Association of TNFSF4 rs1234315,rs2205960 polymorphisms and systemic lupus erythematosus susceptibility: a meta-analysis

Abstract

Background

The aim of this study was to explore the association between tumor necrosis factor superfamily number 4 (TNFSF4) rs1234315, rs2205960 polymorphisms and systemic lupus erythematosus (SLE) susceptibility.

Methods

A meta-analysis was performed on the association between rs1234315 and rs2205960 polymorphisms and SLE by allelic contrast, additive model, recessive model and dominant model.

Results

Regarding rs1234315 polymorphism, a total of five studies were included (6575 cases, 14,798 controls). Meta-analysis showed significant associations between the T allele and SLE in overall subjects and Asians (OR = 1.310, 95%CI: 1.104–1.553, p = 0.002; OR = 1.458, 95%CI: 1.328–1.602, p < 0.001). With respect to the rs2205960 polymorphism, significant associations between the T allele and SLE were found in all subjects (OR = 1.333, 95%CI: 1.254–1.418, p < 0.001), Asians (OR = 1.407, 95%CI: 1.345–1.471, p < 0.001) and Europeans (OR = 1.254, 95%CI: 1.185–1.328, p < 0.001). Results also showed significant associations between the additive model and SLE in all subjects and Asians (OR = 1.934, 95%CI: 1.500–2.494, p < 0.001; OR = 1.882, 95%CI: 1.318–2.689, p = 0.001). Furthermore, we detected significant associations between the dominant model and SLE in all subjects and Asians (OR = 1.421, 95%CI: 1.239–1.629, p < 0.001; OR = 1.297, 95%CI: 1.083–1.555, p = 0.005). Significant associations were found between the recessive model and SLE in overall subjects and Asians (OR = 1.677, 95%CI: 1.312–2.144, p < 0.001; OR = 1.751, 95%CI: 1.235–2.483, p = 0.002).

Conclusion

The present study suggested that TNFSF4 rs1234315 and rs2205960 polymorphisms were associated with SLE susceptibility.

Keywords

Tumor necrosis factor superfamily number 4 lupus polymorphism

Get full access to this article

View all access options for this article.

References

Tan

MKX

Heng

TYJ

Mak

. The potential use of metformin, dipyridamole, N-acetylcysteine and statins as adjunctive therapy for systemic lupus erythematosus. Cells 2019; 8: pii: E323–pii: E323.

Zhu

Xie

Qin

, et al. Interaction between IL-33 gene polymorphisms and current smoking with susceptibility to systemic lupus erythematosus. J Immunol Res 2019; 2019: 1547578–1547578.

Meng

Zhang

, et al. Genetic polymorphisms near IL-21 gene associated with Th17 cytokines confer risk for systemic lupus erythematosus in Chinese Han population. Lupus 2019; 28: 406–413.

Cortini

Ellinghaus

Malik

, et al. B cell OX40L supports T follicular helper cell development and contributes to SLE pathogenesis. Ann Rheum Dis 2017; 76: 2095–2103.

Ding

, et al. Preparation, characterization and application of anti-human OX40 ligand (OX40L) monoclonal antibodies and establishment of a sandwich ELISA for autoimmune diseases detection. Int Immunopharmacol 2019; 67: 260–267.

Sitrin

Suto

Wuster

, et al. The Ox40/Ox40 ligand pathway promotes pathogenic Th cell responses, plasmablast accumulation, and lupus nephritis in NZB/W F1 mice. J Immunol 2017; 199: 1238–1249.

Jia

. The rs3850641 polymorphism of the TNFSF4 gene increases the risk of myocardial infarction in a Chinese Han population. Biosci Rep 2018; 38: pii: BSR20180526–pii: BSR20180526.

Croft

. The role of TNF superfamily members in T-cell function and diseases. Nat Rev Immunol 2009; 9: 271–285.

Manku

Langefeld

Guerra

, et al. Trans-ancestral studies fine map the SLE-susceptibility locus TNFSF4. PLoS Genet 2013; 9: e1003554–e1003554.

10.

Ramser

Eichelberger

Däster

, et al. High OX40 expression in recurrent ovarian carcinoma is indicative for response to repeated chemotherapy. BMC Cancer 2018; 18: 425–425.

11.

Cortini

Ellinghaus

Malik

, et al. B cell OX40L supports T follicular helper cell development and contributes to SLE pathogenesis. Ann Rheum Dis 2017; 76: 2095–2103.

12.

Jacquemin

Schmitt

Contin-Bordes

, et al. OX40 ligand contributes to human lupus pathogenesis by promoting T follicular helper response. Immunity 2015; 42: 1159–1170.

13.

Gwyer Findlay

Danks

Madden

, et al. OX40L blockade is therapeutic in arthritis, despite promoting osteoclastogenesis. Proc Natl Acad Sci U S A 2014; 111: 2289–2294.

14.

Ueno

Blanco

. OX40/OX40L axis: Not a friend in autoimmunity. Oncotarget 2015; 6: 21779–21780.

15.

Zhou

Nath

, et al. Gene-gene interaction of BLK, TNFSF4, TRAF1, TNFAIP3, and REL in systemic lupus erythematosus. Arthritis Rheum 2012; 64: 222–231.

16.

Aten

Roos

Claessen

, et al. Strong and selective glomerular localization of CD134 ligand and TNF receptor-1 in proliferative lupus nephritis. J Am Soc Nephrol 2000; 11: 1426–1438.

17.

Cunninghame Graham

Graham

Mankku

, et al. Polymorphism at the TNF superfamily gene TNFSF4 confers susceptibility to systemic lupus erythematosus. Nat Genet 2008; 40: 83–89.

18.

Yang

Shen

, et al. Genome-wide association study in Asian populations identifies variants in ETS1 and WDFY4 associated with systemic lupus erythematosus. PLoS Genet 2010; 6: e1000841–e1000841.

19.

Chua

Ooh

Chai

. TNFSF4 polymorphisms are associated with systemic lupus erythematosus in the Malaysian population. Int J Immunogenet 2016; 43: 303–309.

20.

Gateva

Sandling

Hom

, et al. A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus. Nat Genet 2009; 41: 1228–1233.

21.

Gupta

Kumar

Pratap

, et al. Association of ITGAM, TNFSF4, TNFAIP3 and STAT4 gene polymorphisms with risk of systemic lupus erythematosus in a North Indian population. Lupus 2018; 27: 1973–1979.

22.

Lee

Song

. Associations between TNFSF4 and TRAF1-C5 gene polymorphisms and systemic lupus erythematosus: A meta-analysis. Hum Immunol 2012; 73: 1050–1054.

23.

Yang

, et al. Association of TNFSF4 polymorphisms with systemic lupus erythematosus: A meta-analysis. Mod Rheumatol 2013; 23: 686–693.

24.

Han

Zheng

Cui

, et al. Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus. Nat Genet 2009; 41: 1234–1237.

25.

Wang

, et al. Influence of the TNFSF4 rs1234315 polymorphism in the susceptibility to systemic lupus erythematosus and rheumatoid arthritis. Hum Immunol 2019; 80: 270–275.

26.

Zhang

Han

Sun

, et al. A single-nucleotide polymorphism of the TNFSF4 gene is associated with systemic lupus erythematosus in Chinese Han population. Rheumatol Int 2011; 31: 227–231.

27.

Chang

Yang

Zhao

, et al. Association of BANK1 and TNFSF4 with systemic lupus erythematosus in Hong Kong Chinese. Genes Immun 2009; 10: 414–420.

28.

Sánchez

Comeau

Freedman

, et al. Identification of novel genetic susceptibility loci in African American lupus patients in a candidate gene association study. Arthritis Rheum 2011; 63: 3493–3501.

29.

Sanchez

Webb

Rasmussen

, et al. Genetically determined Amerindian ancestry correlates with increased frequency of risk alleles for systemic lupus erythematosus. Arthritis Rheum 2010; 62: 3722–3729.

30.

Zhou

Cheng

, et al. A replication study from Chinese supports association between lupus-risk allele in TNFSF4 and renal disorder. Biomed Res Int 2013; 2013: 597921–597921.