The drug treatment of hypertension occurring during pregnancy is described. Diagnostic problems and management are outlined, and the available literature regarding the use of standard hypotensive agents in pregnancy is reviewed by drug class. Based on currently published literature and opinion, the following drugs are recommended when needed during pregnancy (with proper monitoring): methyldopa, hydralazine, and furosemide. Caution is recommended when the following drugs are used during pregnancy: propranolol, and thiazide diuretics. The following drugs are not recommended for use during pregnancy based on currently available information: reserpine, clonidine, chlorthalidone, prazosin, minoxidil, spironolactone, ethacrynic acid, metoprolol, nadolol, and guanethidine.
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