Comparison Between Treacher Collins Syndrome and Pierre Robin Sequence: A Cephalometric Study

Abstract

Objective:

The aim of this study was to compare the dentoskeletal pattern of Treacher Collins syndrome (TCS) and nonsyndromic Pierre Robin sequence (PRS).

Design:

Retrospective.

Setting:

Single center.

Patients:

Eighteen patients diagnosed with TCS (Group TCS) or PRS (Group PRS) in rehabilitation treatment at a single center. Group TCS was composed of 9 patients (4 male, 5 female) with a mean age of 12.9 years (standard deviation = 4.8). Group PRS was composed of 9 patients paired by age and sex with group TCS.

Main Outcome Measure(s):

Cone beam computed tomography–derived cephalometric images taken before the orthodontic or the orthodontic-surgical treatment were analyzed using Dolphin Imaging (Dolphin Imaging 11.0 & Management Solutions). Variables evaluating the cranial base, the maxillary and mandibular skeletal components, maxillomandibular relationship, the vertical components and the dentoalveolar region were measured. Intergroup comparisons were performed using t tests. The significance level considered was 5%.

Results:

Intergroup differences in the mandible size and growth pattern were observed. Group TCS showed a smaller mandibular length (Co-Go, Co-Gn) and a higher palatal plane (SN-Palatal Plane) and mandibular plane angles (SN-Go.Gn) compared to group PRS. No differences between TCS and PRS were observed for the sagittal position of the maxilla, maxillomandibular relationship, and dental components.

Conclusions:

Treacher Collins syndrome presented a decreased mandible and a more severe vertical growth pattern compared to PRS.

Keywords

cephalometry Pierre Robin sequence craniofacial morphology mandibulofacial dysostosis

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References

Arvystas

Shprintzen

. Craniofacial morphology in Treacher Collins syndrome. Cleft Palate Craniofac J. 1991;28(2):226–230.

Bacher

Goz

Pham

Cornelius

Speer

Goelz

Arand

Wendling

Buchner

, et al. Three-dimensional computer morphometry of the maxilla and face in infants with Pierre Robin sequence—a comparative study. Cleft Palate Craniofac J. 2000;37(3):292–302.

Behrents

McNamara

Avery

. Prenatal mandibulofacial dysostosis (Treacher Collins syndrome). Cleft Palate Craniofac J. 1977;14(1):13–34.

Bush

Williams

. Incidence of the robin anomalad (Pierre Robin syndrome). Br J Plast Surg. 1983;36(4):434–437.

Chung

Levi

Hyun

Montoro

Lisiecki

James

Steven Buchman

Michael

Derrick

. Pierre Robin sequence and Treacher Collins hypoplastic mandible comparison using three-dimensional morphometric analysis. J Craniofac Surg. 2012;23(7 suppl 1):1959–1963.

Dahl

Kreiborg

Bjork

. A morphologic description of a dry skull with mandibulofacial dysostosis. Scan J Dent Res. 1975;83(5):257–266.

Daskalogiannakis

Ross

Tompson

. The mandibular catch-up growth controversy in Pierre Robin sequence. Am J Orthod Dentofac Orthop. 2001;120(3):280–285.

Dauria

Marsh

. Mandibular distraction osteogenesis for Pierre Robin sequence: what percentage of neonates need it? J Craniofac Surg. 2008;19(5):1237–1243.

Elliott

Studen-Pavlovich

Ranalli

. Prevalence of selected pediatric conditions in children with Pierre Robin sequence. Pediatr Dent. 1995;17(2):106–111.

10.

Esenlik

Plana

Grayson

Flores

. Cephalometric predictors of clinical severity in Treacher Collins syndrome. Plast Reconstr Surg. 2017;140(6):1240–1249.

11.

Fazen

Elmore

Nadler

. Mandibulo-facial dysostosis. (Treacher-Collins syndrome). Am J Dis Child. 1967;113(4):405–410.

12.

Figueroa

Glupker

Fitz

BeGole

. Mandible, tongue, and airway in Pierre Robin sequence: a longitudinal cephalometric study. Cleft Palate Craniofac J. 1991;28(4):425–434.

13.

Grayson

Weintraub

Bookstein

McCarthy

JG.

A comparative cephalometric study of the cranial base in craniofacial anomalies: part I: tensor analysis. Cleft Palate Craniofac J. 1985;22(2):75–87.

14.

Herring

Rowlatt

Pruzansky

. Anatomical abnormalities in mandibulofacial dysostosis. Am J Med Genet. 1979;3(3):225–229.

15.

Johnson

Moonis

Green

Carmody

Burbank

. Syndromes of the first and second branchial arches, part 1: embryology and characteristic defects. AJNR Am J Neuroradiol. 2011a;32(1):14–19.

16.

Johnson

Moonis

Green

Carmody

Burbank

. Syndromes of the first and second branchial arches, part 2: syndromes. AJNR Am J Neuroradiol. 2011b;32(2):230–237.

17.

Kapadia

Shetye

Grayson

McCarthy

. Cephalometric assessment of craniofacial morphology in patients with Treacher Collins syndrome. J Craniofac Surg. 2013;24(4):1141–1145.

18.

Krimmel

Kluba

Breidt

Bacher

Dietz

Buelthoff

Siegmar

. Three-dimensional assessment of facial development in children with Pierre Robin sequence. J Craniofac Surg. 2009;20(6):2055–2060.

19.

Kumar

Ludlow

Soares Cevidanes

Mol

. In vivo comparison of conventional and cone beam CT synthesized cephalograms. Angle Orthod. 2008;78(5):873–879.

20.

Kumar

Ludlow

Mol

Cevidanes

. Comparison of conventional and cone beam CT synthesized cephalograms. Dentomaxillofac Radiol. 2007;36(5):263–269.

21.

Laitinen

Ranta

. Cephalometric measurements in patients with Pierre Robin syndrome and isolated cleft palate. Scand J Plast Reconstr Surg Hand Surg. 1992;26(2):177–183.

22.

Shi

Wang

Zheng

. The comparative study of craniofacial structural characteristic of individuals with different types of cleft palate. Ann Plast Surg. 2007;59(4):382–387.

23.

Ludlow

Gubler

Cevidanes

Mol

. Precision of cephalometric landmark identification: cone-beam computed tomography vs conventional cephalometric views. Am J Orthod Dentofac Orthop. 2009;136(3):312 e1-10.

24.

Mackay

. Controversies in the diagnosis and management of the Robin sequence. J Craniofac Surg. 2011;22(2):415–420.

25.

Magalhães

da Silveira

Moreira

Cavalcanti

MGP

. Clinical and imaging correlations of Treacher Collins syndrome: report of two cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007;103(6):836–842.

26.

Marsh

Celin

Vannier

Gado

. The skeletal anatomy of mandibulofacial dysostosis (Treacher Collins syndrome). Plast Reconstr Surg. 1986;78(4):460–470.

27.

Matsuda

Suda

Motohashi

Tsuji

Ohyama

. Skeletal characteristics and treatment outcome of five patients with Robin sequence. Angle Orthod. 2006;76(5):898–908.

28.

Ozawa

Lorenzoni

de Oliveira

da Silva Filho

. Facial profile evaluation of isolated Pierre robin sequence. Cleft Palate Craniofac J. 2012;49(5):546–552.

29.

Posnick

al-Qattan

Moffat

Armstrong

. Cranio-orbito-zygomatic measurements from standard CT scans in unoperated Treacher Collins syndrome patients: comparison with normal controls. Cleft Palate Craniofac J. 1995;32(1):20–24.

30.

Printzlau

Andersen

. Pierre Robin sequence in Denmark: a retrospective population-based epidemiological study. Cleft Palate Craniofac J. 2004;41(1):47–52.

31.

Roberts

Pruzansky

Aduss

. An x-radiocephalometric study of mandibulofacial dysostosis in man. Arch Oral Biol. 1975;20(4):265–281.

32.

Robin

. La chute de la base de la langue consideree comme une nouvelle cause de gene dans la respiration naso-pharyngienne. Bull Acad Med. 1923;89:37–41.

33.

Rogers

Lim

Mulliken

Padwa

. Effect of a syndromic diagnosis on mandibular size and sagittal position in Robin sequence. J Oral Maxillofac Surg. 2009;67(11):2323–2331.

34.

Rovin

Dachi

Borenstein

Cotter

. Mandibulofacial dysostosis, a familial study of five generations. J Pediatr. 1964;65:215–221.

35.

Shen

Vargervik

Oberoi

Chigurupati

. Facial skeletal morphology in growing children with Pierre Robin sequence. Cleft Palate Craniofac J. 2012;49(5):553–560.

36.

Steinbacher

Bartlett

. Relation of the mandibular body and ramus in Treacher Collins syndrome. J Craniofac Surg. 2011;22(1):302–305.

37.

Suri

Ross

Tompson

. Craniofacial morphology and adolescent facial growth in Pierre Robin sequence. Am J Orthod Dentofac Orthop. 2010;137(6):763–774.

38.

Trainor

Dixon

. Treacher Collins syndrome: etiology, pathogenesis and prevention. Eur J Hum Genet. 2009;17(3):275–283.

39.

Travieso

Chang

Terner

Beckett

Wong

Teng

Derek

, et al. A range of condylar hypoplasia exists in Treacher Collins syndrome. J Oral Maxillofac Surg. 2013;71(2):393–397.

40.

Zellner

Reid

Steinbacher

. The Pierre robin mandible is hypoplastic and morphologically abnormal. J Craniofac Surg. 2017;28(8):1946–1949.

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