Hybrid Verrucous—Squamous Cell Carcinoma of the Ovary With Synchronous Squamous Cell Carcinoma of the Endometrium

Abstract

Verrucous carcinoma, a variant of well-differentiated squamous cell carcinoma, is usually described in the literature as arising in the oral cavity, skin, and larynx. The reports on verrucous carcinoma arising in the genital tract, usually originating in the vagina, vulva, or uterine cervix, are few. Verrucous carcinoma arising in the ovary has not been previously reported. In this article, a unique hybrid carcinoma, a large aggressive verrucous carcinoma in combination with squamous carcinoma of the left ovary and synchronously occurring with a squamous cell carcinoma in the endometrium, is presented. This unique case of a hybrid carcinoma includes the first-known case of this type of carcinoma involving the ovary. The negative cervical evaluation findings, together with the histologic patterns of the tumors in the uterus and the ovary, support the conclusion that these 2 carcinomas are synchronous, one arising in the left ovary and the other arising in the uterus.

Keywords

hybrid carcinoma verrucous carcinoma ovary uterus squamous carcinoma endometrium synchronous

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References

Johnson D. , Lo R. , Srighley J. , Ayala A. Verrucous carcinoma of the penis. J Urol. 1985;133:216-218.

Illanes D. , Broman J. , Meyer B. , Kredenster D. , McElrath T. , Timmins P. Verrucous carcinoma of the endometrium: case history, pathologic findings, brief review of literature and discussion. Gynecol Oncol. 2006;102:375-377.

Shidara Y. , Karube A. , Watanabe M. , et al. A case report: verrucous carcinoma of the endometrium—the difficulty in diagnosis, and a review of the literature. J Obstet Gynaecol Res. 2000;26:189-192.

Ryder D. Verrucous carcinoma of the endometrium—a unique neoplasm with long survival . Obstet Gynecol. 1982;59:78S-80S.

Szcezepulska E. , Nasierowska-Guttmejer A. , Bidzinski M.

Cervical verrucous carcinoma involving endometrium, case report. Eur J

Gynecol Oncol. 1999;20:35-37.

Razquin S. , Mayayo E. , Anton E. , Alvira R. Squamous cell carcinoma in situ of the endometrium as superficial extension of cervical carcinoma. Gynecol Obstet Invest. 1993;35:190-192.

Kanbour A. , Stock R. Squamous cell carcinoma in situ of the endometrium and fallopian tube as superficial extension of invasive cervical carcinoma. Cancer. 1978;42:570-580.

Mai K. , Yazdi H. , Bertrand M. , Le Saus N. , Cathcard L. Bilateral primary ovarian squamous cell carcinoma associated with human papilloma virus infection and vulvar and cervical intraepithelial neoplasia. A case report with review of the literature. Am Surg Pathol. 1996; 20:767-772.

Pins M. , Young R. , Crum C. , Leach I. , Scully R. Cervical squamous cell carcinoma in situ with intraepithelial extension to the upper genital tract and invasion of tubes and ovaries; report of a case of human papilloma virus analysis. In J Gynecol Pathol. 1997;16:272-278.

10.

Manolitsas T. , Lanham S. , Hitchcock A. , Watson R. Synchronous ovarian and cervical squamous intraepithelial neoplasia: an analysis of HPV status. Gynecol Oncol. 1998;70:428-431.

11.

McGrady B. , Sloan J. , Lamki H. , Fox H. Bilateral ovarian cysts with squamous intraepithelial neoplasia. Int J Gynecol Pathol. 1993;12:350-354.

12.

Pins M. , Young R. , Daly W. , Scully R. Primary squamous cell carcinoma of the ovary. Report of 37 cases. Am J Sur Pathol. 1996;20:823-833.