The influence of pharmacological pretreatment on efficacy of HI-6 oxime in combination with benactyzine in soman poisoning in rats

Abstract

1 The influence of pharmacological pretreatment (pyr idostigmine, benactyzine and trihexyphenidyle), de signated PANPAL, on soman-induced cholinergic and stressogenic effects as well as on the efficacy of antidotal treatment (HI-6 plus obidoxime) in rats was studied.

2 PANPAL prophylaxis significantly decreased soman- induced cholinesterase inhibition in blood, brain and diaphragm as well as stressogenic effects of soman (an increase in plasma corticosterone level and liver tyrosine aminotransferase activity).

3 PANPAL pretreatment did not improve the efficacy of HI-6 in combination with benactyzine on soman- induced anticholinesterase and stressogenic effects.

4 These findings confirm that PANPAL prophylaxis can improve prognosis of soman poisoning especially by protection of cholinesterases.

Keywords

soman PANPAL pretreatment HI-6 benactyzine acetylcholinesterase corticosterone tyrosine aminotransferase

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