A Comparative Effectiveness Study of Speech and Surgical Outcomes: Study Overview

Mai CT Isenburg JL Canfield MA , et al. National population-based estimates for major birth defects, 2010–2014. Birth Defects Res. 2019;111(18):1420-1435. doi:https://doi.org/10.1002/bdr2.1589

Abbott MM Meara JG . Nasoalveolar molding in cleft care: Is it efficacious? Plast Reconstr Surg. 2012;130(3):659-666. doi:https://doi.org/10.1097/PRS.0b013e31825dc10a

Mink van der Molen AB van Breugel JM Janssen NG , et al. Clinical practice guidelines on the treatment of patients with cleft lip, alveolus, and palate: An executive summary. J Clin Med. 2021;10(21):4813. doi:https://doi.org/10.3390/jcm10214813

Roberts JM Jacobs A Marrow B Hauck R Samson TD . Current trends in unilateral cleft lip care: A 10-year update on practice patterns. Ann Plast Surg. 2020;84(5):595-601. doi:https://doi.org/10.1097/SAP.0000000000002017

Lane H Harding S Wren Y . A systematic review of early speech interventions for children with cleft palate. Int J Lang Commun Disord. 2022;57(1):226-245. doi:https://doi.org/10.1111/1460-6984.12683

Shaw WC Semb G Nelson P , et al. The Eurocleft project 1996-2000: Overview. J Craniomaxillofac Surg. 2001;29(3):131-140. doi:https://doi.org/10.1054/jcms.2001.0217

Sandy J Williams A Mildinhall S , et al. The Clinical Standards Advisory Group (CSAG) cleft lip and palate study. Br J Orthod. 1998;25(1):21-30. doi:https://doi.org/10.1093/ortho/25.1.21

Semb G Enemark H Friede H , et al. Scandcleft randomised trials of primary surgery for unilateral cleft lip and palate: 1. Planning and management. J Plast Surg Hand Surg. 2017;51(1):2-13. doi:https://doi.org/10.1080/2000656X.2016.1263202

Shaw W Semb G Lohmander A , et al. Timing of Primary Surgery for cleft palate (TOPS): Protocol for a randomised trial of palate surgery at 6 months versus 12 months of age. BMJ Open. 2019;9(7):e029780. doi:https://doi.org/10.1136/bmjopen-2019-029780

Long RE Hathaway R Daskalogiannakis J , et al. The Americleft study: An inter-center study of treatment outcomes for patients with unilateral cleft lip and palate part 1: Principles and study design. Cleft Palate Craniofac J. 2011;48(3):239-243. doi:https://doi.org/10.1597/09-180.1

Katzel EB Basile P Koltz PF Marcus JR Girotto JA . Current surgical practices in cleft care: Cleft palate repair techniques and postoperative care. Plast Reconstr Surg. 2009;124(3):899-906. doi:https://doi.org/10.1097/PRS.0b013e3181b03824

Kearney AM Gart MS Brandt KE Gosain AK . Lessons from American Board of Plastic Surgery Maintenance of Certification tracer data: A 16-year review of clinical practice patterns and evidence-based medicine in cleft palate repair. Plast Reconstr Surg. 2020;146(2):371-379. doi:https://doi.org/10.1097/PRS.0000000000007018

Timbang MR Gharb BB Rampazzo A Papay F Zins J Doumit G . A systematic review comparing Furlow double-opposing Z-plasty and straight-line intravelar veloplasty methods of cleft palate repair. Plast and Reconstr Surg. 2014;134(5):1014-1022. doi:https://doi.org/10.1097/PRS.0000000000000637

Williams WN Seagle MB Pegoraro-Krook MI , et al. Prospective clinical trial comparing outcome measures between Furlow and von Langenbeck palatoplasties for UCLP. Ann Plast Surg. 2011;66(2):154-163. doi:https://doi.org/10.1097/SAP.0b013e3181d60763

Furlow LT Jr . The Centrinho–UF study: Beyond the manuscript. Ann Plast Surg. 2011;67(3):320-321. doi:https://doi.org/10.1097/SAP.0b013e31822b8453

Li F Wang HT Chen YY , et al. Cleft relapse and oronasal fistula after Furlow palatoplasty in infants with cleft palate: Incidence and risk factors. Int J Oral Maxillofac Surg. 2016;46(3):275-280. doi:https://doi.org/10.1016/j.ijom.2016.09.019

Losken HW Van Aalst JA Teotia SS Dean SB Hultman S Uhrich KS . Achieving low cleft palate fistula rates: Surgical results and techniques. Cleft Palate Craniofac J. 2011;48(3):312-320. doi:https://doi.org/10.1597/08-288

Cohen S Kalinowski J LaRossa D Randall P . Cleft palate fistulas: A multivariate statistical analysis of prevalence, etiology, and surgical management. Plast Reconstr Surg. 1991;87(6):1041-1047.

Kara M Calis M Kara I Kulak Kayikci ME Gunaydin RO Ozgur F . Comparison of speech outcomes using type 2b intravelar veloplasty or Furlow double-opposing Z plasty for soft palate repair of patients with unilateral cleft lip and palate. J Cranio-Maxillofac Surg. 2021;49(3):215-222. doi:https://doi.org/10.1016/J.JCMS.2021.01.003

Sakran KA Liu R Yu T Al-Rokhami RK He D . A comparative study of three palatoplasty techniques in wide cleft palates. J Oral Maxillofac Surg. 2021;50:191-197. doi:https://doi.org/10.1016/j.ijom.2020.07.016

Zietsman MS Dibbs RP Davis MJ Volk AS Buchanan EP Monson LA . Furlow versus straight line repair with intravelar veloplasty: A 7-year single institution experience with fistula formation. Face. 2021;2(4):364-370. doi: https://doi.org/10.1177/27325016211056976

Stein MJ Zhang Z Fell M Mercer N Malic C Stein MJ . Determining postoperative outcomes after cleft palate repair: A systematic review and meta-analysis. J Plast Reconstr Aesthet Surg. 2018;72:85-91. doi:https://doi.org/10.1016/j.bjps.2018.08.019

Sackett DL Straus SE Richardson WS Rosenberg W Haynes RB . Evidence-based Medicine: How to Practice and Teach EBM. 2nd ed. Churchill Livingstone; 2000.

Balasubramanian SP Wiener M Alshameeri Z Tiruvoipati R Elbourne D Reed MW . Standards of reporting of randomized controlled trials in general surgery: Can we do better? Ann Surg. 2006;244(6):663-667. doi:https://doi.org/10.1097/01.sla.0000217640.11224.05

Hassanein AH Herrera FA Hassanein O . Challenges of randomized controlled trial design in plastic surgery. Canadian J Plast Surg. 2011;19(3):28-29. doi:https://doi.org/10.1177/229255031101900302

McLeod RS . Issues in surgical randomized controlled trials. World J Surg. 1999;23(12):1210-1214. doi:https://doi.org/10.1007/s002689900649

Thoma A Sprague S Temple C Archibald S . The role of the randomized controlled trial in plastic surgery. Clin Plast Surg. 2008;35(2):275-284. doi:https://doi.org/10.1016/j.cps.2007.10.011

Rothwell PM . External validity of randomised controlled trials: “To whom do the results of this trial apply?” Lancet. 2005;365(9453):82-93. doi:https://doi.org/10.1016/S0140-6736(04)17670-8

Benson K Hartz AJ . A comparison of observational studies and randomized, controlled trials. N Engl J Med. 2000;342(25):1878-1886. doi:https://doi.org/10.1056/NEJM200006223422506

Britton A McPherson K McKee M Sanderson C Black N Bain C . Choosing between randomised and non-randomised studies: A systematic review. Health Technol Asses. 1998;2(13;i-iv):1-124.

Concato J Shah N Horwitz RI . Randomized, controlled trials, observational studies, and the hierarchy of research designs. N Engl J Med. 2000;342(25):1887-1892. doi:https://doi.org/10.1056/NEJM200006223422507

Ioannidis JP Haidich AB Pappa M , et al. Comparison of evidence of treatment effects in randomized and nonrandomized studies. JAMA. 2001;286(7):821-830. doi:https://doi.org/10.1001/jama.286.7.821

Shikata S Nakayama T Noguchi Y Taji Y Yamagishi H . Comparison of effects in randomized controlled trials with observational studies in digestive surgery. Ann Surg. 2006;244(5):668-676. doi:https://doi.org/10.1097/01.sla.0000225356.04304.bc

Schaumberg DA McDonald L Shah S Stokes M Nordstrom BL Ramagopalan SV . Evaluation of comparative effectiveness research: A practical tool. J Comp Eff Res. 2018;7(5):503-515. doi: https://doi.org/10.2217/cer-2018-0007

Conway PH Clancy C . Comparative-effectiveness research — implications of the Federal Coordinating Council’s report. N Engl J Med. 2009;361(4):328-330. doi:https://doi.org/10.1056/NEJMP0905631

Horn SD Gassaway J . Practice based evidence: Incorporating clinical heterogeneity and patient-reported outcomes for comparative effectiveness research. Med Care. 2010;48(6):S17-S22. doi:https://doi.org/10.1097/MLR.0b013e3181d57473

Long RE Hathaway RR . Practice-based evidence from comparative effectiveness research to inform evidence-based practice. Cleft Palate Craniofac J. Published online August 30, 2023:10556656231198660. doi:https://doi.org/10.1177/10556656231198661

Sell D John A Harding-Bell A Sweeney T Hegarty F Freeman J . Cleft audit protocol for speech (CAPS-A) a comprehensive training package for speech analysis. Int J Lang Commun Disord. 2009;44(4):529-548.

John A Sell D Sweeney T Harding-Bell A Williams A . The cleft audit protocol for speech-augmented: A validated and reliable measure for auditing cleft speech. Cleft Palate Craniofac J. 2006;43(3):272-288. doi:https://doi.org/10.1597/04-141.1

Chapman KL Baylis A Trost-Cardamone J , et al. The Americleft Speech Project: A training and reliability study. Cleft Palate Craniofac J. 2016;53(1):93-108. doi:https://doi.org/10.1597/14-027

Van Eeden S . The relationship between auditory behaviours and speech and language development in children with cleft lip and palate. Curr Opin Otolaryngol Head Neck Surg. 2023;31(3):165-170. doi:https://doi.org/10.1097/MOO.0000000000000883

Persson C Niklasson L Óskarsdóttir S Johansson S Jönsson R Söderpalm E . Language skills in 5–8-year-old children with 22q11 deletion syndrome. Int J Lang Commun Disord. 2006;41(3):313-333. doi:https://doi.org/10.1080/13682820500361497

Scherer NJ D’Antonio LL Kalbfleisch JH . Early speech and language development in children with velocardiofacial syndrome. Am J Hum Genet. 1999;88(6):714-723. doi:https://doi.org/10.1002/(SICI)1096-8628(19991215)88:6 < 714::AID-AJMG24 > 3.0.CO2-B

Solot CB Gerdes M Kirschner RE , et al. Communication issues in 22q11.2 deletion syndrome: Children at risk. Genet Med. 2001;3(1):67-71. doi:https://doi.org/10.1097/00125817-200101000-00015

Solot CB Sell D Mayne A , et al. Speech-language disorders in 22q11.2 deletion syndrome: Best practices for diagnosis and management. Am J Speech Lang Pathol. 2019;28(3):984-999. doi:https://doi.org/10.1044/2019_AJSLP-16-0147

McCormack J McLeod S McAllister L Harrison LJ . A systematic review of the association between childhood speech impairment and participation across the lifespan. Int J Speech Lang Pathol. 2009;11(2):155-170. doi:https://doi.org/10.1080/17549500802676859

McCormack J McLeod S Harrison LJ McAllister L . The impact of speech impairment in early childhood: Investigating parents’ and speech-language pathologists’ perspectives using the ICF-CY. J Commun Disord. 2010;43(5):378-396. doi:https://doi.org/10.1016/j.jcomdis.2010.04.009

Thomas-Stonell N Oddson B Robertson B Rosenbaum P . Predicted and observed outcomes in preschool children following speech and language treatment: Parent and clinician perspectives. J Commun Disord. 2009;42(1):29-42. doi:https://doi.org/10.1016/j.jcomdis.2008.08.002

Chapman KL . The relationship between early reading skills and speech and language performance in young children with cleft lip and palate. Cleft Palate Craniofac J. 2011;48(3):301-311. doi:https://doi.org/10.1597/08-213

Hardin-Jones MA Chapman KL . Non-oral compensatory misarticulations revisited. Cleft Palate Craniofac J. 2022;59(8):976-983. doi:https://doi.org/10.1177/10556656211026488

Bishop DVM Adams C . A prospective study of the relationship between specific language impairment, phonological disorders and Reading retardation. J Child Psychol Psychiatr. 1990;31(7):1027-1050. doi:https://doi.org/10.1111/J.1469-7610.1990.TB00844.X

Britton L Albery L Bowden M Harding-Bell A Phippen G Sell D . A cross-sectional cohort study of speech in five-year-olds with cleft palate ± lip to support development of national audit standards: Benchmarking speech standards in the United Kingdom. Cleft Palate Craniofac J. 2014;51(4):431-451. doi:https://doi.org/10.1597/13-121

Stackhouse J Wells B . How do speech and language problems affect literacy development? In: Hulme C Snowling M , eds. Dyslexia: Biology, Cognition and Intervention. Singular Publishing Group; 1997:182-211.

Stothard SE Snowling MJ Bishop DVM Chipchase BB Kaplan CA . Language-impaired preschoolers. J Speech Lang Hear Res. 1998;41(2):407-418. doi:https://doi.org/10.1044/JSLHR.4102.407

Chapman KL Baylis AL Cordero K , et al. A multicenter comparison of speech outcomes: The Americleft Speech Project. Paper presented at: The European Cleft Palate Craniofacial Association Congress, June 12-15, 2019; Ultrecht, The Netherlands.

Goldman R Fristoe M . Goldman-Fristoe Test of Articulation, second edition. APA PsycTests; 2000. doi:https://doi.org/10.1037/t15098-000

Meinusch M Romonath R . Early language intervention for children with cleft lip and/or palate: A systematic review. Evid Based Commun Assess Interv. 2011;5(4):197-215. doi:https://doi.org/10.1080/17489539.2012.678093

Sand A Hagberg E Lohmander A . On the benefits of speech-language therapy for individuals born with cleft palate: A systematic review and meta-analysis of individual participant data. J Speech Lang Hear Res. 2022;65(2):555-573. doi:https://doi.org/10.1044/2021_JSLHR-21-00367

Law J Garrett Z Nye C . Speech and language therapy interventions for children with primary speech and language delay or disorder. Campbell Systematic Reviews. 2005;1(1):1-85. doi:https://doi.org/10.4073/csr.2005.5

Baylis A Dixon A Beckett L , et al. Speech therapy characteristics of 5-6 year-old children with cleft palate. Poster presented at: the 74th annual meeting of the American Cleft-Palate Craniofacial Association; March 13-18, 2017; Colorado Springs, CO.

Bessell A Sell D Whiting P , et al. Speech and language therapy interventions for children with cleft palate: A systematic review. Cleft Palate Craniofac J. 2013;50(1):1-17. doi:https://doi.org/10.1597/11-202

Hanley L Ballard KJ Dickson A Purcell A . Speech intervention for children with cleft palate using principles of motor learning. Am J Speech Lang Pathol. 2023;32(1):169-189. doi:https://doi.org/10.1044/2022_AJSLP-22-00007

Alighieri C Bettens K Perry J Hens G Roche N Van Lierde K . Achieving the next level in cleft speech intervention: A protocol of a randomized sham-controlled trial to provide guidelines for a personalized approach in children with cleft palate. Int J Lang Commun Disord. 2023;58(4):1405-1418. doi:https://doi.org/10.1111/1460-6984.12853

Alighieri C Bettens K Bruneel L Perry J Hens G Van Lierde K . One size doesn’t fit all: A pilot study toward performance-specific speech intervention in children with a cleft (lip and) palate. J Speech Lang Hear Res. 2022;65(2):469-486. doi:https://doi.org/10.1044/2021_JSLHR-21-00405

Alighieri C Van Lierde K De Caesemaeker AS , et al. Is high-intensity speech intervention better? A comparison of high-intensity intervention versus low-intensity intervention in children with a cleft palate. J Speech Lang Hear Res. 2021;64(9):3398-3415. doi:https://doi.org/10.1044/2021_JSLHR-21-00189

Alighieri C Bettens K Bruneel L D’haeseleer E Van Gaever E Van Lierde K . Effectiveness of speech intervention in patients with a cleft palate: Comparison of motor-phonetic versus linguistic-phonological speech approaches. J Speech Lang Hear Res. 2020;63(12):3909-3933. doi:https://doi.org/10.1044/2020_JSLHR-20-00129

Sweeney T Hegarty F Powell K Deasy L O’ Regan M Sell D . Randomized controlled trial comparing Parent Led Therapist Supervised Articulation Therapy (PLAT) with routine intervention for children with speech disorders associated with cleft palate. Int J Lang Commun Disord. 2020;55(5):639-660. doi:https://doi.org/10.1111/1460-6984.12542

Scherer NJ Yamashita R de Oliveira DN , et al. Early speech and language intervention in Brazilian-Portuguese toddlers with cleft lip and/or palate. Clin Linguist Phon. 2022;36(1):34-53. doi:https://doi.org/10.1080/02699206.2021.1912187

Morgan PL Hammer CS Farkas G , et al. Who receives speech/language services by 5 years of age in the United States? Am J Speech Lang Pathol. 2016;25(2):183-199. doi:https://doi.org/10.1044/2015_AJSLP-14-0201

Goldman R Fristoe M . Goldman-Fristoe Test of Articulation-3. Pearson; 2015.

Skirko JR Weaver EM Perkins JA Kinter S Eblen L Sie KC . Validity and responsiveness of VELO: A velopharyngeal insufficiency quality of life measure. Otolaryngol Head Neck Surg. 2013;149(2):304-311. doi:https://doi.org/10.1177/0194599813486081

McLeod S Harrison LJ McCormack J . The Intelligibility in Context Scale: Validity and reliability of a subjective rating measure. J Speech Lang Hear Res. 2012;55(2):648-656. doi:https://doi.org/10.1044/1092-4388(2011/10-0130)

Fenson L Marchman VA Thal DJ Dale PS Reznick JS Bates E . MacArthur-Bates Communicative Development Inventories. 2nd ed. Paul H. Brookes; 2007.

Squires J Bricker D . Ages & Stages Questionnaires, (ASQ-3). 3rd ed. Brookes; 2009.

Randall P LaRossa D McWilliams BJ Cohen M Solot C Jawad AF . Palatal length in cleft palate as a predictor of speech outcome. Plast Reconstr Surg. 2000;106(6):1254-1259. doi:https://doi.org/10.1097/00006534-200011000-00003

Harris PA Taylor R Thielke R Payne J Gonzalez N Conde JG . Research electronic data capture (REDCap)—A metadata-driven methodology and workflow process for providing translational research informatics support. J Biomed Inform. 2009;42(2):377-381. doi:https://doi.org/10.1016/J.JBI.2008.08.010

Harris PA Taylor R Minor BL , et al. The REDCap consortium: Building an international community of software platform partners. J Biomed Inform. 2019;95:103208. doi:https://doi.org/10.1016/J.JBI.2019.103208

Cummings C Sommer C Baylis A Pollard S Chapman K . Documenting the language environment diversity of infants and toddlers with cleft palate from Spanish-speaking families via a novel language questionnaire [236]. Cleft Palate Craniofac J. 2022;59(4S):97.

Gilkerson J Richards JA . The LENA^TM Developmental Snapshot: Technical Report No. LTR-07-2); 2008. https://www.lenafoundation.org/wp-content/uploads/2014/10/LTR-03-2_Audio_Specifications.pdf; 2008.

Cordero K Sommer C Cummings C , et al. The development, trialing, and adaptation of standard American English and Spanish phrases for assessing speech in preschoolers with cleft lip and palate [277]. Cleft Palate Craniofac J. 2022;59(45):114. doi:https://doi.org/10.1177/10556656221079212

Baylis AL Cummings CE Lien KM , et al. Standardization of videorecorded speech samples for children with cleft palate: Methods to facilitate high-quality speech outcomes data collection. Cleft Palate Craniofac J. Published online November 28, 2023. doi:https://doi.org/10.1177/10556656231217645

Cummings C Hardin-Jones M Baylis A , et al. Development of a novel data collection tool for early speech-language intervention in children with cleft palate [235]. Cleft Palate Craniofac J. 2022;59(4S):97. doi:https://doi.org/10.117/10556656221079212

Hardin-Jones M Heimbaugh L Chapman KL Baylis A Hatch Pollard S . Transcribing toddler vocalizations: Comparison of a modified naturalistic listening approach with phonetic transcription. Clin Linguist Phon. 2023;37(2):157-168. doi:https://doi.org/10.1016/j.jcomdis.2024.106417

Hardin-Jones M Chapman KL Heimbaugh L , et al. Stop consonant production in children with cleft palate after palatoplasty. Cleft Palate Craniofac J. 2023;61(7):1087-1095. doi:https://doi.org/10.1177/10556656231159974

Hardin-Jones MA Dahill AE Heimbaugh L Baylis A Cummings C Chapman KL . Correspondence between consonant inventories obtained using modified naturalistic listening in real time (NLRT) and parent report. J Commun Disord. 2024;108:106417. doi:https://doi.org/10.1016/j.jcomdis.2024.106417

Hardwiche JT Landini G Richard BM . Fistula incidence after primary cleft palate repair: A systematic review of the literature. Plast Reconstr Surg. 2014;134(4):618-627. doi:https://doi.org/10.1097/PRS.0000000000000548

The International Phonetic Alphabet (revised to 2015). Published 2015. Accessed November 26, 2023. https://www.internationalphoneticassociation.org/sites/default/files/IPA_Kiel_2015.pdf.

International Phonetic Association (IPA). The International Phonetic Alphabet (revised to 2015). Published 2015. Accessed April 4, 2023. https://www.internationalphoneticassociation.org/sites/default/files/IPA_Kiel_2015.pdf.

Cohen J . Statistical Power Analysis for the Behavioral Sciences. 2nd ed. Erlbaum; 1988.

Sitzman TJ Verhey EM Kirschner RE , et al. Cleft palate repair postoperative management: Current practices in the United States. Cleft Palate Craniofac J. 2022;61(5):827-833. doi:https://doi.org/10.1177/10556656221146891

Li L Green T Sauer B . Propensity score analysis with matching weight. In: Pan W Bai H , eds. Propensity Score Analysis: Fundamentals, Developments, and Extensions. Guilford Publications; 2015:141-167.

Khansa I Pollard SH Fogolin A , et al. Factors associated with delayed palatoplasty before, during, and after the COVID-19 pandemic. J Craniofac Surg. Published online February 27, 2024. doi:https://doi.org/10.1097/SCS.0000000000010065

Williams J Lien KM Kirschner R Alien G Chapman K . and on behalf of the Cleft Outcomes Research NETwork (CORNET) Consortium. Feeding management practices and timing of palate repair in infants with cleft palate with and without Pierre Robin Sequence: A multisite cross-sectional study. Cleft Palate Craniofac J. March 15, 2024. doi:10556656241239766

Baylis A Dixon A Kuric J , et al. Demographics of the typical cleft palate team patient: is the exception the new norm? Poster presented at: The 73rd Annual Meeting of the American Cleft Palate-Craniofacial Association; April 4-9, 2016; Atlanta, GA.

Sell D Mildinhall S Albery L Wills AK Sandy JR Ness AR . The cleft care UK study. Part 4: Perceptual speech outcomes. Orthod Craniofac Res. 2015;18:36-46. doi:https://doi.org/10.1111/ocr.12112

Sell D Grunwell P Mildinhall S , et al. Cleft lip and palate care in the United Kingdom—the clinical standards advisory group (CSAG) study. Part 3: Speech outcomes. Cleft Palate Craniofac J. 2001;38(1):30-37. doi:https://doi.org/10.1597/1545-1569_2001_038_0030_clapci_2.0.co_2

Willadsen E . Influence of timing of hard palate repair in a two-stage procedure on early speech development in Danish children with cleft palate. Cleft Palate Craniofac J. 2012;49(5):574-595.

Lohmander A Persson C Willadsen E , et al. Scandcleft randomised trials of primary surgery for unilateral cleft lip and palate: 4. Speech outcomes in 5-year-olds - velopharyngeal competency and hypernasality. J Plast Surg Hand Surg. 2017;51(1):27-37. doi:https://doi.org/10.1080/2000656x.2016.1254645

Willadsen E Lohmander A Persson C , et al. Scandcleft randomised trials of primary surgery for unilateral cleft lip and palate: 5. Speech outcomes in 5-year-olds - consonant proficiency and errors. J Plast Surg Hand Surg. 2017;51(1):38-51. doi:https://doi.org/10.1080/2000656X.2016.1254647

Radecki J Schonfeld RC . The impacts of COVID-19 on the research enterprise: A landscape review. Ithaka S + R; 2020. doi:https://doi.org/10.18665/SR.314247