Over-the-Counter Medications in Cardiac Transplant Recipients: Guidelines for Use

Gilbertson WE . The FDA's OTC drug review. In: Feldmann EG Blockstein WL Young LL McGinnis JV Meade VL Lawson LC , eds. Handbook of nonprescription drugs. 9th ed. Washington, DC: American Pharmaceutical Association, 1990: 25–40.

Sullivan AM . Jumping over the counter: Rx to OTC switch. Pharm Update 1990; 1 (16):1–13.

Soller RW . Outlook for OTC switches. Am Pharm 1991; NS31 (2):38–40.

Gumbleton M Brown JE Hawksworth G Whiting PH . The possible relationship between hepatic drug metabolism and ketoconazole enhancement of cyclosporine nephrotoxicity. Transplantation 1985; 40: 454–5.

White DJ Blatchford NR Canwenbergh G . Cyclosporine and ketoconazole. Transplantation 1984; 37: 214.

Kennedy MS Deeg MJ Siegel M Crowley JJ Storb R Thomas ED . Acute renal toxicity with combined use of amphotericin B and cyclosporine after marrow transplantation. Transplantation 1983; 35: 211–5.

Deray G Le Hoang P Aupetit B Achour A Rottembourg J Baumelou A . Enhancement of cyclosporine A nephrotoxicity by diclofenac. Clin Nephrol 1987; 27: 213–4.

Whiting PH Burke MD Thomson AW . Drug interactions with cyclosporine: Implications from animal studies. Transplant Proc 1986; 18 (suppl):56–70.

Lake KD . Management of drug interactions with cyclosporine. Pharmacotherapy 1991; 11 (suppl): 110–8S.

Lake KD . Cyclosporine drug interactions: A review. Cardiac Surg: State Art Rev 1988; 2 (4):617–30.

Yee GC . Pharmacokinetic interactions between cyclosporine and other drugs. Transplant Proc 1990; 22: 1203–7.

Yee GC McGuire TR . Pharmacokinetic interactions with cyclosporine. (Part I). Clin Pharmacokinet 1990; 19: 319–32.

Yee GC McGuire TR . Pharmacokinetic interactions with cyclosporine. (Part II). Clin Pharmacokinet 1990; 19: 400–15.

Baciewicz AM Baciewicz FA . Cyclosporine pharmacokinetic drug interactions. Am J Surg 1989; 157: 264–71.

Cockburn IT Krupp P . An appraisal of drug interactions with Sandimmune. Transplant Proc 1989; 21: 3845–50.

Brosen K . Recent developments in hepatic drug oxidation: Implications for clinical pharmacokinetics. Clin Pharmacokinet 1990; 18: 220–39.

Watkins PB . The role of cytochromes P450 in cyclosporine metabolism. J Am Acad Dermatol 1990; 23: 1301–11.

Kronbach T Fischer V Meyer LA . Cyclosporine metabolism in human liver: Identification of a cytochrome P-450III gene family as the major cyclosporine-metabolizing enzyme explains interactions of cyclosporine with other drugs. Clin Pharmacol Ther 1988; 43: 630–5.

Pichard P Fabre I Fabre G Domergue J Aubert Saint B Mourad G . Cyclosporin A drug interactions: Screening for inducers and inhibitors of cytochrome P450 (cyclosporin A oxidase) in primary cultures of human hepatocytes. Drug Metab Dispos 1990; 18: 595–606.

Venkat Raman G Sharman VL Lee HA . Azathioprine and allopurinol: A potentially dangerous combination. J Int Med 1990; 228: 69–71.

Dretchen KL Morgenroth VH III Standaert FG Walts LF . Azathioprine: Effects on neuromuscular transmission. Anesthesiology 1976; 45: 604–9.

Vetten KB . Immunosuppressive therapy and anesthesia. S Afr Med J 1973; 47: 767–70.

Buffington GA Dominguez JH Piering WF Hebert LA Kauffman HM Jr Lemann J Jr . Interaction of rifampin and glucocorticoids—adverse effect on renal allograft function. JAMA 1976; 236: 1958–60.

Jubiz W Meikle AW . Alterations of glucorticoid actions by other drugs and disease states. Drugs 1979; 18: 113–21.

Kozower M Veatch L Kaplan MM . Decreased clearance of prednisolone, a factor in the development of corticosteroid side effects. J Clin Endocrinol Metab 1974; 38: 407–12.

Laflin MJ . Interaction of pancuronium and corticosteroids. Anesthesiology 1977; 47: 471–2.

McAllister WA Thompson PJ Al-Habet SM Rogers HJ . Rifampicin reduces effectiveness and bioavailability of prednisolone. Br Med J 1983; 286: 923–5.

Wassner SJ Pennisi AJ Malekzadeh MH Fine RN . The adverse effect of anticonvulsant therapy on renal allograft survival. J Pediatr 1976; 88: 134–7.

Bolman RM Molina EJ Anderson R . Heart transplantation. In: Simmons RL Finch ME Ascher NL Najarian JS , eds. Manual of vascular access, organ donation, and transplantation. New York: Spring-Verlag, 1984; 215, 216, 218,222.

Pennock JL Oyer PE Reitz BA Jamieson SW Beiber CP Wallwork T . Cardiac transplantation in perspective for the future. Survival, complications, rehabilitation, and cost. J Thorac Cardiovasc Surg 1982; 83: 168–77.

Hallman GL Leatherman LL Leachman RD Rochelle DG Bricker DL Bloodwell RD . Function of the transplanted human heart. J Thorac Cardiovasc Surg 1969; 58: 318–25.

Stinson EB Griepp RB Schroeder JS Dong E Shumway NE . Hemodynamic observations one and two years after cardiac transplantation in man. Circulation 1972; 45: 1183–94.

Beck W Barnard CN Schrire V . Heart rate after cardiac transplantation. Circulation 1969; 40: 437–45.

Cannom DS Rider AK Stinson EB Harrison DC . Electrophysiologic studies in the denervated transplanted human heart, n. Response to norepinephrine, isoproterenol and propranolol. Am J Cardiol 1975; 36: 859–66.

Mohanty PK Thames MD Arrowood JA Sowers JR McNamara C Szentpetery S . Impairment of cardiopulmonary baroreflex after cardiac transplantation in humans. Circulation 1987; 75: 914–21.

Traill TA . Physiology and function of the transplant allograft. In: Baumgartner WA Reitz BA Achuff SC , eds. Heart and heart-lung transplantation. Philadelphia: WB Saunders, 1990: 266–78.

Qi AZ Tuna IC Gornick CC Barragry TP Blatchford JW Ring WS . Potentiation of cardiac electrophysiologic effects of verapamil after autonomic blockade or cardiac transplantation. Circulation 1987; 75: 888–93.

Bexton RS Hellestrand KJ Cory-Pearce R Spurrell RA English TA Camm AJ . The direct electrophysiologic effects of disopyramide phosphate in the transplanted human heart. Circulation 1983; 67: 38–45.

Mason JW Winkle RA Rider AK Stinson EB Harrison DC . The electrophysiologic effects of quinidine in the transplanted human heart. J Clin Invest 1977; 59: 481–9.

Hinrichsen H Halaebi A Kirch W . Hemodynamic effects of different H₂-receptor antagonists. Clin Pharmacol Ther 1990; 48: 302–8.

McInnes GT Brodie MJ . Drug interactions that matter: A critical appraisal. Drugs 1988; 36: 83–110.

Hansten PD Horn JR . In: Drug interactions. 6th ed. Lea & Febiger, 1989.

Jarowenko MV Van Buren CT Kramer WG Lorber MI Flechner SM Kahan BD . Ranitidine, cimetidine, and the cyclosporine-treated recipient. Transplantation 1986; 42: 311–2.

Hendricksson S Lindholm A . Inhibition of cyclosporin metabolism by other drugs in vitro. Transplant Proc 1988; 20: 569–71.

Henry DA MacDonald IA Kitchingman G Bell GD Langman MJ . Cimetidine and ranitidine: Comparison of effects on hepatic drug metabolism. Br Med J 1980; 281: 775–7.

D'Souza MJ Pollock SH Solomon HM . Cyclosporine-cimetidine interaction. Drug Metab Dispos 1988; 16: 57–9.

Jadoul M Hene RJ . Ranitidine and the cyclosporine-treated recipient (letter). Transplantation 1989; 48: 359.

Zazgornik J Schindler J Gremmel F Bakke P Kopsa H Derfler K . Ranitidine does not influence cyclosporine levels in renal transplant patients (abstract). Kidney Int 1985; 28: 401.

Humphries TJ . Famotidine: A noteable lack of drug interactions. Scand J Gastroenterol Suppl 1987; 134: 55–60.

Van der Meer JWM Keuning JJ Scheijgrond HW Heykants J Van Cutsem J Brugmans J . The influence of gastric acidity on the bioavailability of ketoconazole. J Antimicrob Chemother 1980; 6: 552–4.

Butman SM Wild JC Nolan PE Fagan TC Finley PR Hicks MJ . Prospective study of the safety and financial benefit of ketoconazole as adjunctive therapy to cyclosporine after heart transplantation. J Heart Lung Transplant 1991; 10: 351–8.

Baldessarini RJ . Drugs and the treatment of psychiatric disorders. In: Goodman AG Rail TW Nies AS Taylor P , eds. Goodman and Gilman's the pharmacological basis of therapeutics. 8th ed. New York: Pergamon Press, 1990: 383–435.

Hoffman BB Lefkowitz RJ . Catecholamines and sympathomimetic drugs. In: Gilman AG Rail TW Nies AS Taylor P , eds. Goodman and Gilman's the pharmacological basis of therapeutics. 8th ed. New York: Pergamon Press, 1990: 187–220.

Bryant BG Lombardi TP . Cold and allergy products. In: Feldmann EG Blockstein WL Young LL McGinnis JV Meade VL Lawson LC , eds. Handbook of nonprescription drugs. 9th ed. Washington, DC: American Pharmaceutical Association, 1990: 133–205.

Garrison JC . Histamine, bradykinin, and 5- hydroxytryptamine, and their antagonists. In: Gilman AG Rall TW Nies AS Taylor P , eds. Goodman and Gilman's the pharmacological basis of therapeutics. 8th ed. New York: Pergamon Press, 1990: 575–99.

Atkinson K Biggs JC Britton K Short R Mrongovius R Concannon A . Oral administration of cyclosporine A for recipients of allogeneic marrow transplants: Implications of clinical gut dysfunction. Br J Haematol 1984; 56: 223–31.

Paton DM Webster DR . Clinical pharmacokinetics of H,-receptor antagonists (the antihistamines). Clin Pharmacokinet 1985; 10: 477–97.

Simons FER Simons KJ . H,-receptor antagonist treatment of chronic rhinitis. J Allergy Clin Immunol 1988; 81: 975–80.

Maurer G Loosli HR Schreier E Keller B . Disposition of cyclosporine in several animal species and man. I. Structural elucidation of its metabolites. Drug Metab Dispos 1984; 12: 120–6.

Monahan BP Ferguson CL Killeavy ES Lloyd BK Troy J Cantilena LR Jr . Torsades de pointes occurring in association with terfenadine use. JAMA 1990; 264: 2788–90.

Jaffe JH Martin WR . Opioid analgesics and antagonists. In: Gilman AG Rall TW Nies AS Taylor P , eds. Goodman and Gilman's the pharmacological basis of therapeutics. 8th ed. New York: Pergamon Press, 1990: 485–521.

Van Tyle WK . Internal analgestic products. In: Feldmann EG Blockstein WL Young LL McGinnis JV Meade VL Lawson LC , eds. Handbook of nonprescription drugs. 9th ed. Washington, DC: American Pharmaceutical Association, 1990: 57–89.

Insel PA . Analgesic-antipyretics and antiinflammatory agents; drugs employed in the treatment of rheumatoid arthritis and gout. In: Gilman AG Rall TW Nies AS Taylor P , eds. Goodman and Gilman's the pharmacological basis of therapeutics. 8th ed. New York: Pergamon Press, 1990: 638–81.

Handschumacher RE . Immunosuppressive agents. In: Gilman AG Rall TW Nies AS Taylor P , eds. Goodman and Gilman's the pharmacological basis of therapeutics. 8th ed. New York: Pergamon Press, 1990: 1264–76.

Haynes RC Jr . Adrenocorticotropic hormone: Adrenocortical steroids and their synthetic analogs; inhibitors of the synthesis and actions of adrenocortical hormones. In: Gilman AG Rall TW Nies AS Taylor P , eds. Goodman and Gilman's the pharmacological basis of therapeutics. 8th ed. New York: Pergamon Press, 1990: 1431–62.

Levy RA Smith DL . Clinical difference among nonsteroidal antiinflammatory drugs: Implications for therapeutic substitution in ambulatory patients. DICP Ann Pharmacother 1989; 23: 76–85.

Bunning RD Barth WF . Sulindac, a potentially renal-sparing nonsteroidal anti-inflammatory drug. JAMA 1982; 248: 2864–7.

Sedor JR Williams SL Chremos AN Johnson CL Dunn MJ . Effects of sulindac and indomethacin on renal prostaglandin synthesis. Clin Pharmacol Ther 1984; 36: 85–91.

Sesin GP O'Keefe E Roberto P . Sulindac-induced elevation of serum cyclosporine concentration. Clin Pharm 1989; 8: 445–6.

Carmichael J Shankel SW . Effects of nonsteroidal anti-inflammatory drugs on prostaglandins and renal function. Am J Med 1985; 78: 992–1000.

Koch-Weser J . Acetaminophen. N Engl J Med 1976; 295: 1297–300.

Sandler DP Smith JC Weinberg CR Buckalew VM Jr Dennis VW Blythe WB . Analgesic use and chronic renal disease. N Engl J Med 1989; 320: 1238–43.

Brunton LL . Agents for control of gastric acidity and treatment of peptic ulcers. In: Gilman AG Rail TW Nies AS Taylor P , eds. Goodman and Gilman's the pharmacological basis of therapeutics. 8th ed. New York: Pergamon Press, 1990: 897–913.

Keown PA Stiller CR Sinclair NR Howson W Stawecki M McMichael J . The clinical relevance of cyclosporine blood levels as measured by radioimmunoassay. Transplant Proc 1983; 15: 2438–41.

Keogh A Day R Critchley L Duggin G Baron D . The effect of food and cholestyramine on the absorption of cyclosporine in cardiac transplant recipients. Transplant Proc 1988; 20: 27–30.

Ptachcinski R Venkataramanan R Rosenthal JT Burckart GJ Taylor RJ Hakala T . The effect of food on cyclosporine absorption. Transplantation 1985; 40: 174–6.

Gupta SK Benet LZ . Food increases the bioavailability of cyclosporine in healthy volunteers (abstract). Clin Pharmacol Ther 1989; 45: 148.

Garnett WR . Antacid products. In: Feldmann EG Blockstein WL Young LL McGinnis JV Meade VL Lawson LC , eds. Handbook of nonprescription drugs. 9th ed. Washington, DC: American Pharmaceutical Association, 1990: 243–92.

Uribe M Casian C Rojas S Sierra JG Go VL . Decreased bioavailability of prednisone due to antacids in patients with chronic active liver disease and in healthy volunteers. Gastroenterology 1981; 80: 661–5.

Tanner AR Caffin JA Halliday JW Powell LW . Concurrent administration of antacids and prednisone: Effect on serum levels of prednisolone. Br J Clin Pharmacol 1979; 7: 397–400.

Lee DAH Taylor GM Walker JG James VHT . The effect of concurrent administration of antacids on prednisolone absorption. Br J Clin Pharmacol 1979; 8: 92–4.

Bergrem H Djoseland O Jervell J Rugstad HE . Immunosuppressive treatment policies: A) absorption of prednisolone. I. The effect of fasting, food, and food combined with antacids. Scand J Urol Nephrol 1981; 64 (suppl):167–73.

US Department of Health and Human Services. The 1988 report of the Joint National Commission on Detection, Evaluation, and Treatment of High Blood Pressure. Bethesda, MD: Department of Health and Human Services, May 1988, 3, 12, 20; NIH publication no. 88–1088.

Bradley JG . Nonprescription drugs and hypertension: Which ones affect blood pressure. Post Grad Med 1991; 89: 195–202.

Longe RL . Antidiarrheal and other gastrointestinal products. In: Feldmann EG Blockstein WL Young LL McGinnis JV Meade VL Lawson LC , eds. Handbook of nonprescription drugs. 9th ed. Washington, DC: American Pharmaceutical Association, 1990: 313–31.

Brunton LL . Agents affecting gastrointestinal water flux and motility, digestants, and bile acids. In: Gilman AG Rall TW Nies AS Taylor P , eds. Goodman and Gilman's the pharmacological basis of therapeutics. 8th ed. New York: Pergamon Press, 1990: 914–32.

Portnoy BL Dupont HL Pruitt D Abdo JA Rodriguez JT . Antidiarrheal agents in the treatment of acute diarrhea in children. JAMA 1976; 236: 844–6.

Brown DD Juhl RP . Decreased bioavailability of digoxin due to antacids and kaolin-pectin. N Engl J Med 1976; 295: 1034–7.

Wagner JG . Pharmacokinetics. 1. Definitions, modeling and reasons for measuring blood levels and urinary excretion. Drug Intell Clin Pharm 1968; 2: 38–42.

Curry CE Tatum-Butler D . Laxative products. In: Feldman EG Blockstein WL Young LL McGinnis JV Meade VL Lawson LC , eds. Handbook of nonprescription drugs. 9th ed. Washington, DC: American Pharmaceutical Association, 1990: 343–64.

Brown DD Juhl RP . Altered bioavailability of digoxin produced by gastrointestinal medications (abstract). Clin Res 1979; 27: 610A.

Khalafallah N Gouda MW Khalil SA . Effect of surfactants on absorption through membranes. IV: Effects of dioctyl sodium sulfosuccinate on absorption of a poorly absorbable drug, phenolsulfonphthalein, in humans. J Pharm Sci 1975; 64: 991–4.

Tolman KG Hammar S Sannella JJ . Possible hepatotoxicity of doxidan. Ann Intern Med 1976; 84: 290–2.

Godfrey H . Dangers of dioctyl sodium sulfosuccinate in mixtures (letter). JAMA 1971; 215: 643.

Odera GM Korberly BH . Emetic and antiemetic products. In: Feldmann EG Blockstein WL Young LL McGinnis JV Meade VL Lawson LC , eds. Handbook of nonprescription drugs. 9th ed. Washington, DC: American Pharmaceutical Association, 1990: 293–312.

Caro JP Dombrowski SR . Sleep aid products. In: Feldmann EG Blockstein WL Young LL McGinnis JV Meade VL Lawson LC , eds. Handbook of nonprescription drugs. 9th ed. Washington, DC: American Pharmaceutical Association, 1990: 22641.

Rail TW . Drugs used in the treatment of asthma: The methylxanthines, cromolyn sodium, and other agents. In: Gilman AG Rall TW Nies AS Taylor P , eds. Goodman and Gilman's the pharmacological basis of therapeutics. 8th ed. New York: Pergamon Press, 1990: 618–37.