Micro channels are widely used in different industries. The investgations on heat transfer improvments of these instruments are of significant inportance. At hte present study, the influence of different nano-fluids and geometrical charectrestics on the thermal performance of a heat sink which is especially for for micro-channels are investigated. In the present study, the authors investigated the Nusselt number and pressure drop in differential geometries and Reynolds numbers (Re). Then the micro-channel was investigated with different heat flux (q).In the first step, the micro-channel was examined and the final numerical results showed that the hexagonal cross-section can improve heat transfer about 9%. At the second step and after selecting appropriate parameters, the effect of three nano-particles (Al2O3 - CuO- TiO2) were studied. The results presented that aluminum oxide (Al2O3) has the best heat transfer rate among the mentioned nano-fluids. With the presence of nano-particles (Al2O3, φ = 4%) an increment of 40% in heat transfer rate, for the hexagonal cross section was achieved compare to rectangular cross section with water as working fluid.
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