Geographical differences have been shown in the clinical outcomes of Helicobacter pylori—associated gastritis phenotypes and in gastric cancer risk. This study tested whether the Operative Link on Gastritis Assessment (OLGA) staging correlated with gastric cancer risk in populations from 3 continents. Mapped gastric biopsies were obtained from 316 dyspeptic adults aged less than 41 years from 8 geographic areas that differed in gastric cancer risk. Gastric atrophy was assessed according to internationally validated criteria. Gastritis stage was established according to the OLGA staging system. The most prevalent gastritis stages were 0 to II, which included all subjects entered from Chile, Germany, India, Italy, and Thailand. Gastritis Stages III and IV were limited to the Chinese and Korean populations. Indians had a high prevalence of H pylori infection without high-stage gastritis. In populations at different cancer risk, the gastritis OLGA stage mirrored the gastric cancer incidence. Gastritis staging identifies a subgroup of higher-risk patients.
Correa P.Chronic gastritis: a clinico-pathological classification. Am J Gastroenterol. 1988;83:504-509.
2.
Owen DAGastritis and carditis. Mod Pathol. 2003;16: 325-341.
3.
Forman D., Sitas F., Newell DG, et al. Geographic association of Helicobacter pylori antibody prevalence and gastric cancer mortality in rural China. Int J Cancer . 1990;46:608-611.
4.
Genta RM, Gurer IE, Graham DYGeographical pathology of Helicobacter pylori infection: is there more than one gastritis? Ann Med. 1995;27:595-599.
5.
Graham DYHelicobacter pylori infection in the pathogenesis of duodenal ulcer and gastric cancer: a model. Gastroenterology. 1997;113:1983-1991.
6.
Correa P.The biological model of gastric carcinogenesis. IARC Sci Publ . 2004;301-310.
7.
Uemura N., Okamoto S., Yamamoto S., et al. Helicobacter pylori infection and the development of gastric cancer. N Engl J Med. 2001;345:784-789.
8.
Filipe MI, Munoz N., Matko I., et al. Intestinal metaplasia types and the risk of gastric cancer: a cohort study in Slovenia. Int J Cancer. 1994;57:324-329.
9.
Sipponen P., Kekki M., Haapakoski J., Ihamäki T., Siurala M.Gastric cancer risk in chronic atrophic gastritis: statistical calculations of cross-sectional data. Int J Cancer. 1985 ;35:173-177.
10.
Sipponen P. , Stolte M.Clinical impact of routine biopsies of the gastric antrum and body. Endoscopy. 1997;29: 671-678.
11.
Dixon MF, Genta RM, Yardley JH, Correa P.Classification and grading of gastritis. The updated Sydney System . International Workshop on the Histopathology of Gastritis, Houston1994. Am J Surg Pathol. 1996;20: 1161-1181.
12.
Rugge M., Correa P., Dixon MF, et al. Gastric mucosal atrophy: interobserver consistency using new criteria for classification and grading. Aliment Pharmacol Ther. 2002;16:1249-1259.
13.
Stolte M., Meining A.Helicobacter pylori gastritis of the gastric carcinoma phenotype: is histology capable of identifying high-risk gastritis?J Gastroenterol . 2000; 35(suppl 12): 98-101.
14.
Rugge M., Genta RMStaging and grading of chronic gastritis. Hum Pathol . 2005;36:228-233.
15.
Olga Group .Staging gastritis: an international proposal . Gastroenterology. 2005;129: 1807-1808.
16.
El-Zimaity HM, Graham DYEvaluation of gastric mucosal biopsy site and number for identification of Helicobacter pylori or intestinal metaplasia: role of the Sydney System. Hum Pathol. 1999 ;30:72-77.
17.
Genta RMRecognizing atrophy: another step toward a classification of gastritis . Am J Surg Pathol. 1996; 20(suppl 1):S23-S30.
18.
Crew KD, Neugut AIEpidemiology of gastric cancer. World J Gastroenterol . 2006;12:354-362.
19.
Parkin DM, Whelan SL, Ferlay J.Cancer Incidence in Five Continents. Lyon, France: International Agency for Research on Cancer; 1997.
20.
Cassaro M., Rugge M., Gutierrez O., Leandro G., Graham DY, Genta RMTopographic patterns of intestinal metaplasia and gastric cancer. Am J Gastroenterol. 2000;95:1431-1438.
21.
Rugge M., Leandro G., Farinati F., et al. Gastric epithelial dysplasia. How clinicopathologic background relates to management. Cancer. 1995;76:376-382.
22.
Nervi G., Liatopoulou S., Cavallaro LG, et al. Does Helicobacter pylori infection eradication modify peptic ulcer prevalence? A 10 years' endoscopical survey. World J Gastroenterol. 2006;12:2398-2401.
23.
El-Zimaity HMT , Gutierrez O., Kim JG, et al. Geographic differences in the distribution of intestinal metaplasia in duodenal ulcer patients. Am J Gastroenterol. 2001;96:666-672.
24.
Hu PJ, Li YY, Lin HL, et al. Gastric atrophy and regional variation in upper gastrointestinal disease. Am J Gastroenterol. 1995;90:1102-1106.
25.
Kamada T., Sugiu K., Hata J., et al. Evaluation of endoscopic and histological findings in Helicobacter pylori-positive Japanese young adults. J Gastroenterol Hepatol . 2006;21:258-261.
26.
El-Omar EM, Carrington M., Chow WH, et al. The role of interleukin-1 polymorphisms in the pathogenesis of gastric cancer. Nature. 2001;412:99.
27.
El-Omar EM, Rabkin CS, Gammon MD, et al. Increased risk of noncardia gastric cancer associated with proinflammatory cytokine gene polymorphisms. Gastroenterology. 2003;124:1193-1201.
28.
Fei SJ, Xiao SDDiet and gastric cancer: a case-control study in Shanghai urban districts . Chin J Dig Dis. 2006; 7:83-88.
29.
Hou L., El-Omar EM, Chen J., et al. Polymorphisms in Th1-type cell-mediated response genes and risk of gastric cancer. Carcinogenesis. 2007;28:118-123.
30.
Nouraie M., Pietinen P., Kamangar F., et al. Fruits, vegetables, and antioxidants and risk of gastric cancer among male smokers. Cancer Epidemiol Biomarkers Prev. 2005;14:2087-2092.
31.
Rugge M., Busatto G., Cassaro M., et al. Patients younger than 40 years with gastric carcinoma: Helicobacter pylori genotype and associated gastritis phenotype. Cancer . 1999; 85:2506-2511.
