The overlap of systemic lupus erythematosus and sickle cell disease: report of two cases and a review of the literature

Abstract

Two cases of Afro-Caribbean women with an association of sickle cell disease (SCD) and systemic lupus erythematosus (SLE) are presented. We discuss the clues to the diagnosis of this combination with a review of the literature. Owing to a substantial overlap between the clinical manifestations of the two disorders, the diagnosis of SLE in patients with SCD may be difficult to establish and is often delayed.

Keywords

sickle cell disease systemic lupus erythematosus

Get full access to this article

View all access options for this article.

References

Appenzeller S. , Fattori A. , Saad ST , Costallat LT Systemic lupus erythematosus with sickle cell disease. Clin Rheumatol 2008; 27: 359-364.

Michel M. , Habibi A. , Godeau B. , et al. Characteristics and outcome of connective tissue diseases in patients with sickle-cell disease: report of 30 cases. Semin Arthritis Rheum 2008; 38: 228-240.

Oqunbiyi AO , George AO , Brown O. , Okafor BO Diagnostic and treatment difficulties in systemic lupus erythematosus coexisting with sickle cell disease. West Afr J Med 2007 ; 26: 152-155.

Nader A. , Khalidi NA , Ajmani H. , Varga J. coexisting systemic lupus erythematosus and sickle cell disease. A diagnostic and therapeutic challenge. J Clin Rheumatol 2005; 11: 86-92.

Saxena VR , Mina R. , Moallem HJ , Rao SP , Miller ST Systemic lupus erythematosus in children with sickle cell disease. J Pediatr Hematol Oncol 2003; 25: 668-671.

Shetty AK , Baliga MR , Gedalia A. , Warrier RP Systemic lupus erythematosus and sickle cell disease. Indian J Pediatr 1998; 65: 618-621.

Eissa MM , Lawrence JM III , McKenzie L. , Little FM , Mankad VN , Yang YM Systemic lupus erythematosus in a child with sickle cell disease. South Med J 1995; 88: 1176-1178.

Katsanis E. , Hsu E. , Koon-Hung L. , McKee JA Systemic Lupus Erythematosus and Sickle Hemoglobinopathies: a report of two cases and review of the literature. Am J Hematol 1987; 25: 211-214.

Warrier RP , Sahney S. , Walker H. Hemoglobin sickle cell disease and systemic lupus erythematosus. J Nate Med Assoc 1984; 76: 1030-1031.

10.

Luban NL , Boeckx RL , Barr O. Sickle cell anemia and SLE. J Pediatr 1980 ; 96: 1120.

11.

Karthikeyan G. , Wallace SL , Blum L. SLE and sickle cell disease. Arthritis Rheum 1978; 21: 862-863.

12.

Wilson WA , Nicholson GD , Hughes GR , Amin S. , Alleyne G. , Serjeant GR Hemoglobin Sickle Cell Disease and Systemic Lupus Erythematosus. Br Med J 1976; 1: 813.

13.

Wilson FM , Clifford GO , Wolf PL Lupus erithematosus associated with sickle cell anemia. Arthritis Rheum 1964; 7: 443-449.

14.

Baethge BA , Bordelon TR , Mills GM , Bowen LM , Wolf RE , Bairnsfather L. Antinuclear antibodies in sickle cell disease. Acta Haematol 1990; 84: 186-189.