Ranitidine is a H2 receptor blocker and rarely cause bradycardia. A 28 years old male patient attended the emergency department for urticaria. He was given 45 mg of phenyramine and 50 mg of ranitidine intravenously. He then complained of dizziness and developed bradycardia and hypotension. Electrocardiogram detected junctional bradycardia rhythm. He was given 0.5 mg atropine intravenously and his rhythm then returned to normal. His symptoms subsided and the blood pressure improved. Ranitidine is a frequently used medication and this case illustrated a rare but serious side-effect of the medication.
NahumE., ReishO., NaoN., MerlobP.Ranitidine-induced bradycardia in a neonate - a first report. Eur J Pediatr1993; 152(11): 933–4.
7.
BallerD., HuchzermeyerH.Histamine effects on the heart with special reference to cardiac side effects of H2 receptor antagonists. Klin Wochenschr1989; 67(15): 743–55.
8.
MatsudaN., JesminS., TakahashiY., HattaE., KobayashiM., MatsuyamaK.Histamine H1 and H2 receptor gene and protein levels are differentially expressed in the hearts of rodents and humans. J Pharmacol Exp Ther2004; 309(2): 786–95.
