Hodgkin's lymphoma almost always presents with lymphadenopathy. Presentation with extranodal disease is quite unusual, although Hodgkin's lymphoma is known to occasionally involve extranodal sites. However, no well-documented cases of testicular Hodgkin's lymphoma have been described. We report the case of a 52-year-old man who presented with a left testicular mass; orchiectomy revealed morphologic and immunophenotypic features typical of classical Hodgkin's lymphoma, nodular sclerosis type.
Darby S., Hancock BWLocalised non-Hodgkin lymphoma of the testis: the Sheffield Lymphoma Group experience. Int J Oncol.2005;26:1093-1099.
2.
Ferry JA, Harris NL, Young RH, Coen J., Zietman A., Scully REMalignant lymphoma of the testis, epididymis, and spermatic cord. A clinicopathologic study of 69 cases with immunophenotypic analysis. Am J Surg Pathol. 1994;18:376-390.
3.
Ferry J., Young R.Malignant lymphoma of the genitourinary tract. Curr Diagn Pathol.1997;4:145-169.
4.
Fonseca R., Habermann T., Colgan J., et al. Testicular lymphoma is associated with a high incidence of extranodal recurrence. Cancer. 2000;88:154-161.
5.
Hasselblom S. , Ridell B., Wedel H., Norrby K., Sender Baum M., Ekman T.Testicular lymphoma—a retrospective, population-based, clinical and immunohistochemical study. Acta Oncol.2004;43:758-765.
6.
Pectasides D. , Economopoulos T., Kouvatseas G., et al. Anthracycline-based chemotherapy of primary non-Hodgkin's lymphoma of the testis: The Hellenic Cooperative Oncology Group experience. Oncology. 2000;58: 286-292.
7.
Zucca E., Conconi A., Mughal TI, et al. Patterns of outcome and prognostic factors in primary large-cell lymphoma of the testis in a survey by the International Extranodal Lymphoma Study Group. J Clin Oncol.2003; 21:20-27.
8.
Shahab N., Doll D.Testicular lymphoma. Sem Oncol.1999;26:259-269.
9.
Ulbright T., Amin M., Young R.Tumors of the Testis, Adnexa, Spermatic Cord and Scrotum. Washington, DC: Armed Forces Institute of Pathology ; 1999:385.
10.
Touroutoglou N., Dimopoulos MA, Younes A., et al. Testicular lymphoma: late relapses and poor outcome despite doxorubicin-based therapy. J Clin Oncol.1995; 13:1361-1367.
11.
Berkman N., Breuer R., Kramer M., Polliack A.Pulmonary involvement in lymphoma. Leuk Lymphoma.1996;20: 229-237.
12.
Costa MB, Siqueira SA, Saldiva PH, Rabe KF, Mauad T.Histologic patterns of lung infiltration of B-cell, T-cell, and Hodgkin lymphomas . Am J Clin Pathol.2004;121: 718-726.
13.
Kapadia SB, Roman LN, Kingma DW, Jaffe ES, Frizzera G.Hodgkin's disease of Waldeyer's ring. Clinical and histoimmunophenotypic findings and association with Epstein-Barr virus in 16 cases. Am J Surg Pathol. 1995;19:1431-1439.
14.
Quinones-Avila Mdel P., Gonzalez-Longoria AA, Admirand JH, Medeiros LJHodgkin lymphoma involving Waldeyer ring: a clinicopathologic study of 22 cases. Am J Clin Pathol.2005;123:651-656.
15.
Dargent J., DeWolf-Peeters C. Liver involvement by lymphoma: Identification of a distinctive pattern of infiltration related to T-cell/histiocyte-rich B-cell lymphoma . Ann Diagn Pathol. 1998;2:363-369.
16.
Kumar S., Fend F., Quintanilla-Martinez L., et al. Epstein-Barr virus positive primary gastrointestinal Hodgkin's disease: Association with inflammatory bowel disease and immunosuppression . Am J Surg Pathol. 2000;24:66-73.
17.
Kelly MD, Stuart M., Tschuchnigg M., Turner J., Tydd T.Primary intestinal Hodgkin's disease complicating ileal Chrohn's disease. Aust N Z J Surg.1997;67:485-489.
18.
Li S., Borowitz M.Primary Epstein-Barr virus-associated Hodgkin's disease of the ileum complicating Crohn disease. Arch Pathol Lab Med.2001;125:424-427.
19.
Venizelos I. , Tamiolakis D., Bolioti S., et al. Primary gastric Hodgkin's lymphoma: a case report and review of the literature. Leuk Lymphoma.2005;46:147-150.
20.
Gebert C., Hardes J., Ahrens H., Buerger H., Winkelmann W., Gosheger G.Primary multifocal osseous Hodgkin disease: a case report and review of the literature. J Cancer Res Clin Oncol.2005;131:163-168.
21.
Habermann T. , Ryu J., Inwards J., Kurtin P.Primary pulmonary lymphoma. Sem Oncol.1999;26:307-315.
22.
Vishniavsky S.Hodgkin's sarcoma involving the testicle and adnexa. Va MedMon. 1973;100:534-537.
23.
Glaholm J., Brada M., Horwich A.Hodgkin's disease of the epididymis and testis. J R Soc Med.1989;82:558-559.
24.
Ingram R., Williams M., Fintel W., Ross M.Testicular lymphoma: A literature review and report of a case with a zoster-like cutaneous recurrence. Clin Lymphoma.2002; 2:238-241.
25.
Couper G., Anderson DN, Youngson GGBurkitt's tumour of the testicle: an unusual presentation of a lymphomatous process in childhood. Br J Urol.1994;74:124-125.
26.
Heller KN, Teruya-Feldstein J, LaQuaglia MP, Wexler LH. Primary follicular lymphoma of the testis: excellent outcome following surgical resection without adjuvant chemotherapy. J Pediatr Hematol Oncol.2004;26:104-107.
27.
Finn L., Viswanatha D., Belasco J., et al. Primary follicular lymphoma of the testis in childhood. Cancer. 1999; 85:1626-1635.
28.
Moertel CL, Watterson J., McCormick SR, Simonton SCFollicular large cell lymphoma of the testis in a child. Cancer. 1995; 75:1182-1186.
29.
Talerman A.Primary malignant lymphoma of the testis associated with sclerosis and nodularity. Br J Urol.1977; 49:23-28.
30.
Pakzad K., MacLennan GT, Elder JS, et al. Follicular large cell lymphoma localized to the testis in children . J Urol.2002;168:225-228.
31.
Akhtar M., Al-Dayel F., Siegrist K., Ezzat A.Neutrophil-rich Ki-1-positive anaplastic large cell lymphoma presenting as a testicular mass. Mod Pathol. 1996;9:812-815.
32.
Azua-Romeo J., Alvarez-Alegret R., Serrano P., Mayayo E.Primary anaplastic large cell lymphoma of the testis. Int Urol Nephrol.2004;36:393-396.
33.
Wilkins BS, Williamson JM, O'Brien CJMorphological and immunohistochemical study of testicular lymphomas. Histopathology.1989;15:147-156.
34.
Chan Jkc, Tsang Wyw, Lau WH, et al. Aggressive T/ natural killer cell lymphoma presenting as testicular tumor. Cancer. 1996;77:1198-1205.
35.
Chan J., Sin V., Wong K., et al. Nonnasal lymphoma expressing the natural killer cell marker CD56: a clinicopathologic study of 49 cases of an uncommon aggressive neoplasm . Blood. 1997;89:4501-4513.
36.
Ballereau C. , Leroy X., Morschhauser F., et al. Testicular natural killer T-cell lymphoma . Int J Urol.2005; 12: 223-224.
37.
Kim Y., Chang S., Yang W-I., et al. Primary NK/T cell lymphoma of the testis. Acta Haematol.2003;109:95-100.
38.
Dalle J., Mechinaud F., Michon J., et al. Testicular disease in childhood B-cell Non-Hodgkin's lymphoma: the French Society of Pediatric Oncology experience. J Clin Oncol.2001;19:2397-2403.
39.
Reid H., Marsden H.Gonadal infiltration in children with leukemia and lymphoma. J Clin Pathol.1980;33: 722-729.