1 Arterial-venous plasma concentration differences of meprobamate were studied on admission of acute overdose in man.
2 The patients were divided in two groups. In the control group (n= 25) two successive blood samples were collected from the same vessel. In the study group ( n = 35) femoral arterial and venous blood samples were collected simultaneously.
3 In the control group the differences were not significant. In the study group the differences were statistically significant (P < 0.01).
4 The present study suggests that the origin of blood samples should be stated for toxicological studies and that the toxicokinetics may be more complex than those recognized previously.
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