Orthodontic Treatment of a Kabuki Syndrome Patient

Abstract

Kabuki syndrome (KS) is a rare disorder characterized by somatic and psychological disturbances including special face morphology, skeletal anomalies, and other systemic disorders. Because of the diverse clinical manifestation, the management of a patient with KS may involve several medical and dental specialists, including orthodontics. The aim of the article is to present successful orthodontic treatment performed in a 14-year-old boy diagnosed with the KS. Dental relations and smile aesthetics were normalized after orthodontic treatment; however, problems with patient compliance and cooperation and an increased risk of root resorption may influence treatment outcomes. Interdisciplinary cooperation between medical and dental specialists is essential in patients with KS.

Keywords

dental anomalies Kabuki syndrome orthodontic treatment rare disease root resorption

Get full access to this article

View all access options for this article.

References

Atar

Lee

O’Donell

. Kabuki syndrome: oral and general features seen in a 2 years-old Chinese boy. Int J Paediatr Dent. 2006;16(3):222–226.

Bokinni

. Kabuki syndrome revisited. J Hum Genet. 2012;57(4):223–227.

Cogulu

Oncag

Celen

Ozkinay

. Kabuki syndrome with additional dental findings: a case report. J Dent Child (Chic). 2008;75(2):185–187.

do Prado Sobral

Leite

Figueiredo

Ferrari

Safatle

Cordoba

Versiani

Acevedo

Mestrinho

. Craniofacial and dental features in Kabuki syndrome patients. Cleft Palate Craniofac J. 2013;50:440–447.

dos Santos

Ribeiro

Stuani

Silva

FWGP

de Quireoz

. Kabuki Make-up (Niikawa-Kuroki) syndrome: dental and craniofacial findings in Brazilian child. Braz Dent J. 2006;17(3):249–254.

Kim

Cho

Maeng

Sohn

Kim

Jin

. A novel MLL2 gene mutation in a Korean patient with Kabuki syndrome. Korean J Pediatr. 2013;56(8):355–358.

Lung

Rennie

. Kabuki syndrome: a case report. J Orthod. 2006;33(4):242–245.

Makrythanasis

van Bon

Steehouwer

Rodríguez-Santiago

Simpson

Dias

Anderlid

Arts

Bhat

Augello

. MLL2 mutation detected in 86 patients with Kabuki syndrome; a genotype-phenotype study. Clin Genet. 2013;84(6):539–545.

Matsune

Shimizu

Tohma

Asada

Ohashi

Maeda

. Craniofacial and dental characteristics of Kabuki syndrome. Am J Med Genet. 2001;98(2):185–190.

10.

Niikawa

Kuroki

Kajii

Matsuura

Ishikiriyama

Tonoki

Ishikawa

Yamada

Fujita

Umemoto

. Kabuki make-up (Niikawa-Kuroki) syndrome: a study of 62 patients. Am J Med Genet. 1988;31(3):565–589.

11.

Petzold

Kratzsch

Opitz

Tinschert

. The Kabuki syndrome: four patients with oral abnormalities. Eur J Orthod. 2003;25(1):13–19.

12.

Rocha

Peixoto

ITA

Fernandez

Torres

Queiroz

. Dental finding in Kabuki make-up syndrome: a case report. Spec Care Dentist. 2008;28:53–57.

13.

Spano

Campus

Bortone

Lai

Luglie

. Oral features in Kabuki make-up syndrome. Eur J Paediatr Dent. 2008;9:149–152.

14.

Suarez Guerrero

Ordonez Suarez

Contreras Garcia

. Kabuki syndrome [in Spanish]. An Pediatr (Barc). 2012;77:51–56.

15.

Szczepanik

Obersztyn

Kruk

Jastrzebska-Janas

. Kabuki syndrome with epilepsy onset at the age of 13 years. A case report [in Polish]. Child Neurology. 2006;15:69–74.

16.

Teixeira

Silva

Honjo

Bertola

Albano

Kim

. Dental evaluation of Kabuki syndrome patients. Cleft Palate Craniofac J. 2009;46:668–673.

17.

Tuna

Marsan

Gencay

Seymen

. Craniofacial and dental characteristics of Kabuki syndrome: nine years cephalometric follow-up. J Clin Pediatr Dent. 2012;36(4):393–400.

18.

White

Thompson

Kidd

Savarirayan

Turner

Amor

Delatycki

Fahey

Baxendale

White

. Growth, behavior, and clinical findings in 27 patients with Kabuki (Niikawa-Kuroki) syndrome. Am J Med Genet A. 2004;127A(2):118–127.

19.

Zarate

Zhan

Jones

. Infrequent manifestations of Kabuki syndrome in a patient with novel MLL2 mutation. Mol Syndromol. 2012;3(4):180–184.