This article explores the ways spirituality intertwines with the health and culture of those living in the Appalachian region. Nursing has long considered the value of spirituality and faith, noting its complex connections with health and illness. Literature pertaining to spirituality, health, and the culture of those residing in the Appalachian region was reviewed. Although the review suggests that connections between spirituality and health exist, empirical evidence is limited, somewhat dated, and lacks viable conclusions relative to the diverse needs of the Appalachian population. Focused research that addresses strongly linked operationally defined variables is needed to strengthen the evidence for clarity about distinct applications to practice.
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