Synthesis and anti-HIV-1 Activity of [1-[2′,5′-Bis- O -( Tert -Butyldimethylsilyl)-β-L-Ribofuranosyl]Thymine]-3′-Spiro-5″-(4″-Amino-1″,2″-Oxathiole-2″,2″-Dioxide) (L-TSAO-T),the L-enantiomer of the Highly Specific HIV-1 Reverse Transcriptase Inhibitor TSAO-T
Free accessResearch articleFirst published online December, 1995
Synthesis and anti-HIV-1 Activity of [1-[2′,5′-Bis- O -( Tert -Butyldimethylsilyl)-β-L-Ribofuranosyl]Thymine]-3′-Spiro-5″-(4″-Amino-1″,2″-Oxathiole-2″,2″-Dioxide) (L-TSAO-T),the L-enantiomer of the Highly Specific HIV-1 Reverse Transcriptase Inhibitor TSAO-T
The L-isomer of the potent HIV-1-RT inhibitor TSAO-T has been stereospecifically synthesized and tested for its ‘in vitro’ antiretroviral activity against HIV-1. Unlike the D-isomer, the L-isomer did not show appreciable inhibition of HIV-1 replication. The cytotoxicity was comparable with the cytotoxicity of the D-enantiomer.
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