Lack of association of mannose-binding lectin gene polymorphisms with development and clinical manifestations of systemic lupus erythematosus in Chinese children
Restricted accessResearch articleFirst published online April, 2009
Lack of association of mannose-binding lectin gene polymorphisms with development and clinical manifestations of systemic lupus erythematosus in Chinese children
Mannose-binding lectin (MBL) gene polymorphisms may be associated with adult-onset systemic lupus erythematosus (SLE), but studies in children with SLE are rare. This study tested the genetic association between MBL polymorphisms and paediatric-onset SLE in a cohort of Chinese children in Taiwan. In all 150 children with SLE and 100 healthy controls of comparable age were genotyped for codon 52, 54 and 57 mutations of the MBL gene using a polymerase chain reaction–based assay. Clinical manifestations, organ involvement, disease activity, laboratory characteristics and outcome were recorded and compared between patients with different MBL genotypes. Codon 54 mutation was fairly common in both SLE patients and controls, whereas codon 52 and codon 57 mutations were not detected in our study subjects. No statistically significant differences were found in allele frequencies of the codon 54 mutation between SLE and control groups. Moreover, no association was found between this MBL polymorphism and clinical manifestations, organ involvement, disease activity, laboratory characteristics or outcome of SLE. These results suggest that MBL polymorphisms do not influence susceptibility to paediatric-onset SLE and do not influence clinical manifestations of SLE in Chinese children.
2 Tsutsumi A Takahashi R Sumida T . Mannose binding lectin: genetics and autoimmune disease. Autoimmun Rev2005; 4: 364–372.
3.
3 Walport MJ Davies KA Botto M . C1q and systemic lupus erythematosus. Immunobiology1998; 199: 265–285.
4.
4 Turner MW . The role of mannose-binding lectin in health and disease. Mol Immunol2003; 40: 423–429.
5.
5 Klein NJ . Mannose-binding lectin: do we need it? Mol Immunol2005; 42: 919–924.
6.
6 Jack DL Read RC Tenner AJ Frosch M Turner MW Klein NJ . Mannose-binding lectin regulates the inflammatory response of human professional phagocytes to Neisseria meningitidis serogroup B. J Infect Dis2001; 184: 1152–1162.
7.
7 Lee YH Witte T Momot T . The mannose-binding lectin gene polymorphisms and systemic lupus erythematosus: two case-control studies and a meta-analysis. Arthritis Rheum2005; 52: 3966–3974.
8.
8 Seelen MA van der Bijl EA Trouw LA . A role for mannose-binding lectin dysfunction in generation of autoantibodies in systemic lupus erythematosus. Rheumatology2005; 44: 111–119.
9.
9 Saevarsdottir S Kristjansdottir H Grondal G Vikingsdottir T Steinsson K Valdimarsson H . Mannan-binding lectin and complement C4A in Icelandic multicase families with systemic lupus erythematosus. Ann Rheum Dis2006; 65: 1462–1467.
10.
10 Sullivan KE Wooten C Goldman D Petri M . Mannose-binding protein genetic polymorphisms in black patients with systemic lupus erythematosus. Arthritis Rheum1996; 39: 2046–2051.
11.
11 Ip WK Chan SY Lau CS Lau YL . Association of systemic lupus erythematosus with promoter polymorphisms of the mannose-binding lectin gene. Arthritis Rheum1998; 41: 1663–1668.
12.
12 Piao W Liu CC Kao AH . Mannose-binding lectin is a disease-modifying factor in North American patients with systemic lupus erythematosus. J Rheumatol2007; 34: 1506–1513.
13.
13 Huang JL Yao TC See LC . Prevalence of pediatric systemic lupus erythematosus and juvenile chronic arthritis in a Chinese population: a nation-wide prospective population-based study in Taiwan. Clin Exp Rheumatol2004; 22: 776–780.
14.
14 Brunner HI Gladman DD Ibañez D Urowitz MD Silverman ED . Difference in disease features between childhood-onset and adult-onset systemic lupus erythematosus. Arthritis Rheum2008; 58: 556–562.
15.
15 Carreno L Lopez-Longo FJ Monteagudo I . Immunological and clinical differences between juvenile and adult onset of systemic lupus erythematosus. Lupus1999; 8: 287–292.
16.
16 Tan EM Cohen AS Fries JF . The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum1982; 25: 1271–1277.
17.
17 Hochberg MC . Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum1997; 40: 1725 (letter).
18.
18 Bombardier C Gladman DD Urowitz MB Caron D Chang CH . Derivation of the SLEDAI: a disease activity index for lupus patients. The Committee on Prognosis Studies in SLE. Arthritis Rheum1992; 35: 630–640.
19.
19 Mosca M Bombardieri S . Assessing remission in systemic lupus erythematosus. Clin Exp Rheumatol2006; 24: 100–104.
20.
20 Liao CH Yao TC Chung HT See LC Kuo ML Huang JL . Polymorphisms in the promoter region of RANTES and the regulatory region of monocyte chemoattractant protein-1 among Chinese children with systemic lupus erythematosus. J Rheumatol2004; 31: 2062–2067.
21.
21 Baca V Velazquez-Cruz R Salas-Martinez G Espinosa-Rosales F Saldana-Alvarez Y Orozco L . Association analysis of the PTPN22 gene in childhood-onset systemic lupus erythematosus in Mexican population. Genes Immun2006; 7: 693–695.
22.
22 von Scheven E Elder ME . Association between beta2-glycoprotein I gene polymorphisms and pediatric SLE and antiphospholipid antibodies. Lupus2005; 14: 440–444.
23.
23 Horiuchi T Tsukamoto H Morita C . Mannose binding lectin (MBL) gene mutation is not a risk factor for systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) in Japanese. Genes Immun2000; 1: 464–466.
24.
24 Lau YL Lau CS Chan SY Karlberg J Turner MW . Mannose-binding protein in Chinese patients with systemic lupus erythematosus. Arthritis Rheum1996; 39: 706–708.
25.
25 Jakab L Laki J Sallai K . Association between early onset and organ manifestations of systemic lupus erythematosus (SLE) and a down-regulating promoter polymorphism in the MBL2 gene. Clin Immunol2007; 125: 230–236.
26.
26 Takahashi R Tsutsumi A Ohtani K . Association of mannose binding lectin (MBL) gene polymorphism and serum MBL concentration with characteristics and progression of systemic lupus erythematosus. Ann Rheum Dis2005; 64: 311–314.
27.
27 Bertoli AM Fernandez M McGwin G . Systemic lupus erythematosus in a multiethnic US cohort: XXXVI. Influence of mannose-binding lectin exon 1 polymorphisms in disease manifestations, course, and outcome. Arthritis Rheum2006; 54: 1703–1704.
28.
28 Huang YF Wang W Han JY . Increased frequency of the mannose-binding lectin LX haplotype in Chinese systemic lupus erythematosus patients. Eur J Immunogenet2003; 30: 121–124.
29.
29 Tsutsumi A Sasaki K Wakamiya N . Mannose-binding lectin gene: polymorphisms in Japanese patients with systemic lupus erythematosus, rheumatoid arthritis and Sjogren’s syndrome. Genes Immun2001; 2: 99–104.
