Current and Future Management of Herpes Zoster

Herpes zoster (shingles) is a common disease affecting approximately three in 1000 of the population per year and up to 10 in 1000 per year in the elderly population. This incidence is likely to increase as the proportion of elderly people in the general population increases and various forms of immunosuppression become more common, e.g. following organ transplantation. Management of both the acute and chronic pain is probably the most important part of caring for shingles patients. Antiviral therapy, anti-inflammatory steroids and sympathetic nerve blocks are the main measures used during the acute phase to prevent the development of postherpetic neuralgia (PHN). Antiviral agents given early in the acute phase of herpes zoster are generally the therapy of choice and there is also growing evidence for benefit with tricyclic antidepressants. Pain relief once PHN has developed is generally much less effective. Many classes of drug have been investigated for the management of PHN and some have been found to be helpful in some patients. There is as yet no generally effective agent, however preventive antiviral therapy early in the course of herpes zoster is recommended for all elderly patients since they have a high risk of developing severe PHN.