Basal cell carcinoma (BCC) of the oral cavity is a controversial lesion with clinical and histopathologic features that overlap with those of peripheral ameloblastoma (PA). Ber-EP4, a cell surface glycoprotein preferentially expressed in BCC of the skin, has been suggested as a useful marker to support the diagnosis of oral BCC.This study presents a case of intraoral BCC arising in the anterior buccal mucosa of a patient with nevoid basal cell carcinoma syndrome (NBCCS), which represents a previously unreported clinical finding, to our knowledge. Histopathologic and immunohistochemical features of the case were compared to examples of PA, conventional intraosseous ameloblastoma, sporadic cutaneous BCC and cutaneous BCC from NBCCS patients. Ber-EP4 expression by the oral tumor was distinct from both peripheral and intraosseous forms of ameloblastoma and was identical to cutaneous BCC in both sporadic and syndromic settings.
Greer RO Jr , Hammond WSExtraosseous ameloblastoma: light microscopic and ultrastructural observations. J Oral Surg. 1978;36:553-556.
3.
Patrikiou A. , Papanicolaou S., Stylogianni E., Sotiriadou S.Peripheral ameloblastoma. Case report and review of the literature. Int J Oral Surg.1983;12:51-55.
4.
Simpson HEBasal-cell carcinoma and peripheral ameloblastoma. Oral Surg Oral Med Oral Pathol. 1974; 38:233-240.
5.
Gardner DGPeripheral ameloblastoma: a study of 21 cases, including 5 reported as basal cell carcinoma of the gingiva. Cancer. 1977 ;39:1625-1633.
6.
Woo SB, Smith-Williams JE, Sciubba JJ, Lipper S.Peripheral ameloblastoma of the buccal mucosa: case report and review of the English literature. Oral Surg Oral Med Oral Pathol. 1987;63:78-84.
7.
Welton DG, Elliot JA, Kimmelstiel P.Epithelioma: clinical and histologic data on 1,025 lesions. Arch Dermatol. 1949;60: 277-293.
8.
Keen RR, Elzay RPBasal cell carcinoma from mucosal surface of lower lip: report of a case. J Oral Surg Anesth Hosp Dent Serv. 1964;22:453-455.
Del Rosario RN, Barr RJ, Jensen JL, Cantos KABasal cell carcinoma of the buccal mucosa . Am J Dermatopathol. 2001;23:203-205.
12.
Braunstein E.Case report of an extraosseous adamantinoblastoma . Oral Surg Oral Med Oral Pathol. 1949;2: 726-728.
13.
Klinar KL, McManis JCSoft-tissue ameloblastoma. Report of a case. Oral Surg Oral Med Oral Pathol. 1969;28: 266-272.
14.
Latza U., Niedobitek G., Schwarting R., Nekarda H., Stein H.Ber-EP4: new monoclonal antibody which distinguishes epithelia from mesothelial . J Clin Pathol. 1990;43: 213-219.
15.
Jimenez FJ, Burchette JL Jr, Grichnik JM, Hitchcock MGBer-EP4 immunoreactivity in normal skin and cutaneous neoplasms. Mod Pathol. 1995;8:854-858.
16.
Tellechea O., Reis JP, Domingues JC, Baptista APMonoclonal antibody Ber EP4 distinguishes basal-cell carcinoma from squamous-cell carcinoma of the skin. Am J Dermatopathol. 1993;15:452-455.
17.
Kato N., Endo Y., Tamura G., Motoyama T.Ameloblastoma with basal cell carcinoma-like feature emerging as a nasal polyp . Pathol Int. 1999;49:747-751.
18.
Vigneswaran N. , Whitaker SB, Budnick SD, Waldron CAExpression patterns of epithelial differentiation antigens and lectin-binding sites in ameloblastomas: a comparison with basal cell carcinomas. Hum Pathol. 1993;24:49-57.
19.
Matsuo A., Ueno S.Immunohistochemical demonstration of keratin in ameloblastoma as an indication of tumor differentiation. J Oral Maxillofac Surg. 1991;49: 282-288.
20.
Murphy GF, Flynn TC, Rice RH, Pinkus GSInvolucrin expression in normal and neoplastic human skin: a marker for keratinocyte differentiation. J Invest Dermatol. 1984;82:453-457.
21.
Altini M., Coleman H., Doglioni C., Favia G., Maiorano E.Calretinin expression in ameloblastomas. Histopathology. 2000;37:27-32.
22.
Kumamoto H. , Ohki K., Ooya K.Expression of p63 and p73 in ameloblastomas . J Oral Pathol Med. 2005;34: 220-226.
23.
Reis-Filho JS, Torio B., Albergaria A., Schmitt FCp63 expression in normal skin and usual cutaneous carcinomas. J Cutan Pathol. 2002;29:517-523.
24.
Park HR, Min SK, Cho HD, Kim KH, Shin HS, Park YEExpression profiles of p63, p53, survivin, and hTERT in skin tumors. J Cutan Pathol. 2004;31:544-549.
25.
Lawson BF, Griffin JW, Waldron CABasal-cell carcinoma of the gingiva. Report of a case. Oral Surg Oral Med Oral Pathol. 1967;24:648-653.
26.
Peters RA, Gingrass RP, Reyes CN, Hintz CSBasal cell carcinoma of the oral cavity: report of case. J Oral Surg. 1972;30:63-66.
27.
van der Wal KG, Mulder JW, Beetstra A.Basal-cell carcinoma of the vermilion border of the upper lip. A case report. Int J Oral Surg.1982;11:77-79.
28.
Williamson JJ, Cohney BC, Henderson BMBasal cell carcinoma of the mandibular gingiva . Arch Dermatol. 1967;95: 76-80.
29.
Liroff KP, Zeff S.Basal cell carcinoma of the palatal mucosa. J Oral Surg. 1972;30:730-733.
30.
Nauta JM, Panders AK, Schoots CJ, Vermey A., Roodenburg JLPeripheral ameloblastoma. A case report and review of the literature. Int J Oral Maxillofac Surg. 1992;21:40-44.
31.
Philipsen HP , Reichart PA, Nikai H., Takata T., Kudo Y.Peripheral ameloblastoma: biological profile based on 160 cases from the literature. Oral Oncol. 2001;37:17-27.
32.
Thissen MR, Neumann MH, Schouten LJA systematic review of treatment modalities for primary basal cell carcinomas . Arch Dermatol. 1999;135:1177-1183.
33.
Dixon AY, Lee SH, McGregor DHHistologic evolution of basal cell carcinoma recurrence. Am J Dermatopathol. 1991;13:241-247.
34.
Nagore E., Grau C., Molinero J., Fortea JMPositive margins in basal cell carcinoma: relationship to clinical features and recurrence risk. A retrospective study of 248 patients. J Eur Acad Dermatol Venereol. 2003;17:167-170.
35.
Walker P., Hill D.Surgical treatment of basal cell carcinomas using standard postoperative histological assessment. Australas J Dermatol. 2006;47:1-12.
