Trimethoprim/Sulfamethoxazole-Associated Pseudomembranous Colitis

Abstract

A case of TMP/SMX-associated pseudomembranous colitis is described in a patient being treated for a urinary tract infection. Pseudomembranes are visualized on proctosigmoidoscopy, and stool cultures identified Clostridium difficile as the causative organism. The patient was treated successfully with oral vancomycin. A review of this infrequently reported adverse reaction to TMP/SMX is presented, emphasizing etiology and treatment.

Keywords

antibiotic-associated pseudomembranous colitis trimethoprim-sulfamethoxazole adverse drug reaction vancomycin

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