1 The clinical findings are reported of 15 members of three families living in houses where relatively large amounts of pentachlorophenol (PCP) solutions had been applied. To be able to interprete the plasma concentrations in the patients, plasma-PCP-concentrations in 99 draftees were measured. The clinical and toxicological-analytical results are discussed.
2 Signs of a systemic PCP-intoxication were not found in any patient.
3 Symptoms and objective changes of the uncovered skin were present in three patients (a burning painful sensation, erythema, dryness and scaling) possibly caused by a direct influence of PCP in the air.
4 The plasma-PCP-concentrations in the patients ranged from 25-660 μgl-1. The mean plasma-PCP-concentrations in the draftees was 128.6±134.9μgl -1 (mean±s.d.); the median was 88 μg1-1, the 95% range was 330 μg1-1.
5 There was an association between patients' plasma-PCP-concentrations and their staying in the affected house.
Armstrong, R.W., Eicher, E.R., Klein, D.E., Barthel, W.F., Bennet, J.V., Johnson, V., Brue, H. & Loveless, L.E. (1969). Pentachlorophenol poisoning in a nursery for newborn infants. II. Epidemiologic and toxicologic studies . J. Pediatrics, 75, 317-325.
4.
Arsenault, R.D. (1976). Pentachlorophenol and contained chlorinates dibenzodioxins in the environment. J. Am. Wood-Preserv. Ass., 72, 122.
5.
Barthel, W.F., Curley, A., Thrasher, C.L., Sedlak, V.A. & Armstrong, R. (1969). Determination of pentachlorophenol in blood, urine, tissue and clothing. J. Ass. Offic. Ann. Chem., 52, 294-298.
6.
Bevenue, A. & Beckman, H. (1967). Pentachlorophenol: A discussion of its properties and its occurrence as a residue in human and animal tissue. Residue Rev., 19, 83-129.
7.
Brandt, M., Schmidt, E. & Schmidt, F.W. (1977). Chronische Lebererkrankung durch langjährige Intoxication im Haushalt mit Pentachlorphenol: Verhandlungen der Deutsche Gesellschaft für innere Medizin, Wiesbaden 17-21. April 1977, pp.1609-1611. Müchen: J. F. Bergmann Verlag.
8.
Buser, H.R. & Bosshardt, H.P. (1976). Determination of polychlorinated dibenzo-p-dioxins and dibenzofurans in commercial pentachlorophenols by combined gas chromatography-mass spectrometry. J. Ass. Offic. Ann. Chem., 59, 562-569.
9.
Casarett, L.J., Bevenue, W.L., Yauger, W.L. & Whalen, S.A. (1969). Observations on pentachlorophenol in human blood and urine. Am. Ind. Hyg. Ass. J., 30, 360-366.
10.
Cirelli, D.P. (1978). Pentachlorophenol. U.S. Fed. Reg. , 43, 48446-48447.
11.
Cranmer, M. & Freal, J. (1970). Gas chromatographic analysis of pentachlorophenol in human urine by formation of alkyl esters. Life Sci., II, 9, 121-128.
12.
Crosby, D.G. (1981). Environmental chemistry of pentachlorophenol. Pure & appl. Chem., 53, 1051-1080.
13.
Engst, R., Macholz, R.M. & Kujawa, M. (1976). The metabolism of hexachlorobenzene in rats. Bull. envir. contam. Toxicol., 16, 248-252.
14.
Gebefügi, I. & Parlar, H. (1978). Zur Risikoabschatzung von Pentachlorphenol in der Umwelt. Gesellschaft für Strahlen- und Umweltforschung mBH; GSF-Bericht Ö414, P67, Müchen.
15.
Haley, T.J. (1977). Human poisoning with pentachlorophenol and its treatment. Ecotoxicol. envir. Safety, 1, 343-347.
16.
Jirasek, L., Kalensky, J., Kubec, K., Pazderova, J. & Lukas, E. (1976). Chlorakne, porphyria cutanea tarda und andere Intoxicationen durch Herbizide. Hautarzt, 27, 328-333.
17.
Johnson, R.D. & Manske, D.D. (1977). Pesticide and other chemical residues in total diet samples (XI). Pest. mon. J., 11, 116-132.
18.
Johnson, R.L., Gehring, P.J., Kociba, R.J. & Schwetz, B.A. (1973). Chlorinated dibenzodioxins and pentachlorophenol. Envir. Health Perspect., 5, 171-175.
19.
Klaschka, F. von, Nieding, G. von & Walter, R. (1979). Zur Frage der Hautsensibilisierung durch Pentachlorphenol-haltige Holzschutzmittel. Zbl. Arbeitsmed., 29, 150-154.
Rao, K. R. Ed. (1977). Pentachlorophenol New York and London: Plenum Press.
22.
Rivers, J.B. (1972). Gas chromatographic determination of pentachlorophenol in human blood and urine. Bull. envir. contam. Toxicol., 8, 294-296.
23.
Roberts, H.J. (1963). Aplastic anemia due to pentachlorophenol and tetrachlorophenol . Southern. med. J., 56, 632-639.
24.
Schwetz, B.A., Keeler, P.A. & Gehring, P.J. (1974). The effect of purified and commercial grade pentachlorophenol on rat embryonal and fetal development. Toxicol. appl. Pharmacol. , 28, 151-161.
25.
Wakimoto, T., Tachikawa, R. & Ogawa, T. (1972). Gas liquid chromatographic determination of residues of the herbicide pentachlorophenol in the environment by derivatization with dimethylsulphate. Nippon Dojo Hirogaka Lasshi, 43, 344-348.
26.
Wegman, R.C.C. & Hofstee, A.W.M. (1979). Chlorophenols in surface waters of the Netherlands. Water. Res., 13, 651-657.
27.
Woiwode, W., Wodarz, R., Drysch, K. & Weichardt, H. (1980). Bestimmung von freiem Pentachlorphenol in der Luft und im Blut durch leistungsfähige Routineverfahren. Int. Arch. occup. envir. Health, 45, 153-161.
