Abstract
OBJECTIVE:
To determine the effect of unit-of-use drug packaging of medications on compliance among elderly outpatients treated with complex medication regimens.
DESIGN:
Nonblind, randomized, clinical trial.
SETTING:
Geriatric outreach health centers in urban public housing units for independent-living elderly people.
PATIENTS:
Thirty-one patients (aged ≥60 y), each taking three or more prescribed medications. Patients were randomly assigned to one of three study groups: Group 1 (n=12), no change in dosing or packaging; group 2 (n=10), conventional packaging with twice-daily dosing; group 3 (n=9), unit-of-use packaging with twice-daily dosing.
INTERVENTION:
A unit-of-use package consisting of a two-ounce plastic cup with a snap-on lid containing all medications to be taken at the time of dosing.
MAIN OUTCOME MEASURES:
Medication compliance was assessed monthly for six months using tablet counts.
RESULTS:
Medication compliance was significantly better in group 3 (92.6 percent) using unit-of-use packaging compared with either group 1 (79 percent) or group 2 (82.6 percent) (p=0.017). Compliance did not differ between groups 1 and 2.
CONCLUSIONS:
In this small study of elderly outpatients taking three or more medications, unit-of-use packaging and twice-daily dosing improved medication compliance compared with conventional packaging.
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