Phototesting and photoprotection in LE

Abstract

Photosensitivity and induction of skin lesions following UV radiation is a common problem of patients with cutaneous and systemic forms of lupus erythematosus. The detrimental effect of UV radiation to patients with lupus erythematosus was already recognized in the last century. Skin lesions can now be provoked under standardized conditions allowing the diagnosis and classification of patients with photosensitive disorders. The aim of this review is to give an overview on the history, test procedure and test results in patients with lupus erythematosus.

Keywords

phototesting photosensitivity lupus erythematosus photoprotection

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References

Gilliam JN , Sontheimer RD Skin manifestations of SLE. Clin Rheum Dis 1981; 8: 207—218.

Tan EM , Cohen AS , Fries JF The 1982 revised criteria for the classification of systemic lupus erythematosus . Arthritis Rheum 1982; 25: 1271-1277.

Gilliam JN , Sontheimer RD Distinctive cutaneous subsets in the spectrum of lupus erythematosus. JAm Acad Dermatol 1981; 4: 471-475.

Sontheimer RD , Thomas JR , Gilliam JN Subacute cutaneous lupus erythematosus. Arch Dermatol 1979; 115: 1409-1415.

David-Bajar KM Subacute cutaneous lupus erythematosus. J Invest Dermatol 1993 ; 100: 2S-8S.

Kind P. , Lakomek HJ , Goerz G. Kutaner Lupus erythematodes. Die Internistische Welt 1987; 4: 92-99.

Arnold HL Lupus erythematosus profumdus (Kaposi-Irgang). Arch Dermatol Syph 1948; 196: 196-203.

Kind P. , Goerz G. Der kutane Lupus erythematodes. In: Macher E , Knop J , Bröcker EB (eds). Jahrbuch der Dermatologie. Dr. Biermann Verlagsgesellschaft, Münster 1988, pp 88-103.

Tuffanelli DL Discoid lupus erythematosus. Clin Rheum Dis 1985; 8: 327-341.

10.

O'Loughlin S. , Schroeter AL , Jordon RE A study of lupus erythematosus with particular reference to generalized discoid lupus. Br J Dermatol 1978; 99: 1-11.

11.

Kind P. , Lehmann P. Photobiologie des Lupus erythematodes. Hautarzt 1990; 41: 66-71.

12.

Kind P. , Lehmann P. , Plewig G. Phototesting in lupus erythematosus. J Invest Dermatol 1993; 100: 53S-7S.

13.

Becker MM , Wang Z. Origin of ultraviolet damage in DNA. J Mol Biol 1989; 210: 429-438.

14.

Peak MJ , Peak JG , Carnes BA Induction of direct and indirect single-strand breaks in human DNA by far- and near-ultraviolet radiations: action spectrum and mechanisms. Photochem Photobiol 1987; 45: 381-387.

15.

Baeuerle PA , Henkel T. Function and activation of NF-kB in the immune system . Annu Rev Immunol 1994; 12: 141-179.

16.

Golan et al. Solar ultraviolet radiation induces enhanced accumulation of oxygen radicals in murine SLE-derived splenocytes in vitro. Lupus 1994; 3: 103—106.

17.

Sauder DN , Wong D. , Laskin C. Epidermal cytokines in murine lupus. J Invest Dermatol 1993; 100: 42S—46S.

18.

Furukawa F. , Lyon MB , Norris DA Susceptible cytotoxicity to ultraviolet B light in fibroblasts and keratinocytes cultured from autoimmune-prone MRL/Mp-lpr/lpr mice. Clin Immunol Immunopathol 1989; 52: 460-472.

19.

Furukawa F. , Kanauchi H. , Imamura S. Susceptibility to UVB light in cultured keratinocytes of cutaneous lupus erythematosus . Dermatology 1994; 189: 18S-23S.

20.

Messer G. , Weiss EH , Baeuerle PA Tumor necrosis factor β (TNF-β) induces binding of the NF-kB transcription factor to a high-affinity kB element in the TNF-β promoter. Cytokine 1990; 2: 389-397.

21.

Bazzoni F. et al. Analysis of tumor necrosis factor promoter responses to ultraviolet light. J Clin Invest 1994; 93: 56—62.

22.

Ansel J. et al. Cytokine modulation of keratinocyte cytokines. J Invest Dermatol 1990; 94: 101S-107S.

23.

Garmyn M. et al. Effect of aging and habitual sun exposure on the genetic response of cultured human keratinocytes to solar-simulated irradiation. J Invest Dermatol 1992; 99: 743-748.

24.

Sontheimer RD Photoimmunology of lupus erythematosus and dermatomyositis: a speculative review. Photochem Photobiol 1996; 63: 583-594.

25.

Norris DA Pathomechanisms of photosensitive lupus erythematosus. J Invest Dermatol 1993; 100: 58S 68S.

26.

Hruza LL , Pentland AP Mechanism of UV-induced inflammation. J Invest Dermatol 1993 ; 100: 35S-41S.

27.

Streilein JW Sunlight and skin-associated lymphoid tissues (SALT): If UVB is the trigger and TNFα is its mediator, what is the message . J Invest Dermatol 1993; 100: 47S-52S.

28.

Bielsa et al. Histopathologic findings in cutaneous lupus erythematosus. Arch Dermatol 1994; 130: 54-58.

29.

de Jong Emgj , van Erp Pej , Ruiter DJ , van de Kerkhof Pcm. Immunohistochemical detection of proliferation and differentiation in discoid lupus erythematosus . J Am Acad Dermatol 1991; 25: 1032-1038.

30.

Provost TT , Reichlin M. Immunopathologic studies of cutaneous lupus erythematosus. J Clin Immunol 1988; 8: 223-233.

31.

Kind P. , Goerz G. Histologie des Lupus erythematodes. In: Holzmann H (ed). Dermatologie und Rheuma. Springer : Berlin, 1987, pp 278-283.

32.

Watanabe T. , Tsuchida T. Classification of lupus erythematosus based upon cutaneous manifestations. Dermatology 1995; 190: 277-283 .

33.

Bangert JL , Freeman RG , Sontheimer RD , Gilliam JN Subacute cutaneous lupus erythematosus and discoid lupus erythematosus. Arch Dermatol 1984; 120: 332—337.

34.

Ansel JC et al. Effects of UV radiation on autoimmune strains of mice: increased mortality and accelerated autoimmunity in BXSB male mice. J Invest Dermatol 1985; 85: 181-186.

35.

Walchner M. , Leib-Mösch C. , Messer G. , Kind P. Endogene retrovirale Sequenzen als Faktor in der Pathogenese des systemischen Lupus erythematodes. Hautarzt 1996; 47: 502-509.

36.

McGrath H. , Bak E. , Michalski JP Ultraviolet-A light prolongs survival and improves function in (New Zealand black x New Zealand White) F1 hybrid mice. Arthritis Rheum 1987; 30: 557-561.

37.

Cazenave A. Lupus erythemateux. Ann Mal Peau Syph 1851; 3: 298-303.

38.

Kaposi MK Neue Beiträge zur Kenntnis des Lupus erythematodes. Arch Dermatol Syph 1872; 1: 36-78.

39.

Hutchinson J. Harveian lectures on lupus. Br J Med 1888; 1: 113-118.

40.

MacLeod JMH. Lupus erythematosus. Some observations on its etiology. Arch Dermatol Syph 1924; 9: 1-12.

41.

Freund H. Inwiefern ist der lupus erythematodes von allgemeinen Faktoren abhängig. Dermatol Wschr 1929; 30: 1939-1946.

42.

Fuhs E. Lupus erythematodes subacutus mit ausgesprochener Uberempfindlichkeit gegen Quarzlicht. Zentrbl Hautkr 1929; 30: 308-309.

43.

Kesten BM , Slatkin M. Diseases related to light sensitivity. Arch Dermatol 1953; 67: 284-301.

44.

Jesionek A. Richtlinien der modernen Lichttherapie. Strahlentherapie 1916; 7: 41-65.

45.

Davidson AM Quinine bisulfate as desensitizing agent in the treatment of lupus erythematosus. Arch Dermatol Syph 1938; 37: 247-253.

46.

Zarafonetes Cjd , Greken RH , Curtis AC Further studies on treatment of lupus erythematosus with sodium-para-aminobenzoate. J Invest Dermatol 1948; 11: 359-381.

47.

Garzon R. , Ferraris L. , Cancio C.

Contribucion el estudio experimental del lupus eritematoso. Rev Argent

Dermatol 1949; 33: 106-118.

48.

Epstein JH , Tuffanelli DL , Dubois EL Light sensitivity and lupus erythematosus. Arch Dermatol 1965; 91: 483-485.

49.

Baer RL , Harber LC Photobiology of lupus erythematosus. Arch Dermatol 1965; 92: 124-128.

50.

Everett MA , Olson RL Response of cutaneous lupus erythematosus to ultraviolet light. J Invest Dermatol 1965; 44: 133-139.

51.

Freeman RG , Knox JM , Owens DW Cutaneous lesions of lupus erythematosus induced by monochromatic light. Arch Dermatol 1969; 100: 677-682.

52.

Cripps DJ , Rankin J. Action spectra of lupus erythematosus and experimental immunofluorescence . Arch Dermatol 1973; 107: 563-567.

53.

Emerit I. , Michelson M. Mechanism of photosensitivity in systemic lupus erythematosus patients. Proc Natl Acad Sci USA 1981; 78: 2537-2540.

54.

Lester RS , Burnham TK , Fine G. , Murray K. Immunologic concepts of light reactions in lupus erythematosus and polymorphous light eruptions. Arch Dermatol 1967; 96: 1-10.

55.

LeFeber WP et al. Ultraviolet light induces binding of antibodies to selected nuclear antigens on cultured human keratinocytes. J Clin Invest 1984; 74: 1545-1551.

56.

Casciola-Rosen LA , Anhalt G. , Rosen A. Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes . J Exp Med 1994; 179: 1317-1330.

57.

Rosen A. , Casciola-Rosen L. , Ahearn J. Novel packages of viral and self-antigens are generated during apoptosis. J Exp Med 1995; 181: 1557-1561.

58.

Hölzle E. , Plewig GG , Lehmann P. Photodermatoses: diagnostic procedures and their interpretation. Photodermatology 1987; 4: 109-114.

59.

Wucherpfennig V. Zur Messung und Bemessung des Ultraviolett . Klin Wschr 1942; 21: 926-930.

60.

Lehmann P. et al. Experimental reproduction of skin lesions in lupus erythematosus . J Am Acad Dermatol 1990; 22: 181-187.

61.

van Weelden H. , Velthuis PJ , Baart de la Faille H. Light-induced skin lesions in lupus erythematosus: photobiological studies. Arch Derm Res 1989; 281: 470-474.

62.

Higuchi D. , Ogura Y. , Watanabe H. , Takiuchi I. Experimental production of DLE lesion with a single exposure to UVB (2.7 MEDs) radiation. J Dermatol 1991; 18: 545-548.

63.

George PM , Kuskowski M. , Schmidt C. Trends in photoprotection in American fashion magazines, 1983-1993. J Am Acad Dermatol 1996; 34: 424-428.

64.

Pathak MD Sunscreens: Topical and systemic approaches for protection of human skin against harmful effects of solar radiation. J Am Acad Dermatol 1982; 7: 285-312.

65.

Taylor CR , Stem RS , Leyden JJ , Gilchrest BA Photoageing/ photodamage and photoprotection. J Am Acad Dermatol 1990; 22: 1-15.

66.

Owens DW , Knox JM , Hudson HT , Troll D. Influence of wind on ultraviolet injury. Arch Dermatol 1974; 109: 200-201.

67.

Algra RJ , Knox JM Topical photoprotective agents. Int J Dermatol 1978; 17: 628-633.

68.

Fisher AA Sunscreen dermatitis due to glyceryl PABA: significance of cross reactions to this PABA ester. Cutis 1976; 18: 495-496.

69.

Allison JL , O'Brien RL , Hahn FE DNA reactions with chloroquine. Science 1965 ; 149: 1111-1113.

70.

Dubois EL Antimalarials in the management of discoid and systemic lupus erythematosus . Semin Arthr 1978; 8: 33-51.

71.

Wallace DJ , Linker-Israeli M. , Metzger AL , Stecher VJ The relevance of antimalarial therapy with regard to thrombosis, hypercholesterolemia and cytokines in SLE. Lupus 1993; 2: 13S-15S.

72.

Fisher GJ et al. Molecular basis of sun-induced ageing and retinoid antagonism . Nature 1996; 379: 335-359.

73.

Berk SH , Blank H. Ultraviolet light and cytoplasmic tubules in lupus erythematosus. Arch Dermatol 1974; 109: 364-366.

74.

Beutner EH et al. Studies on criteria of the European Academy of Dermatology and Venerology for the classification of cutaneous lupus erythematosus. Int J Dermatol 30: 411-417, published erratum 1991 30 557.

75.

Nived O. , Johansen PB , Sturfelt G. Standardized ultraviolet-A exposure provokes skin reaction in systemic lupus erythematosus. Lupus 1993; 2: 247-250.

76.

Davis P. , Atkins B. , Hughes Grv. Antibodies to native DNA in discoid lupus erythematosus. Br J Dermatol 1974; 91: 175—181.

77.

Dubois EL Lupus Erythematosus. 2nd ed, University of Southern California Press: Los Angeles , 1974.

78.

Callen JP , Klein J. Subacute cutaneous lupus erythematosus: Clinical, serologic, immunogenetic, and therapeutic considerations in seventy-two patients. Arthritis Rheum 1988; 31: 1007-1013.

79.

Mody GM et al. High mortality with systemic lupus erythematosus in hospitalized African Blacks. Br J Rheum 1994; 33: 1151-1153.

80.

Pande I. et al. Analysis of clinical and laboratory profile in Indian childhood systemic lupus erythematosus and its comparison with SLE in adults. Lupus 1993; 2: 83-87.