The samurai chemist Jokichi Takamine (1854–1922) crystallized adrenalin, the first hormone to be isolated in the twentieth century, from the adrenal medulla, in the summer of 1900. This paper reviews Takamine's route to the discovery of adrenalin and presents historical photographs and documents collected in Kanazawa, Japan, where he grew up, and the United States, where he made his major discoveries.
References
1.
KawasakiKK. Jokichi Takamine — A Record of His American Achievement. New York: William Edwin Rudge, 1928.
2.
TakamineJ.Adrenalin, the active principle of the suprarenal glands, and its mode of preparation. American Journal of Pharmacy1901; 73: 523–31.
3.
AbelJJ. Ueber den blutdruckerregenden Bestandtheil der Nebenniere, das Epinephrin. Hoppe-Seylers Zeitschrift für Physiologische Chemie1899; 28: 318–62.
4.
AldrichTB. A preliminary report on the active principle of the suprarenal gland. American Journal of Physiology1901; 5: 457–61.
5.
YamashitaA.Research note on adrenaline by Keizo Uenaka in 1900. Biomedical Research2002; 23: 1–10.
6.
BennettJW. Takamine — Documents from the Dawn of Industrial Biotechnology. Indiana: Elkhart, 1988.
7.
AbelJJ. Chemistry in relation to biology and medicine with especial reference to insulin and other hormones. Science1927; 66: 307–19, 337–46.
