Associations of four common VDR polymorphisms with rheumatoid arthritis and systemic lupus erythematosus: evidence from a meta-analysis

Abstract

Associations of polymorphisms in vitamin D receptor (VDR) with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) have already been explored by many studies. The aim of this meta-analysis was to better clarify associations between polymorphisms in VDR and RA/SLE by combing the results of all relevant studies. Eligible studies were searched from Pubmed, Embase, WOS and CNKI. We used Review Manager to combine the results of eligible studies. Thirty-seven studies were included in this meta-analysis. VDR rs1544410 (recessive comparison: odds ratio (OR) = 1.36, 95% confidence interval (CI) 1.06–1.76; over-dominant comparison: OR = 0.81, 95% CI 0.71–0.93) and rs731236 (over-dominant comparison: OR = 0.77, 95% CI 0.63–0.94) polymorphisms were found to be significantly associated with RA in overall combined analyses. Besides, VDR rs1544410 (dominant comparison: OR = 0.61, 95% CI 0.46–0.82; over-dominant comparison: OR = 1.45, 95% CI 1.16–1.81; allele comparison: OR = 0.75, 95% CI 0.62–0.92), rs2228570 (dominant comparison: OR = 0.58, 95% CI 0.50–0.67; recessive comparison: OR = 1.57, 95% CI 1.21–2.03; allele comparison: OR = 0.69, 95% CI 0.60–0.80) and rs731236 (dominant comparison: OR = 0.69, 95% CI 0.50–0.96; allele comparison: OR = 0.80, 95% CI 0.70–0.90) polymorphisms were also found to be significantly associated with SLE in overall combined analyses. Subgroup analyses revealed that significant associations for VDR polymorphisms and RA/SLE were mainly driven by Asians. Collectively, this meta-analysis proved that VDR rs7975232, rs1544410, rs2228570 and rs731236 polymorphisms may confer susceptibility to RA and SLE, especially for Asians.

Keywords

Vitamin D receptor (VDR)polymorphisms rheumatoid arthritis (RA)systemic lupus erythematosus (SLE)meta-analysis

Get full access to this article

View all access options for this article.

References

Charles

Britt

Pan

. Rheumatoid arthritis. Aust Fam Physician 2013; 42: 765.

Fortuna

Brennan

. Systemic lupus erythematosus: Epidemiology, pathophysiology, manifestations, and management. Dent Clin North Am 2013; 57: 631–655.

Alamanos

Drosos

. Epidemiology of adult rheumatoid arthritis. Autoimmun Rev 2005; 4: 130–136.

Rees

Doherty

Grainge

Lanyon

Zhang

. The worldwide incidence and prevalence of systemic lupus erythematosus: A systematic review of epidemiological studies. Rheumatology (Oxford) 2017; 56: 1945–1961.

Viatte

Barton

. Genetics of rheumatoid arthritis susceptibility, severity, and treatment response. Semin Immunopathol 2017; 39: 395–408.

Mohan

Putterman

. Genetics and pathogenesis of systemic lupus erythematosus and lupus nephritis. Nat Rev Nephrol 2015; 11: 329–341.

Trochoutsou

Kloukina

Samitas

Xanthou

. Vitamin-D in the immune system: Genomic and non-genomic actions. Mini Rev Med Chem 2015; 15: 953–963.

Sassi

Tamone

D’Amelio

. Vitamin D: Nutrient, hormone, and immunomodulator. Nutrients 2018; 10: E1656.

Raphael

Nalawade

Eagar

Forsthuber

. T cell subsets and their signature cytokines in autoimmune and inflammatory diseases. Cytokine 2015; 74: 5–17.

10.

Astry

Harberts

Moudgil

. A cytokine-centric view of the pathogenesis and treatment of autoimmune arthritis. J Interferon Cytokine Res 2011; 31: 927–940.

11.

Moher

Liberati

Tetzlaff

Altman

. PRISMA group. Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. Ann Intern Med 2009; 151: 264–269.

12.

Stang

. Critical evaluation of the Newcastle–Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol 2010; 25: 603–605.

13.

Uitterlinden

Fang

Van Meurs

Pols

Van Leeuwen

. Genetics and biology of vitamin D receptor polymorphisms. Gene 2004; 338: 143–156.

14.

Valdivielso

Fernandez

. Vitamin D receptor polymorphisms and diseases. Clin Chim Acta 2006; 371: 1–12.

15.

Nishi

Milner

Jr Giovannucci

, et al. Integration of molecular pathology, epidemiology and social science for global precision medicine. Expert Rev Mol Diagn 2016; 16: 11–23.

16.

Mohammadi

Aslani

Mostafaei

Jamshidi

Riahi

Mahmoudi

. Are genetic variations in IL-21-IL-23R-IL-17A cytokine axis involved in a pathogenic pathway of rheumatoid arthritis? Bayesian hierarchical meta-analysis. J Cell Physiol 2019; 234: 17159–17171.

17.

Xie

, et al. Association of oestrogen receptor alpha gene polymorphisms with systemic lupus erythematosus risk: An updated meta-analysis. Microb Pathog 2019; 127: 352–358.

18.

Huang

, et al. Association of angiotensin-converting enzyme insertion/deletion polymorphism with susceptibility to systemic lupus erythematosus: A meta-analysis. Int J Rheum Dis 2018; 21: 447–457.

Supplementary Material

Please find the following supplemental material available below.

For Open Access articles published under a Creative Commons License, all supplemental material carries the same license as the article it is associated with.

For non-Open Access articles published, all supplemental material carries a non-exclusive license, and permission requests for re-use of supplemental material or any part of supplemental material shall be sent directly to the copyright owner as specified in the copyright notice associated with the article.

0.00 MB

0.92 MB

0.30 MB