This study reports 3 unusual cases of malignant transformation in mature cystic teratoma of the ovary (dermoid cyst), namely carcinosarcoma, atypical choroid plexus papilloma, and papillary thyroid carcinoma, the last case involving both ovaries and with peritoneal dissemination. Adequate sampling is essential in such ovarian tumors to establish their teratomatous origin and avoid an erroneous diagnosis of primary ovarian or metastatic tumors. The authors present the clinicopathological findings in these 3 cases with a review of literature.
RussellPFarnsworthA, eds. Surgical Pathology of the Ovaries. Edinburgh, UK: Churchill Livingstone; 1997.
2.
RobboySJMutterGLPratJBentleyRRussellPAndersonMC eds. Robboy’s Pathology of the Female Reproductive Tract. 2nd ed.Edinburgh, UK: Churchill Livingstone Elsevier; 2008:754-759.
3.
HanadaMTsujimuraTShimizuH. Multiple malignancies (squamous cell carcinoma and sarcoma) arising in a dermoid cyst of the ovary. Acta Pathol Jpn. 1981;31:681-688.
4.
TyagiSPMaheshwariVTyagiNTewariK. Double malignancy in a benign cystic teratoma of the ovary (a case report). Indian J Cancer. 1993;30:140-142.
5.
AroraDSHaldaneS. Carcinosarcoma arising in a dermoid cyst of the ovary. J Clin Pathol. 1996;49:519-521.
6.
FadareOBossuytVMartelMParkashV. Primary osteosarcoma of the ovary: a case report and literature review. Int J Gynecol Pathol. 2007;26:21-25.
7.
CabibiDMartoranaACappelloFBarresiEDi GangiCRodolicoV. Carcinosarcoma of monoclonal origin arising in a dermoid cyst of ovary: a case report. BMC Cancer. 2006;6:47.
8.
WeiFJiangZYanC. Analysis of 20 mature ovarian cystic teratoma cases in postmenopausal women. Chin Med J (Engl). 2001;114:137-138.
9.
KefeliMKandemirBAkpolatIYildirimAKokcuA. Rhabdomyosarcoma arising in a mature cystic teratoma with contralateral serous carcinoma: case report and review of the literature. Int J Gynecol Pathol. 2009;28:372-375.
10.
FujiiHYoshidaMGongZX. Frequent genetic heterogeneity in the clonal evolution of gynecological carcinosarcoma and its influence on phenotypic diversity. Cancer Res. 2000;60:114-120.
11.
McCluggageWG. Uterine carcinosarcomas (malignant mixed Mullerian tumors) are metaplastic carcinomas. Int J Gynecol Cancer. 2002;12:687-690.
ManoMSRosaDDAzambujaE. Current management of ovarian carcinosarcoma. Int J Gynecol Cancer. 2007;17:316-324.
14.
HarrisMADelapLMSenguptaPS. Carcinosarcoma of the ovary. Br J Cancer. 2003;88:654-657.
15.
von GuntenMBurgerHVajtaiI. Choroid plexus papilloma developing in a dermoid cyst of ovary. Histopathology. 2006;49:204-205.
16.
HasselblattMBohmCTatenhorstL. Identification of novel diagnostic markers for choroid plexus tumors: a microarray-based approach. Am J Surg Pathol. 2006;30:66-74.
17.
JeibmannAHasselblattMGerssJ. Prognostic implications of atypical histologic features in choroid plexus papilloma. J Neuropathol Exp Neurol. 2006;65:1069-1073.
18.
RothLMMillerAW3rdTalermanA. Typical thyroid-type carcinoma arising in struma ovarii: a report of 4 cases and review of the literature. Int J Gynecol Pathol. 2008; 27:496-506.
19.
RothLMKarseladzeAI. Highly differentiated follicular carcinoma arising from struma ovarii: a report of 3 cases, a review of the literature, and a reassessment of so-called peritoneal strumosis. Int J Gynecol Pathol. 2008;27:213-222.
20.
GargKSoslowRARiveraMTuttleMRGhosseinRA. Histologically bland “extremely well differentiated” thyroid carcinomas arising in struma ovarii can recur and metastasize. Int J Gynecol Pathol. 2009;28:222-230.
21.
RobboySJShaco-LevyRPengRY. Malignant struma ovarii: an analysis of 88 cases, including 27 with extraovarian spread. Int J Gynecol Pathol. 2009;28:405-422.
22.
MakaniSKimWGabaAR. Struma ovarii with a focus of papillary thyroid cancer: a case report and review of the literature. Gynecol Oncol. 2004;94:835-839.