.038). Leiden: Netherlands Organization for Applied Scientific Research.
54.
Waugh, M., Jackson, M., Fox, G. A., Hawke, S. H., & Tuck, R. R. (1989). Effects of social drinking on neuropsychological performance. British Journal of Addiction, 84, 659-667.
55.
Willis, F., Graff-Radford, N., Pinto, M., Lawson, L., Adamson, J., Epstein, D., et al. (2003). Apolipoproteinepsilon4 allele frequency in young Africans of Ugandan descent versus African Americans. Journal of the National Medical Association, 95, 71-76.
