A Bayesian approach towards the identification of latent subgroups

Abstract

In clinical trials, it is often of interest to know whether treatment works differently for some groups than others, known as heterogeneity of treatment effect. Such subgroup analysis is complicated to conduct because trials are typically not powered to find subgroups. Furthermore, it is difficult to identify characteristics of patients pertaining to such subgroups. In this article, we propose a semiparametric mixture model to identify subgroups with time-to-event outcomes. Specifically, we assume a proportional hazards model with subgroup-specific piecewise constant baseline hazards, where the subgroup-specific treatment effect is assumed to be the same within each subgroup. The probability of belonging to a certain subgroup is a function of patient prognostic factors. Adopting a Bayesian approach, classification uncertainty is taken into account. We demonstrate the utility of our approach via simulation and an application to data from a real clinical trial in HIV research.

Keywords

Bayesian inference mixture models subgroup analysis survival analysis heterogenous treatment effect

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