We report a cytohistologic and immunohistochemical study of 2 cases of papillary thyroid carcinoma occurring in a thyroglossal duct cyst. The patients were a 21-yearold woman and a 48-year-old man. Needle aspiration cytology smears were consistent with papillary thyroid carcinoma. The Sistrunk procedure was done. Papillary carcinoma was found within a thyroglossal duct cyst. In 1 case, the tumor spread outside the cyst. Follow-up was uneventful in both patients (2 and 9 years, respectively). Our results would indicate that papillary carcinoma of thyroglossal duct cyst, though indistinguishable from its thyroid homologue, has a more indolent course and could therefore be singled out as a clinicopathologic entity. Needle aspiration cytology reliably assists in planning patient management.
1. Rosai J, Carcangiu ML, DeLellis R (eds): Atlas of tumor Pathology: Tumors of the thyroid gland. 3rd series, fascicle 5. Armed Forces Institute of Pathology, Washington, 1992
2.
2. LiVolsi VA. The thyroid and parathyroid. In Sternberg SS (ed): Diagnostic surgical pathology, 1st ed.Lippincott-Raven, New York, pp. 395-434, 1989
3.
3.Clemente CD (ed): Gray's anatomy of the human body, 30th ed.Lea and Febiger, Philadelphia, 1984
4.
4. Van Vuuren PA, Balm AJ, Gregor RT, et al. Carcinoma arising in thyroglossal remnants. Clin Otolaryngol19:509-515, 1994
5.
5. Tew S, Reeve TS, Poole AG, Delbridge L. Papillary carcinoma arising in thyroglossal duct cyst: Incidence and management. Aust N Z J Surg65:717-718, 1995
6.
6. Walton BR, Koch KE. Presentation and management of a thyroglossal duct cyst with a papillary carcinoma. South Med J90:758-761, 1997
7.
7. Urao M, Teitelbaum DH, Miyano T. Lingual thyroglossal duct cyst: A unique surgical approach. J Pediatr Surg31:1574-1576, 1996
8.
8. Maziak D, Borowy ZJ, Deitel M, Jacksic T, Edwards RA. Management of papillary carcinoma arising in thyroglossal-duct anlage. Can J Surg35:522-525, 1992
9.
9. Pitts WC, Tani EM, Skoog L. Papillary carcinoma in fine needle aspiration smears of a thyroglossal duct lesion (letter). Acta Cytol32:599-601, 1988
10.
10. Kashkari S. Identification of papillary carcinoma in a thyroglossal cyst by fine needle aspiration biopsy. Diagn Cytopathol6:267-270, 1990
12. Bardales RH, Suhrland MJ, Korourian S, Schaefer RF, Hanna EY, Stanley MW. Cytologic findings in thyroglossal duct carcinoma. Am J Clin Pathol106:615-619, 1996
13.
13. Nadji M, Morales AR. Immunoperoxidase techniques. In Silverberg SS (eds): Principles and practice of surgical pathology, 2nd ed.Churchill-Livingstone, New York, pp. 103-118, 1990
14.
14.Nadji M, Morales AR (eds): Immunoperoxidase techniques. A practical approach to tumor diagnosis, 1 st ed.ASCP Press, Chicago, 1984
15.
15. Strachan D, Wengraf C. An unusual thyroglossal cyst causing upper airway obstruction. Br J Clin Pract50:472-473, 1996
16.
16. Zidar N, Gale N, Podboj J. Unusual inflamed thyroglossal cyst. J Laryngol Otol109:899-890, 1995
17.
17. Roback SA, Telander RL. Thyroglossal duct cysts and branchial cleft anomalies. Semin Pediatr Surg3:142-146, 1994
18.
18. Katz AD, Hachigian M. Thyroglossal duct cyst. A thirty-year experience with emphasis on occurrence in older patients. Am J Surg155:741-744, 1988
19.
19. Weiss SD, Orlich CC. Primary papillary carcinoma of a thyroglossal duct cyst. Report of a case and literature review. Br J Surg78:87-89, 1991
20.
20. Khoo AK, Sittampalam K, Ooi LL. Primary papillary carcinoma in a thyroglossal cyst. A case report. Ann Acad Med Singapore22:606-608, 1993
21.
21. Martin-Perez M, Burguno-Garcia M, Echevarria-Iturbe C, Martinez-Perez D. Papillary carcinoma arising in a thyroglossal duct cyst. Report of a case. J Oral Maxillofac Surg51:89-93, 1993
23. Deshpande A, Bobhate SK. Squamous cell carcinoma in a thyroglossal duct cyst. J Laryngol Otol109:1001-1004, 1995
24.
24. Boswell WC, Zoller M, Williams JS, Lord SA, Check W. Thyroglossal duct carcinoma. Am Surg60:650-655, 1994
25.
25. Woods RH, Saunders JR Jr, Pearlman S, Hirata RM, Jaques DA. Anaplastic carcinoma arising in a thyroglossal duct tract. Otolaryngol Head Neck Surg109:945-949, 1993
26.
26. Cote DN, Sturgis EM, Peterson T, Miller RH. Thyroglossal duct cyst carcinoma. An unusual case of Hurthle cell carcinoma. Otolaryngol Head Neck Surg113:153-156, 1995
27.
27. Chang T-J, Chang T-C, Hsiao Y-L. Fine needle aspiration cytology of thyroglossal duct cyst. An analysis of 10 cases (letter). Acta Cytol43:321-322, 1999
