Cathepsin D (CatD) and tenascin C (Tn-C) have been implicated in invasion and metastasis of carcinomas. However, little is known about CatD and Tn-C distribution in mesenchymal tumors. Therefore, we aimed to investigate the expression of Tn-C and CatD in adipocytic tumors. Tn-C and CatD expressions in 27 lipomas, 5 atypical lipomatous tumor/well-differentiated liposarcomas (ALT/WDLS) and 11 liposarcomas (LS) were evaluated by immunohistochemistry and scored semiquantitatively. CatD expression was higher in ALT/WDLS than in lipomas (p<0.001), and higher in LS than in ALT/WDLS (p=0.009). Stromal Tn-C expression was higher in ALT/WDLS than in lipomas (p=0.02), but no difference was observed between ALT/WDLS and LS (p>0.05). These results indicate that Tn-C and CatD may be markers of locally aggressive or malignant behavior in adipocytic tumors.
1. Emoto K, Yamada Y, Sawada H, et al. Annexin II overexpression correlates with stromal Tenascin-C overexpression. A prognostic marker in colorectal carcinoma. Cancer92:1419-1426, 2001
2.
2. Jones PL, Jones FS. Tenascin-C in development and disease: Gene regulation and cell function. Matrix Biol19:581-596, 2000
3.
3. Rochefort H, Liaudet-Coopman E. Cathepsin D in cancer metastasis: A protease and a ligand. APMIS107:86-95, 1999
4.
4. Baekelandt M, Holm R, Trope CG, et al. The significance of metastasis-related factors cathepsin-D and nm23 in advanced ovarian cancer. Ann Oncol10:1335-1341, 1999
5.
5. Falcon O, Chirino R, Leon L, et al. Low levels of cathepsin D are associated with a poor prognosis in endometrial cancer. Br J Cancer79:570-576, 1999
6.
6. Goussia A, loachim E, Peschos D, et al. Immunohistochemical expression of cathepsin D in laryngeal epithelial lesions: Correlation with CD44 expression, p53, and Rb status, and proliferation-associated indices. Anticancer Res19:3055-3060, 1999
7.
7. Stehle G, Wunder A, Hartung G, Sinn H, Heene DL. Prognostic value of cathepsin D in breast cancer. Br J Cancer81:1426-1428, 1999
8.
8. Foekens JA, Look MP, Vries JB, et al. Cathepsin D in primary breast cancer: Prognostic evaluation involving 2,810 patients. Br J Cancer79:300-307, 1999
9.
9. Lah TT, Cercek M, Blejec A, et al. Cathepsin B, a prognostic indicator in lymph node-negative breast carcinoma patients: Comparison with cathepsin D, cathepsin L, and other clinical indicators. Clin Cancer Res6:578-584, 2000
10.
10. Thewes M, Engst R, Boeck K, Ring J. Expression of cathepsins in dermal fibrous tumors: An immunohistochemical study. Eur J Dermatol8:86-89, 1998
11.
11. Golaszewski Z, Sobolewski K, Golaszewska J, et al. Activity of lysosomal and nonlysosomal proteases of fibrosarcoma induced by methylcholanthrene. Rocz Akad Med Bialymst42:213-217, 1997
12.
12. Schnyder B, Semadeni RO, Fischer RW, et al. Distribution pattern of tenascin-C in normal and neoplastic mesenchymal tissues. Int J Cancer72:217-224, 1997
13.
13. Kahn HJ, Fekete E, From L. Tenascin differentiates dermatofibroma from dermatofibrosarcoma protuberans: Comparison with CD34 and Factor XIIIa. Hum Pathol32:50-56, 2001
14.
14. Fletcher C, Unni KK, Mertens F (eds). World Health Classification of tumors. Pathology & genetics of tumors of soft tissue and bone. IARCPress, Lyon, France, pp. 19-46, 2002
15.
15. Guillou L, Coindre JM, Bonichon F, et al. Comparative study of the National Cancer Institute and French Federation of Cancer Centers. Sarcoma group grading systems in a population of 410 adult patients with soft tissue sarcoma. J Clin Oncol15:350-362, 1997
16.
16. Mayer A, Fritz E, Fortelny R, Kofler K, Ludwig H. Immunohistochemical evaluation of cathepsin D expresion in colorectal cancer. Cancer Invest15:106-110, 1997
17.
17. Wurl P, Taubert H, Meye A, et al. Immunohistochemical and clinical evaluation of cathepsin expression in soft tissue sarcomas. Virchows Arch430:221-225, 1997
18.
18. Juhasz A, Bardos H, Repassy G, Adany R. Characteristic distribution patterns of tenascin in laryngeal and hypopharyngeal cancers. Laryngoscope110:84-92, 2000
19.
19. Jahkola T, Toivonen T, Virtanen I, et al. Tenascin-C expression in invasion border of early breast cancer: A predictor of local and distant recurrence. Br J Cancer78:1507-1513, 1998
20.
20. Yoshida T, Yoshimura E, Numata H, et al. Involvement of tenascin-C in proliferation and migration of laryngeal carcinoma cells. Virchows Arch435:496-500, 1999
21.
21. Franchi A, Santucci M. Tenascin expression in cutaneous fibrohistiocytic tumors. Am J Dermatopathol18:454-459, 1996
